Phenylalanine conjugated supramolecular hydrogels developed from the mafenide and flurbiprofen multidrug for biological applications

Manna, Utsab; Roy, Rajdip; Dutta, Abhishek; Roy, Nabanita

doi:10.1039/d2ob02300h

Cited by 3 publications

(1 citation statement)

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“…Hence, it is quite understandable that designing of a suitable gelator/metallogelator a priori is really a challenging task due to the lack of any detailed molecular level information on the gelation mechanism. Basically by utilizing the merits of hydrogen bond-functionalized supramolecular synthon, many groups effectively demonstrated the gelation phenomena in the context of the crystal engineering approach − for the supramolecular gels, particularly because the solvent does not take part in gel network formation. Metallogels, on the other hand, are special types of gels where metal salt and coordinative ligands exist in an organized fashion to form gel.…”

Section: Introductionmentioning

confidence: 99%

Zn(II)-Coordination Complex(s) from Chiral Bisamides of L-Phenylalanine: Nanoscale-Based Biological Applications and Metallogelation

Manna,

Dutta,

Baskey

2023

Inorg. Chem.

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Three 3-pyridyl-containing small organic bisamide molecules attached with innocent L-phenylalanine (PHE) side chain as building blocks and positional isomeric toluoyl terminals (PME, MME, and OME) have rationally been designed and synthesized for developing a new series of Zn II -coordination complexes. One of the unique molecular frameworks, having two hydrogen bond-equipped monodentate metal-coordinating sites and biologically potent chiral PHE moiety, was combined with Zn II halide salts under various conditions to produce the coordination complexes (CC1−CC7), thoroughly characterized by the single-crystal X-ray diffraction (SXRD) technique. Maintaining the similar component ratios of acquired CCs in 1:1 DMSO−water produced low-molecular weight metallogels (LMWGs) of PME/MME as envisaged from a rheologyand crystal engineering-based structural rationale. A structure−property correlation from the basis of PXRD of the bulk and xerogels and SXRD data of the isolated single crystals of reaction products clearly supports the crystal engineering-based design strategy based on which the metallogels are prepared. Hand-ground nanoscale ZnCl 2 -based coordination complex CC1 of PME was also studied for cytotoxicity (HEK-293 cell line) and anticancer activities (B16-F10 cell line) in the MTT assay.

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Section: Introductionmentioning

confidence: 99%

Zn(II)-Coordination Complex(s) from Chiral Bisamides of L-Phenylalanine: Nanoscale-Based Biological Applications and Metallogelation

Manna,

Dutta,

Baskey

2023

Inorg. Chem.

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Natural Andrographolide Isolated from Andrographis paniculata as Potent Epileptic Agent: Spectroscopy, Molecular Structure, and Molecular Docking Investigation

et al. 2023

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NMR of soft matter systems

Wallace

2023

Nuclear Magnetic Resonance

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This chapter summarises recent advances and applications of solid-state, solution-state and gel-state NMR techniques to study soft matter systems. Original research articles published between March 2022 and March 2023 are discussed that cover liquid crystals, surfactants, gels, polymer solutions and other soft matter systems. Each section of the review focuses on a different NMR technique, including 1D and 2D solution-state experiments, 2H NMR, nuclear Overhauser effect (NOE) measurements, pulsed-field gradient (diffusion) NMR, relaxation measurements, experiments on quadrupolar counterions and solid-state NMR.

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Phenylalanine conjugated supramolecular hydrogels developed from the mafenide and flurbiprofen multidrug for biological applications

Abstract: A well-known nonsteroidal anti-inflammatory drug (NSAID), flurbiprofen (FLR), was firstly conjugated individually with two naturally occurring amino acids such as L-phenylalanine (PHE) and L-alanine (ALA). These covalent amidic bioconjugates were...

Cited by 3 publications

References 71 publications

Zn(II)-Coordination Complex(s) from Chiral Bisamides of L-Phenylalanine: Nanoscale-Based Biological Applications and Metallogelation

Zn(II)-Coordination Complex(s) from Chiral Bisamides of L-Phenylalanine: Nanoscale-Based Biological Applications and Metallogelation

Natural Andrographolide Isolated from Andrographis paniculata as Potent Epileptic Agent: Spectroscopy, Molecular Structure, and Molecular Docking Investigation

NMR of soft matter systems

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