Phenotypic Characteristics Associated With Reduced Short Physical Performance Battery Score in COPD

Vastus Lateralis Fiber Shift Is an Independent Predictor of Mortality in Chronic Obstructive Pulmonary Disease

“…Given the known relationship between exercise capacity and survival (9), these data are consistent with our prior studies, which demonstrated a relationship between fiber shift (although not fiber atrophy) and impaired exercise capacity (3) and functional performance (10). Nevertheless, it remains unclear whether fiber shift causes poor exercise tolerance or is a manifestation of exercise intolerance and reduced physical activity, which are both associated with increased mortality in COPD (9,11).…”

Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years

“…Our study failed to replicate the earlier findings of BERNABEU-MORA et al [6] and our previous study [8] of a correlation between SPPB scores and quadriceps strength, and we also observed no correlation between change in RF CSA and individual components of the SPPB. Several reasons could explain this, including the small sample size and the fact that our cohort was highly functioning at baseline (SPPB>10), giving a limited spread of SPPB values.…”

“…Consistent with this, change in SPPB was principally driven by the chair-stand element, which we have previously shown to be related to quadriceps strength [10]. Given the known predictive power of the SPPB for functional decline, hospitalisation and mortality [8], our data suggest that skeletal muscle dysfunction is an appropriate target for intervention in COPD, and that SPPB can be a useful endpoint in clinical trials assessing impact on skeletal muscle dysfunction. …”

Role of the Timed Up and Go Test in Patients With Chronic Obstructive Pulmonary Disease

“…Therefore, more pragmatic performance field tests such as the Timed Up and Go (TUG) and the Short Physical Performance Battery (SPPB) (and its component parts) need to be considered, not as replacements, but as potential objective tools to stratify patients in the community to identify those with functional impairment. [6][7][8][9][10] Both the TUG test and the SPPB are clinical assessment tools used to assess mobility. The SPPB comprises a composite score of balance, ability to stand, and gait speed and is related to functional exercise capacity and lower limb muscle function.…”