Phenotypic changes in low-density lipoprotein particles as markers of adverse clinical outcomes in COVID-19

Carmo, Helison Rafael Pereira do; Yoshinaga, Marcos Y.; Castillo, Alejandro Rosell; Chaves‐Filho, Adriano B.; Bonilha, Isabella; Oliveira, Joaquim; Muraro, Stéfanie Primon; Souza, Gabriela Fabiano de; Davanzo, Gustavo Gastão; Perroud, Maurício W.; Lukhna, Kishal; Ntsekhe, Mpiko; Davidson, Sean M; Velloso, Lı́cio A.; Nadruz, Wilson; Carvalho, Luiz Sérgio F.; Sáinz‐Jaspeado, Miguel; Farias, Alessandro S.; Proença-Módena, José Luiz; Moraes-Vieira, Pedro M.; Karathanasis, Sotirios K.; Yellon, Derek M.; Miyamoto, Sayuri; Remaley, Alan T.; Spósito, Andrei C.

doi:10.1016/j.ymgme.2023.107552

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Its activity leads to the release of several proinflammatory agents that contribute to endothelial damage and atherosclerosis [30]. The majority of published studies indicate that patients infected with SARS-CoV-2, especially those with a severe course of the disease, express an increased concentration of Lp-PLA2 [31][32][33]. Lp-PLA2 has also been considered to be a prognostic marker for the course of COVID-19 [10].…”

Section: Discussionmentioning

confidence: 99%

Organ-Dysfunction Markers in Mild-to-Moderate COVID-19 Convalescents

Wiśniewska,

Kijak,

Nowak

et al. 2024

JCM

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Background: A coronavirus disease 2019 (COVID-19) outbreak led to a worldwide pandemic. COVID-19 not only caused acute symptoms during the severe phase of the disease, but also induced long-term side effects on the functioning of many organs and systems. Symptoms that were associated with the disease and present at least 3 months after recovery were named long COVID. The aim of this study was to assess if mild-to-moderate COVID-19 may lead to the dysfunction of respiratory, cardiovascular, neural, and renal systems in healthy blood donors who recovered from the disease at least 6 months earlier. Methods: Here, we examined 294 adults among volunteer blood donors divided into convalescents (n = 215) and healthy controls (n = 79). Concentrations of soluble CD163, TGF beta, Lp-PLA2, NCAM-1, S100, NGAL, and creatinine were measured either by ELISA or automated methods. The probability value p < 0.05 was considered as statistically significant. Results: We found significant differences in Lp-PLA2, S100, and NCAM-1 between convalescents and never-infected subjects. Lp-PLA2 and NCAM-1 were lower, and S100 higher, in convalescents than in the control group. Conclusion: Mild-to-moderate COVID-19 convalescents are at a low risk of developing lung fibrosis or chronic kidney disease. However, they should regularly carry out their prophylaxis examinations for early detection of possible negative outcomes of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Organ-Dysfunction Markers in Mild-to-Moderate COVID-19 Convalescents

Wiśniewska,

Kijak,

Nowak

et al. 2024

JCM

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“…Remnant cholesterol (RC) is an emerging tool representing cholesterol in triglyceride-rich lipoproteins and is implicated in a spectrum of conditions, encompassing cardiovascular and metabolic disorders [ 9 ]. Serum lipids have emerged as potential biomarkers for various diseases, including cardiovascular and cerebrovascular diseases [ 10 , 11 ], metabolic diseases [ 12 ], infectious diseases [ 13 ], hematological diseases [ 14 ], and cancer [ 15 ]. Most previous studies on cholesterol metabolism focused on low-density lipoprotein cholesterol (LDL-C) and HDL-C. RC was recently demonstrated to equally precisely predict atherosclerotic cardiovascular disease (CVD) risk compared to LDL-C or very low-density lipoprotein (VLDL) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study

Yan,

La,

Jiang

et al. 2024

Lipids Health Dis

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Objectives While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates lipid metabolism, and rheumatoid arthritis (RA) has not been investigated. Accordingly, this study evaluated whether RC is associated with RA disease events. Methods Data were collected and specifically extracted from the National Health and Nutrition Examination Survey (NHANES) 1999–2008 database. The RC value was derived by subtracting the combined amount of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) from the total cholesterol (TC). The association between RC and RA was evaluated using multivariate regression analysis and subgroup analysis. Results The study analyzed 7777 patients, of which 581 patients (7.47%) were diagnosed with RA. After accounting for different covariates, the multivariate logistic regression analysis revealed a notable correlation between increased RC levels and an increased likelihood of RA (odds ratio OR = 1.54; 95% confidence interval CI: 1.11–2.13; P = 0.0092). The interaction test did not yield statistically significant effects on this association. The linear correlation between RC and RA was observed within restricted cubic spline regression model limitations. Conclusion The results suggest that higher RC levels are associated with increased odds of RA, indicating that RC can serve as a novel and convenient index for forecasting the likelihood of RA in the United States. Additionally, these findings offer insights into early intervention strategies for susceptible populations at risk of developing RA.

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High-Density Lipoproteins at the Interface between the NLRP3 Inflammasome and Myocardial Infarction

Carmo,

Bonilha,

Barreto

et al. 2024

IJMS

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Despite significant therapeutic advancements, morbidity and mortality following myocardial infarction (MI) remain unacceptably high. This clinical challenge is primarily attributed to two significant factors: delayed reperfusion and the myocardial injury resulting from coronary reperfusion. Following reperfusion, there is a rapid intracellular pH shift, disruption of ionic balance, heightened oxidative stress, increased activity of proteolytic enzymes, initiation of inflammatory responses, and activation of several cell death pathways, encompassing apoptosis, necroptosis, and pyroptosis. The inflammatory cell death or pyroptosis encompasses the activation of the intracellular multiprotein complex known as the NLRP3 inflammasome. High-density lipoproteins (HDL) are endogenous particles whose components can either promote or mitigate the activation of the NLRP3 inflammasome. In this comprehensive review, we explore the role of inflammasome activation in the context of MI and provide a detailed analysis of how HDL can modulate this process.

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Phenotypic changes in low-density lipoprotein particles as markers of adverse clinical outcomes in COVID-19

Cited by 4 publications

References 42 publications

Organ-Dysfunction Markers in Mild-to-Moderate COVID-19 Convalescents

Organ-Dysfunction Markers in Mild-to-Moderate COVID-19 Convalescents

The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study

High-Density Lipoproteins at the Interface between the NLRP3 Inflammasome and Myocardial Infarction

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