Phenotypic and functional studies of leukocytes in human endometrium and endometriosis

Jones, Rebecca; Bulmer, Judith N.; Searle, Roger F.

doi:10.1093/humupd/4.5.702

Cited by 97 publications

(52 citation statements)

References 43 publications

(46 reference statements)

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“…Dual immuofluorescence analysis further identified endothelial cells and inflammatory cells, such as macrophages and T-lymphocytes, as cells markedly expressing IL-1RI in the stroma. These findings are suggestive of a relationship between IL-1RI expression and the implant's activity considering that active endometriotic lesions show a more marked vascularization and leukocyte infiltration (Halme et al 1987, Hill et al 1988, Wiegerinck et al 1993, Kokorine et al 1997, Jones et al 1998, McLaren 2000, Witz 2002, Taylor & Mueller 2004. …”

Section: Discussionmentioning

confidence: 93%

“…Inflammation around and within active endometrial implants, and increased leukocyte infiltration and cytokine secretion as compared to eutopic endometrial tissue have widely been described (Halme et al 1987, Hill et al 1988, Tseng et al 1996, Jolicoeur et al 1998, Jones et al 1998, Witz 2002, Wu & Ho 2003. The secretion of proinflammatory and mitogenic proteins by endometriotic lesions and associated immune cells into the peritoneal environment may contribute to a cascade of events favoring tissue remodeling and invasion of the host tissue, angiogenesis and cell proliferation in the growing lesions and further chemoattraction of leukocytes to these foci of peritoneal inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

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The establishment and progression of ectopic endometrial implants are dependent upon their interaction with and responsiveness to the stimuli present in their new environment. According to our and other previous studies, immune cells-derived cytokines, such as IL-1, may alone or in concert with estrogens, enhance the capability of ectopic endometrial cells to implant and develop into the host tissue. In the present study, immunohistochemical and dual immunofluorescence analyses showed that the functional signaling interleukin-1 receptor type 1 (IL-1RI) is expressed in endometriotic tissue, particularly in the glands, and identified endothelial cells, macrophages, and T-lymphocytes as cells having marked expression of IL-1RI. The highest concentrations of IL-1RI protein in endometriotic tissue, as evaluated using histological score (HSCORE) and measured by ELISA, were found in red endometriotic lesions as compared with typical black-blue or white lesions. Western blotting showed a significant increase in the levels of the 50 kDa band, whose apparent molecular weight corresponds to the soluble form of IL-1RI. RT-PCR analysis of IL-1 mRNA levels showed a pattern of expression comparable to that of the protein. Interestingly, IL-1RI expression was more significant in the proliferative than in the secretory phase of the menstrual cycle. Marked expression of IL-1RI, the functional signaling receptor that mediates cell activation by IL-1, in red endometriotic implants, which are highly vascularized and represent the earliest and most active forms of the disease, point to a higher cell receptivity for IL-1 in these lesions, a relationship with the activity of the disease and a possible involvement in the early steps of endometriotic tissue growth and development. Reproduction (2007) 133 265-274

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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“…Endometriosis has also characteristics of both a chronic inflammatory disease and a wound healing process: in endometriotic tissue (i) elevated levels of macrophages [52], T lymphocytes [79], and mast cells [80,81], and a reduced numbers of granulocytes [79] have been described, (ii) there is evidence of active ECM remodeling and synthesis [82,83], and (iii) fibromuscular differentiation [84,85], and (iv) elevated levels of cyclooxygenase-2 (COX-2) have been reported [86,87]. The elevated COX-2 levels in endometriotic lesions can be the result of the local inflammatory environment, however, may also be due to the elevated levels of locally produced estrogen.…”

Section: Ectopic Endometrium Creates a Pro-angiogenic Microenvironmentmentioning

confidence: 99%

Vascular development in endometriosis

et al. 2005

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Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests that angiogenesis is required for the development and persistence of endometriosis. In this review the state-of-the-art with regard to our understanding of the role of angiogenesis in the ectopic implantation and survival of menstrual endometrial tissue will be discussed.

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“…Lymphocytes are normally present is small percentages within the endometrium and fallopian tubes and increase in number during endometriosis [7] and salpingitis [8]. Similarly, the number of lymphocytes in the endocervix increases during sexually transmitted infection with Neisseria gonorrhoeae or C. trachomatis [9].…”

mentioning

confidence: 99%

Chlamydia trachomatisInfection Induces Mucosal Addressin Cell Adhesion Molecule–1 and Vascular Cell Adhesion Molecule–1, Providing an Immunologic Link between the Fallopian Tube and Other Mucosal Tissues

et al. 2001

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The development of a protective vaccine against the sexually transmitted disease caused by Chlamydia trachomatis may prevent complications associated with insidious infection. Vaccination via the vaginal route may not be practical, and other routes should be investigated. To this end, the adhesion molecules induced on the fallopian tube endothelium during infection with C. trachomatis were characterized. Adhesion molecules were identified in fallopian tube biopsy specimens cultured with 5 x 10(6) infection-forming units of C. trachomatis serovar E. Frozen sections were prepared from these tissues and were stained by immunohistochemical techniques. Infection with live, but not UV-inactivated, C. trachomatis induced a significant increase in levels of vascular cell adhesion molecule-1 and the mucosal addressin cell adhesion molecule-1 but not of other adhesion molecules. Therefore, infection with C. trachomatis induces adhesion molecules that are associated with other mucosal tissues and inflammatory sites, which suggests that mucosal routes of immunization may be effective.

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Phenotypic and functional studies of leukocytes in human endometrium and endometriosis

Cited by 97 publications

References 43 publications

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Vascular development in endometriosis

Chlamydia trachomatisInfection Induces Mucosal Addressin Cell Adhesion Molecule–1 and Vascular Cell Adhesion Molecule–1, Providing an Immunologic Link between the Fallopian Tube and Other Mucosal Tissues

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