Abstract:Voltage-dependent Ca( 2+ ) channels not only mediate the entry of Ca( 2+ ) ions into excitable cells but are also involved in a variety of Ca( 2+ )-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The alpha-1A isoform is abundantly expressed in neuronal tissue and corresponds to the P/Q Ca( 2+ ) channel type. The P/Q Ca( 2+ ) channel is responsible for presynaptic neurotransmitter release. Abnormalities in this channel could lead to abnormal neurotran… Show more
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