Phenyl boronic acid -PEG-stearic acid biomaterial-based and sialic acid targeted nanomicelles for colon cancer treatment

Jangid, Ashok Kumar; Solanki, Raghu; Jadav, Mahima; Bora, Saumyadeep; Patel, Sunita; Pooja, Deep; Kulhari, Hitesh

doi:10.1016/j.colsurfa.2022.130445

Cited by 6 publications

(1 citation statement)

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“…Boronic acids and boronate materials have attracted wide research attention due to their biocompatibility, degradability, and sensitivity to external stimuli. − In particular, arylboronic acids exhibit a rich reactivity, which endows arylboronic acid–based materials with a broad diversity of applications. , Boronates are usually synthesized by constructing reversible dynamic chemical bonds between boronic acid and cis 1,2- or 1,3-dihydroxy compounds including diols, catechols, phosphates, salicylic acid, siloxanes, and basic diacids. − In addition, the boron atom in boronic acid or boronates has an empty p -orbital that provides Lewis acidity and capacity of coordination with electron donors such as F – , CN – , amino, hydroxyl, and carboxylic acid groups. − Benefiting from these properties, organic boronic acids and boronates containing functional groups can recognize or capture sugars, glycoproteins, glucosamines, amino acids, RNA, ATP, and germs. − …”

Section: Introductionmentioning

confidence: 99%

Enantiomer Recognition Based on Chirality Transfer from Chiral Amines to Ternary Dynamic Covalent Systems

Wang,

Gao,

Yan

et al. 2024

J. Org. Chem.

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Enantiomer recognition is usually required in organic synthesis and materials and life sciences. This paper describes an enantiomer recognition method based on ternary dynamic covalent systems constructed via the complexation of chiral amines with a chiral boronate derived from 1,4-phenylenediboric acid and an L-DOPAmodified naphthalenediimide. The ternary systems aggregate into chiral assemblies driven by π−π interactions, and the chirality is transferred from the chiral amines to assemblies with high stereospecificity. Consequently, the enantiomer composition of chiral amines and the absolute configuration of the major enantiomer can be determined according to the sign of the Cotton effect of the ternary system by using circular dichroism (CD) spectroscopy. This method offers the advantage of using the long wavelength CD signals of the boronate at around 520 nm, thereby avoiding interference with those of the carbon skeleton. This ternary system provides a novel approach to the design of enantiomer recognition systems.

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