1988
DOI: 10.1038/bjc.1988.297
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Phenotypic and genotypic heterogeneity of peripheral T-cell lymphoma

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Cited by 28 publications
(12 citation statements)
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“…Although some cases with large cell morphology are composed of an almost pure proliferation of tumor cells, most PTCL-NOS-in contrast to B-cell lymphomas-comprise a heterogeneous cellular population [16,22,42]. Apart from the tumor cells, there were abundant histiocytes, eosinophils, plasma cells, B-lymphocytes, and reactive T-lymphocytes.…”
Section: Lineage Of Ptclmentioning
confidence: 97%
See 1 more Smart Citation
“…Although some cases with large cell morphology are composed of an almost pure proliferation of tumor cells, most PTCL-NOS-in contrast to B-cell lymphomas-comprise a heterogeneous cellular population [16,22,42]. Apart from the tumor cells, there were abundant histiocytes, eosinophils, plasma cells, B-lymphocytes, and reactive T-lymphocytes.…”
Section: Lineage Of Ptclmentioning
confidence: 97%
“…This heterogeneity might result from technical problems because, in addition to the neoplastic cells, PTCL also comprises varying numbers of reactive T-lymphocytes [16,22,27,42]. Since most of these studies were performed, methods have become available to assess the morphology in immunostained slides and to double stain cells on paraffin sections.…”
Section: Introductionmentioning
confidence: 98%
“…In previous studies, we found it difficult to reliably distinguish neoplastic T-cells from reactive bystander T-cells in PTCL [15,42], because cytologic atypia may be subtle and cannot be readily identified in immunostained slides. As reactive T-cells may be abundant in PTCL [43][44][45], they may impede the definition of the tumour cell phenotype. This might be one reason for the great variation in published phenotypes for AILT [7,12,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] and PTCL-NOS [7][8][9][10][11][12][13][14].…”
Section: Inflammatory Background In Nodal Ptclmentioning
confidence: 99%
“…For Southern blot analysis, high molecular weight DNA was extracted from the biopsies by routine methods, digested with 3/4 restriction enzymes, Southern blotted, and probed with 32 P-labeled TCR and Ig probes as previously described. 20 …”
Section: Genotypic Studiesmentioning
confidence: 99%