Phenotypic expression, body mass index and insulin resistance in relation to LH levels in women with polycystic ovary syndrome

Antimullerian hormone levels are inversely associated with body mass index (BMI) in women with polycystic ovary syndrome

“…AMH and LH levels have been shown to be positively correlated [16]. It has been suggested that lower LH concentrations in obese women are a result of increased aromatization of androgens to estrogens in the peripheral fat tissue, resulting in LH suppression [17]. Other working theories suggest that obesity may affect the catabolism of AMH, that obesity could reduce the ovarian potential, or that obesity may be related to ovarian dysfunction [12].…”

Do the Anti-Müllerian Hormone Levels of Adolescents with Polycystic Ovary Syndrome, Those Who Are at Risk for Developing Polycystic Ovary Syndrome, and Those Who Exhibit Isolated Oligomenorrhea Differ from Those of Adolescents with Normal Menstrual Cycles?

“…The serum AMH level is also positively correlated with the serum androgen levels in PCOS patients [25]. It has been suggested that the lower LH levels evident in obese women are attributable to increased aromatization of androgens to estrogens in peripheral fat tissue, suppressing LH production [26]. Other working models suggest that obesity may affect AMH catabolism, reduce the ovarian potential, or trigger ovarian dysfunction [27].…”

Proinflammatory cytokines and polycystic ovary syndrome

“…На сегодня СПКЯ нередко диагностируется не только у пациенток с ожирением, но и у женщин с нормальной массой тела [2]. Так, в популяционных исследованиях, прове-денных I. Katsikis, а также А. Balen, показа-но, что от 30 до 70% женщин с СПКЯ имеют нормальную массу тела [3,4]. И если многие механизмы формирования СПКЯ у пациен-ток с избыточной массой тела на сегодня раскрыты, то патогенез синдрома у женщин с нормальной массой тела до сих пор окон-чательно не выяснен.…”