Phenoxodiol sensitizes metastatic colorectal cancer cells to 5-fluorouracil- and oxaliplatin-induced apoptosis through intrinsic pathway

Yaylaci, Esra; Onen, Hacer Ilke; Sağlam, Atiye Seda Yar

doi:10.17179/excli2020-2042

Cited by 2 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PHX, a semi-synthetic derivative of genistein and daidzein, was the second most potent compound tested and has previously been shown to displace E2 from ERα in rat uteri (EC 50 of ∼500nM). 55 PHX, also known as idroxinil and haginin E, has been studied for its ability to sensitize colon cancer cells to 5-fluorouracil and oxiplatin through induction of caspase-3 RNA levels and activity 70 though clinical use has not been successful due to low bioavailability. 71 However, the concentrations used in these studies generally were much higher (1-10μM) than the observed EC 50 we determined for ERα activation (<20nM), comparable to what we observed in the zebrafish model.…”

Section: Discussionmentioning

confidence: 99%

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

Bolt,

Oceguera,

Singh

et al. 2024

iScience

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

Bolt,

Oceguera,

Singh

et al. 2024

iScience

View full text Add to dashboard Cite

The role of isoflavones in augmenting the effects of radiotherapy

Ivashkevich

2023

Front. Oncol.

View full text Add to dashboard Cite

Cancer is one of the major health problems and the second cause of death worldwide behind heart disease. The traditional soy diet containing isoflavones, consumed by the Asian population in China and Japan has been identified as a protective factor from hormone-related cancers. Over the years the research focus has shifted from emphasizing the preventive effect of isoflavones from cancer initiation and promotion to their efficacy against established tumors along with chemo- and radiopotentiating effects. Studies performed in mouse models and results of clinical trials emphasize that genistein or a mixture of isoflavones, containing in traditional soy diet, could be utilized to both potentiate the response of cancer cells to radiotherapy and reduce radiation-induced toxicity in normal tissues. Currently ongoing clinical research explores a potential of another significant isoflavone, idronoxil, also known as phenoxodiol, as radiation enhancing agent. In the light of the recent clinical findings, this article reviews the accumulated evidence which support the clinically desirable interactions of soy isoflavones with radiation therapy resulting in improved tumor treatment. This review discusses important aspects of the development of isoflavones as anticancer agents, and mechanisms potentially relevant to their activity in combination with radiation therapy of cancer. It gives a critical overview of studies characterizing isoflavone targets such as topoisomerases, ENOX2/PMET, tyrosine kinases and ER receptor signaling, and cellular effects on the cell cycle, DNA damage, cell death, and immune responses.

show abstract

Phenoxodiol sensitizes metastatic colorectal cancer cells to 5-fluorouracil- and oxaliplatin-induced apoptosis through intrinsic pathway

Cited by 2 publications

References 44 publications

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

The role of isoflavones in augmenting the effects of radiotherapy

Contact Info

Product

Resources

About