Phenotypic and functional heterogeneity of porcine blood monocytes and its relation with maturation

Chamorro, Sonia; Revilla, Concepción; Álvarez, Belén; Alonso, Fernando; Ezquerra, Ángel; Domı́nguez, Javier

doi:10.1111/j.1365-2567.2004.01994.x

Cited by 72 publications

(65 citation statements)

References 54 publications

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“…CD14 lo , CD163 hi monocytes also expressed the highest levels of the swine leukocyte Ag (SLA) class II genes (SLA-DRB1, SLA-DQA, SLA-DQB1, SLA-DRA, SLA-DRB1, SLA-DRB2), suggesting a role in Ag processing and presentation (42). A similar role in MHC processing has been described for human ' (42, 43).…”

Section: Discussionmentioning

confidence: 74%

Comparative Analysis of Monocyte Subsets in the Pig

Fairbairn

Kapétanovic

Beraldi

et al. 2013

The Journal of Immunology

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Human and mouse monocyte can be divided into two different subpopulations based on surface marker expression: CD14/16 and Ly6C/CX3CR1, respectively. Monocyte subpopulations in the pig were identified based on reciprocal expression of CD14 and the scavenger receptor CD163. The two populations, CD14hi-CD163low and CD14low-CD163hi, show approximately equal abundance in the steady-state. Culture of pig PBMCs in CSF1 indicates that the two populations are a maturation series controlled by this growth factor. Gene expression in pig monocyte subpopulations was profiled using the newly developed and annotated pig whole genome snowball microarray. Previous studies have suggested a functional equivalence between human and mouse subsets, but certain genes such as CD36, CLEC4E, or TREM-1 showed human-specific expression. The same genes were expressed selectively in pig monocyte subsets. However, the profiles suggest that the pig CD14low-CD163high cells are actually equivalent to intermediate human monocytes, and there is no CD14− CD16+ “nonclassical” population. The results are discussed in terms of the relevance of the pig as a model for understanding human monocyte function.

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Section: Discussionmentioning

confidence: 74%

Comparative Analysis of Monocyte Subsets in the Pig

Fairbairn

Kapétanovic

Beraldi

et al. 2013

The Journal of Immunology

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“…+ monocytes produce more TNF-, express high levels of adhesion molecules and are better at presenting antigens to T cells when compared to CD163 − monocytes [48]. In addition, the DC derived from CD163 + monocytes, express higher levels of MHC class II and CD80/86 and are more efficient antigen presenting cells [49].…”

Section: Cd163mentioning

confidence: 99%

Membrane markers of the immune cells in swine: an update

Piriou-Guzylack¹,

2008

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-Besides their breeding value, swine are increasingly used as biomedical models. As reported in three international swine clusters of differentiation (CD) workshops and in the animal homologue section of the last workshop for the determination of human leukocyte differentiation antigens (HLDA 8), characterisation of leukocyte surface antigens by monoclonal antibodies and other molecular studies have determined the cell lineages and blood leukocyte subsets implicated in the immune response, including cell adhesion molecules involved in cell trafficking. This review focusses on the current state of knowledge of porcine leukocyte differentiation and major histocompatibility complex (SLA) molecules. Examples of porcine particularities such as the double-positive T lymphocytes with the phenotype CD4 + CD8 low and CD4 − CD8 low T cell subsets and the persistence of SLA class II after T-lymphocyte activation are illustrated, as well as the shared characteristics of the Artiodactyla group, such as the high proportion of TcR (T cell receptor) T cells in blood and other lymphoid tissues. Furthermore, discrepancies between swine and humans, such as CD16 expression on dendritic cells and CD11b (wCD11R1) tissue distribution are outlined. The rapidly growing information should facilitate manipulation of the swine immune system towards improving disease control, and open new avenues for biomedical research using the pig as a model. cluster of differentiation (CD) / monoclonal antibody / immune system / histocompatibility system / pig

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“…CD163 is highly expressed in these mature tissue macrophages, whereas its expression level is modest in monocytes (65). This is important because it distinguishes CD163 as a differentiation marker of the macrophage lineage with increased expression along the macrophage differentiation pathway (65,66). Studies have demonstrated CD163-expressing macrophages in a number of diseases associated with inflammation, including arthritic joints (67), tumors (68) and atherosclerosis (69).…”

Section: Cd163: the Second Definite Receptormentioning

confidence: 99%

The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors

Liu

Lin

Xiang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. At present, it is commonly accepted that atherosclerosis is a chronic inflammatory disease characterized by disorder of the arterial wall. As one of the inflammatory cytokines of the tumor necrosis factor superfamily, tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in the formation and progression of atherosclerosis. TWEAK, when binding to its initial receptor, fibroblast growth factor inducible molecule 14 (Fn14), exerts adverse biological functions in atherosclerosis, including dysfunction of endothelial cells, phenotypic change of smooth muscle cells and inflammatory responses of monocytes/macrophages. However, accumulating data supports that, besides Fn14, TWEAK also binds to cluster of differentiation (CD)163, an anti-inflammatory cytokine and a scavenger receptor exclusively expressed by monocytes and macrophages. Furthermore, it has been demonstrated that CD163 is able to internalize TWEAK and likely elicits protective effects in atherosclerosis by terminating inflammation induced by TWEAK. In the present study, the role of TWEAK in atherosclerosis was reviewed, with a predominant focus on CD163 and Fn14 receptors.

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Phenotypic and functional heterogeneity of porcine blood monocytes and its relation with maturation

Cited by 72 publications

References 54 publications

Comparative Analysis of Monocyte Subsets in the Pig

Comparative Analysis of Monocyte Subsets in the Pig

Membrane markers of the immune cells in swine: an update

The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors

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