2019
DOI: 10.1007/s00249-019-01393-0
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Phenotypic, structural, and ultrastructural analysis of triple-negative breast cancer cell lines and breast cancer stem cell subpopulation

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Cited by 7 publications
(4 citation statements)
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“…Similar to biochemical heterogeneity observed within CSCs (Bocci, Gearhart-Serna et al 2019, Moreira, Brayner et al 2019), CSCs can be biophysically strikingly different too In a recent study, Chen et al, showed the association of biophysical properties of CSCs and their ability to invade, migrate, and initiate tumors, using the SUM149 inflammatory breast cancer (IBC) stem cells (Chen, Allen et al 2019). In this study, the authors sorted SUM149 CSCs based on the expression of aldehyde dehydrogenase enzyme (ALDH) and assayed biophysical properties of ALDH+ and ALDH-cells in terms of deformability, adhesion strength and contractility.…”
Section: Biophysical Characterization Of Cscs and Their Subsetsmentioning
confidence: 62%
“…Similar to biochemical heterogeneity observed within CSCs (Bocci, Gearhart-Serna et al 2019, Moreira, Brayner et al 2019), CSCs can be biophysically strikingly different too In a recent study, Chen et al, showed the association of biophysical properties of CSCs and their ability to invade, migrate, and initiate tumors, using the SUM149 inflammatory breast cancer (IBC) stem cells (Chen, Allen et al 2019). In this study, the authors sorted SUM149 CSCs based on the expression of aldehyde dehydrogenase enzyme (ALDH) and assayed biophysical properties of ALDH+ and ALDH-cells in terms of deformability, adhesion strength and contractility.…”
Section: Biophysical Characterization Of Cscs and Their Subsetsmentioning
confidence: 62%
“…The strongest evidence of this sponging effect comes from the first discovery of the binding of CDR1as to an miRNA that contains sequences matching 74 miR-7 seeds and is tightly bound by the AGO protein (miRNA-binding protein), which strongly inhibits the activity of miR-7 in nerve tissue and leads to an increase in the miR-7 targeting level, thus affecting the development of tumors ( 31 , 39 ). CircRNAs regulate miRNA expression in the cytoplasm by acting as miRNA sponges and absorbing miRNAs or other targets to regulate tumor metabolism ( 7 , 40 , 41 ). The adsorption of miRNA by circRNA results in the formation of the circRNA/miRNA/mRNA regulatory axis by reducing miRNA expression and releasing mRNA from functional inhibition ( 42 ) ( Figure 1A ).…”
Section: The Functions Of Circrnasmentioning
confidence: 99%
“…TNBC is responsible for 15%–20% of all breast cancers and remains the most challenging subtype of breast cancer. For a specific molecular target therapy in the prognosis of patients with TNBC, there is seldom clinically meaningful improvement; therefore, TNBC is one of the worst prognosis among breast cancer subtypes of all types due to the high propensity for progression, difficulty of identifying effective targets, and lack of specific targeted therapy, leading to a greater recurrence and metastasis potential and shorter overall survival ( 7 , 8 ). The heterogeneity of breast cancer causes great confusion in diagnosis and treatment and affects the survival rate, treatment response, and tumor growth rate ( 9 , 10 ).…”
Section: Introductionmentioning
confidence: 99%
“…Conventional chemotherapy preferentially targets proliferating cells which can leave behind resistant stem-like cells, which can cause recurrence [ 9 ]. Within the TNBC cell lines BT-549 and Hs 578T, there are three different subpopulations [ 10 ]: (1) the CD44 + CD24 − cells characterise the breast cancer stem mesenchymal-like phenotype (cancer stem cells, CSC), (2) the CD44 − CD24 + cells are associated with epithelial cells and are largely present in distant metastases [ 11 ], and (3) the CD44 + CD24 + cells with mesenchymal and epithelial features are plastic and able to self-renew [ 12 ]. Due to the different signalling pathways in epithelial and mesenchymal cancer stem populations, they respond differently to treatments.…”
Section: Introductionmentioning
confidence: 99%