Phenotypical characterization of tree nuts and peanut allergies in east Mediterranean children

Çetinkaya, Pınar Gür; Büyüktiryaki, Betül; Soyer, Özge; Şahiner, Ümit Murat; Saçkesen, Cansın

doi:10.1016/j.aller.2019.07.005

Cited by 23 publications

(20 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the consumption of tree nuts in Turkey usually begins during infancy. The high rate of allergy to tree nuts in Turkey is consistent with the country’s consumption patterns 18 . A study previously conducted in Turkey reported that the most frequent tree nut allergies were hazelnut, pistachio, and cashew, 19 which is consistent with the present study’s findings that pistachio was the most frequent trigger of FIA in the infant group and hazelnut was the most common trigger in the toddler and preschool children groups.…”

Section: Discussionsupporting

confidence: 92%

Food‐induced anaphylaxis in infants, as compared to toddlers and preschool children in Turkey

Kahveci

Akarsu

Koken

et al. 2020

Pediatric Allergy Immunology

Self Cite

View full text Add to dashboard Cite

Background: The literature includes scarce data on infants with food-induced anaphylaxis (FIA). Materials and Methods: Medical records of the patients diagnosed with FIA aged 0-6 years between 2015 and 2020 were retrospectively analyzed. Results: During the study period, there were 451 instances of FIA in 314 patients, of which 175 (38.8%) occurred in 160 infants (50.9%). The median (IQR) age of infants was 7 months (6-9 months) with a male predominance (67.5%), of which 7.5% had multiple instances (≥2) and 60% atopic dermatitis. The most common triggers were cow's milk (51.4%), tree nuts (16.6%), and hen's egg (15.4%), whereas tree nut was the most common trigger in toddlers (35.8%) and preschool children (35.2%). Skin and neurologic symptoms, and nausea-vomiting occurred more frequently (P = .003, P ≤ .001, and P = .003, respectively), whereas respiratory symptoms occurred less commonly in infants compared to toddlers and preschool children (P ≤ .001). In infants, 65 (37.1%) mild, 92 (52.6 %) moderate, and 18 (10.3%) severe episodes of anaphylaxis were detected. History of recurrent wheezing (OR: 6.837 [95% CI: 1.940-24.097], P = .003) and tree nut allergy (OR: 2.849 [95% CI: 1.056-7.688], P = .039) were found to be independent risk factors for moderate-to-severe anaphylactic reactions. 40.6% of the infants received adrenaline, which was lower than the toddlers (49.7%) and preschool children (57.6%) (P = .005). Conclusion: There is no doubt that food-induced anaphylaxis is a medical emergency, specifically in young children. Pediatricians should be aware of the distinct features of infant anaphylaxis, particularly gastrointestinal and neurologic symptoms to provide effective treatment as soon as possible. K E Y W O R D S Epinephrine, food-induced anaphylaxis, infants, preschool children, toddlers 1 | INTRODUC TI ON Currently, the incidence of anaphylaxis is increasing, particularly in children. 1 Anaphylaxis can be induced by a variety of agents, but the food is the most common etiology in children. Cow's milk, hen's egg, and peanut are the most common triggers, but any food can potentially provoke anaphylaxis, including tree nuts, soy and other legumes, fish, vegetables, fruits, and grains; 2,3 however, the frequency

show abstract

Section: Discussionsupporting

confidence: 92%

Food‐induced anaphylaxis in infants, as compared to toddlers and preschool children in Turkey

Kahveci

Akarsu

Koken

et al. 2020

Pediatric Allergy Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Turkey is one of the leading countries in the production and consumption of tree nuts like hazelnut, pistachio and walnut and they are used in many local cuisine recipes. The high rates of tree nuts allergy are consistent with the country's consumption patterns [10]. However, in Turkey, cashew is not cultivated and cashew consumption is low.…”

Section: Discussionsupporting

confidence: 64%

“…A previous study conducted in Turkey showed that the most frequent food allergens were egg, cow's milk, hazelnut, peanut, walnut, lentil, and wheat [9]. However, this study was criticized for inappropriate food allergen panel [10]. Our study showed that cow's milk, egg, hazelnut, sesame, walnut, cashew, pistachio, peanut, wheat and almond allergy were the top 10 food allergens among young children in Turkey.…”

