Phenotypic Detection of Extended-Spectrum Beta Lactamases (Esbls) Producing Organisms Among Enterobacteriaceae and Their Antibiotic Resistance Pattern in Urinary Tract Infection (Uti) at Kumaun Region, Uttarakhand

Abstract

BACKGROUND Urinary tract infection (UTI) is one of the major health problems affecting all age groups. Extended Spectrum β-Lactamases (ESBLs) producing Enterobacteriaceae exhibits a resistant mechanism, which challenges the strategies of broad-spectrum antibiotics used in treatment of UTI, thus limiting therapeutic options. Knowing resistance pattern of such multidrug resistant pathogens will help in the appropriate usage of antimicrobial agents. The study was carried out to determine the prevalence of ESBL among the Enterobacteriaceae uropathogens and their antimicrobial resistance pattern. MATERIALS AND METHODS All the uropathogenic isolates obtained from symptomatic UTI cases were identified by conventional methods. The prevalence of potential ESBL producers among Enterobacteriaceae isolates was explored. Antimicrobial susceptibility testing was done by Kirby-Bauer disc diffusion method and the results were interpreted according to Clinical Laboratory Standards Institute 2014 guidelines. Study Design-Descriptive study.