Phenotypic characteristics according to insulin sensitivity in non-obese Korean women with polycystic ovary syndrome

Park, Hwi Ra; Choi, Youngju; Lee, Hyejin; Oh, Jee-Young; Hong, Young Sun; Sung, Yeon Ah

doi:10.1016/j.diabres.2007.01.063

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…Because the evaluation of hirsutism was relatively subjective (Wild et al, 2005) and the natural cut-off value of mF -G score was not distinct (DeUgarte et al, 2006); however, we used the highest score in other studies as an upper normal limit (Hatch et al, 1981). Using the Rotterdam criteria, the present study shows that BMI in women with PCOS in Korea was lower than in studies of Caucasian women with PCOS (Belosi et al, 2006;Welt et al, 2006;Barber et al, 2007) and that it was similar to other studies of Asian patients with PCOS (Chen et al, 2006;Park et al, 2007). Women in the IM/PCO group had a similar waist circumference to controls, whereas women in the IM/ HA/PCO and IM/HA groups had a greater waist circumference than those in the IM/PCO and control groups.…”

Section: Discussionsupporting

confidence: 79%

Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Kim

Chae

Choi

et al. 2008

Fertility and Sterility

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MATERIALS AND METHODS: Charts from 251 women with PCOS defined by ovulatory dysfunction and hyperandrogenism were reviewed. Sixty-six charts that included liver enzymes determinations were selected for further analysis. All patients had been examined by a single physician (RK). Age, BMI, modified Ferriman-Gallwey (F-G) scores, and endocrine and metabolic data were extracted. Thirteen patients were deemed to have NAFLD based on (1) elevations of AST, ALT, or both, (2) negative hepatitis serology, (3) absence of significant alcohol intake (% 1 drink/week), and (4) abdominal ultrasound demonstrating findings characteristic of NALFD in the absence of biliary tract disease. Fifty-one women with PCOS and normal liver enzymes had sufficient data for comparison. Subjects underwent a 3-hour 100g glucose tolerance test with insulin levels. Area under the curve for insulin was calculated using the trapezoidal rule. Statistical analysis was performed using Student's t-test (with logarithmic transformation when necessary). Significance was determined when p < 0.05. RESULTS: Women with PCOS and NAFLD were significantly more obese, more insulin resistant, and demonstrated higher glycemic levels than those without NAFLD.Mean SHBG concentrations were lower in the NAFLD group. All other physical, metabolic, and endocrine parameters (including androgens, lipids, and gonadotropins) were similar.CONCLUSIONS: NAFLD is common in women with PCOS. Extreme obesity and insulin resistance are the principal risk factors predicting this condition in women with PCOS. Because progression to non-alcoholic steatohepatitis (a risk factor for cirrhosis) is reversible with lifestyle modifications and insulin sensitizers, it may be prudent to assess liver enzymes in all women with PCOS.

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Section: Discussionsupporting

confidence: 79%

Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Kim

Chae

Choi

et al. 2008

Fertility and Sterility

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“…However, the prevalence of glucose intolerance in our patients was much lower when compared with their white counterparts (12,25,26). It was also much lower compared with other Asian countries (e.g., in South Asia, China, and Korea), but their studies were comparatively few in number, with small numbers of subjects (10,31), or immigrants in Western countries were involved in the studies (12,29,32).…”

Section: Discussionmentioning

confidence: 55%

Prevalence of insulin resistance and determination of risk factors for glucose intolerance in polycystic ovary syndrome: a cross-sectional study of Chinese infertility patients

Wei

Young

Kuo

et al. 2009

Fertility and Sterility

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“…This difference was still significant after adjustment for age, central obesity and free testosterone. The concept that insulin resistance is a more powerful predictor for glucose intolerance than obesity in Korean women with PCOS also is supported by a recent, separate study in which Korean women with PCOS were significantly more insulin resistant than age-and BMImatched control groups [22].…”

Section: Discussionmentioning

confidence: 93%

The prevalence and risk factors for glucose intolerance in young Korean women with polycystic ovary syndrome

Lee

Sung

et al. 2009

Endocr

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Insulin resistance and hyperinsulinemia play important roles in the pathogenesis of polycystic ovary syndrome (PCOS). In addition, some women with PCOS have been shown to have insulin secretory defects and can be predicted to be at an increased risk for glucose intolerance. We performed the present study to determine the prevalence and risk factors for glucose intolerance in Korean women with PCOS. We consecutively recruited 194 women with PCOS diagnosed by American Society for Reproductive Medicine/European Society of Human Reproduction and Embryology (ASRM/ESHRE) criteria. Anthropometric measures, 75 g oral glucose tolerance test (OGTT), and measurement of insulin sensitivity (insulin mediated glucose uptake; IMGU) using euglycemic hyperinsulinemic clamp technique were performed. In women with PCOS, the prevalence of impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG) was 17.0% and type 2 diabetes 1.0%, and in lean women with PCOS, the prevalence of IGT and/or IFG was 5.9%. The prevalence of glucose intolerance was 28-fold higher in women with PCOS, and 9.8-fold higher in lean women with PCOS compared to age-matched Korean women. Women with glucose intolerance had higher BMI, waist circumference, free testosterone, fasting insulin, 2-h post-load insulin, total cholesterol, LDL cholesterol, triglyceride and lower sex hormone binding globulin and IMGU than women with normal glucose tolerance (NGT) (P < 0.05). IMGU was the most powerful predictor for glucose intolerance after adjustment for age, BMI, waist circumference, and hyperandrogenemia. The 2-h OGTT was the best screening measure for glucose intolerance and diagnosis of diabetes in women with PCOS. Young Korean women with PCOS have high prevalence for glucose intolerance and type 2 diabetes, and insulin resistance is the most important factor associated with glucose intolerance.

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Phenotypic characteristics according to insulin sensitivity in non-obese Korean women with polycystic ovary syndrome

Cited by 14 publications

References 19 publications

Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

Prevalence of insulin resistance and determination of risk factors for glucose intolerance in polycystic ovary syndrome: a cross-sectional study of Chinese infertility patients

The prevalence and risk factors for glucose intolerance in young Korean women with polycystic ovary syndrome

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