Section: Discussionmentioning

confidence: 59%

Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0–2 Years

Kahveci

Koken

Şahiner

et al. 2020

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Objective: Precise diagnosis of allergy requires knowledge of the population's food allergy (FA) spectrum and predictors. Methods: Medical charts of Turkish children aged 0-2 years with FA and/or atopic dermatitis (AD) were reviewed. Results: A total of 1,389 patients, 912 with FA and 1,140 with AD, were included. In the FA group, the most frequently diagnosed FAs were egg white (75.9%), cow's milk (55.7%), tree nuts (31.5%) and sesame (20.6%). The detection of FA in 99% of children with any kind of FA necessitate testing with egg white, cow's milk, hazelnut, sesame, walnut, cashew, and pistachio. In the FA group, 72.7 and 56.8% had AD and multiple FA respectively. Multiple FA (56.8 vs. 49.8%) and hen's egg allergy (85.5 vs. 50.2%, p < 0.005) were more common and cow's milk allergy (51.4 vs. 67.1%, p < 0.005) less common in the AD subgroup of the FA group than in the non-AD subgroup. Multiple FA likelihood increases parallel to the severity of AD (p < 0.05). In the AD group, 58.2% had an immunoglobulin E-mediated FA. The risk of concomitant FA increased as the age at symptom onset of AD decreased (OR 0.800 [95% CI 0.731-0.875]; p < 0.001) and the severity of AD increased (OR 2.350 [95% CI 1.898-2.911]; p < 0.001). Conclusion: Although severe and early-onset AD is a predictor of the presence and magnitude of FA in infancy, the spectrum of FA is a reflection of cultural characteristics. The clinical presentations of both AD and FA may in fact be an expression of the extent of the immune dysregulation underlying atopy and allergy.

show abstract

“…In this respect, the sequence similarities observed between the homologous allergens of Anacardiaceae, e.g., between Pis v 1 and Ana o 3 or between Pis v 2 and Ana o 2, account for the high level of cross-reactivity and cross-allergenicity observed between pistachio and cashew. The IgE-binding cross-reactivity the major allergens from pistachio, Pis v 1, Pis v 2 and Pis v 3, share with homologous proteins from peanut, tree nuts and proteins from, sesame, buckwheat, peppercorn or mango, has a clinical incidence and in particular, helps to discriminate between allergies and co-sensitizations [19,22,[70][71][72][73][74][75][76][77][78]. Whereas co-sensitization frequently occurs between pistachio and cashew, it is clinically relevant in only one-third of cases [72].…”

Section: Discussionmentioning

confidence: 99%

IgE-Binding Epitopes of Pis v 1, Pis v 2 and Pis v 3, the Pistachio (Pistacia vera) Seed Allergens

et al. 2021

View full text Add to dashboard Cite

Sequential IgE-binding epitopes were identified on the molecular surface of the Pis v 1 (2S albumin), Pis v 2 (11S globulin/legumin) and Pis v 3 (7S globulin/vicilin)—major allergens from pistachio (Pistacia vera) seeds—using the Spot technique. They essentially consist of hydrophilic and electropositively charged residues well exposed on the surface of the allergens. Most of the epitopic regions identified on Pis v 1 and Pis v 3 do not coincide with the putative N-glycosylation sites and thus are not considered as glycotopes. Surface analysis of these epitopic regions indicates a high degree of conformational similarity with the previously identified epitopic regions of the corresponding allergens Ana o 1 (vicilin), Ana o 2 (legumin) and Ana o 3 (2S albumin) from the cashew (Anacardium occidentale) nut. These results offer a molecular basis for the IgE-binding cross-reactivity often observed between pistachio and cashew nut. They support the recommendation for prescribing pistachio avoidance in cashew allergic patients. Other conformational similarities were identified with the corresponding allergens Ses i 1 (2S albumin), Ses i 3 (vicilin) and Ses i 6 (legumin) from sesame (Sesamum indicum), and Jug r 1 (2S albumin), Jug r 2 (vicilin) and Jug r 4 (legumin) from walnut (Juglans regia). Conversely, conformation of most of the epitopic regions of the pistachio allergens often differs from that of epitopes occurring on the molecular surface of the corresponding Ara h 1 (vicilin), Ara h 2 (2S albumin) and Ara h 3 (legumin) allergens from peanut (Arachis hypogaea).

show abstract

Phenotypical characterization of tree nuts and peanut allergies in east Mediterranean children

Cited by 23 publications

References 36 publications

Food‐induced anaphylaxis in infants, as compared to toddlers and preschool children in Turkey

Food‐induced anaphylaxis in infants, as compared to toddlers and preschool children in Turkey

Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0–2 Years

IgE-Binding Epitopes of Pis v 1, Pis v 2 and Pis v 3, the Pistachio (Pistacia vera) Seed Allergens

Contact Info

Product

Resources

About