Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge

Groot, Linsey E. S. de; Brinkman, Paul; Piñeros, Yanaika S. Sabogal; Priller, Josef; Hamann, Jörg; Böttcher, Chotima; Lutter, René

doi:10.1002/eji.202149222

Cited by 1 publication

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References 9 publications

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“…Immunomodulatory therapies target AMs that exist in multiple potential sites during a viral infection of the respiratory tract. In the case of rhinovirus infection, AMs can be M1/M2 polarized by GM-CSF/M-CSF or IFN-γ/IL-4 stimulation ( 86 , 87 ). M1/M2 herein can be likewise classified by their functions and origins rather than dichotomy.…”

Section: Prospect Of Ams As Target For the Treatment Of Ahr-related V...mentioning

confidence: 99%

Alveolar macrophages and airway hyperresponsiveness associated with respiratory syncytial virus infection

et al. 2022

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Respiratory syncytial virus (RSV) is a ubiquitous pathogen of viral bronchiolitis and pneumonia in children younger than 2 years of age, which is closely associated with recurrent wheezing and airway hyperresponsiveness (AHR). Alveolar macrophages (AMs) located on the surface of the alveoli cavity are the important innate immune barrier in the respiratory tract. AMs are recognized as recruited airspace macrophages (RecAMs) and resident airspace macrophages (RAMs) based on their origins and roaming traits. AMs are polarized in the case of RSV infection, forming two macrophage phenotypes termed as M1-like and M2-like macrophages. Both M1 macrophages and M2 macrophages are involved in the modulation of inflammatory responses, among which M1 macrophages are capable of pro-inflammatory responses and M2 macrophages are capable of anti-proinflammatory responses and repair damaged tissues in the acute and convalescent phases of RSV infection. Polarized AMs affect disease progression through the alteration of immune cell surface phenotypes as well as participate in the regulation of T lymphocyte differentiation and the type of inflammatory response, which are closely associated with long-term AHR. In recent years, some progress have been made in the regulatory mechanism of AM polarization caused by RSV infection, which participates in acute respiratory inflammatory response and mediating AHR in infants. Here we summarized the role of RSV-infection-mediated AM polarization associated with AHR in infants.

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Section: Prospect Of Ams As Target For the Treatment Of Ahr-related V...mentioning

confidence: 99%

Alveolar macrophages and airway hyperresponsiveness associated with respiratory syncytial virus infection

et al. 2022

View full text Add to dashboard Cite

show abstract

Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge

Cited by 1 publication

References 9 publications

Alveolar macrophages and airway hyperresponsiveness associated with respiratory syncytial virus infection

Alveolar macrophages and airway hyperresponsiveness associated with respiratory syncytial virus infection

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