Phenotypic Analysis and Characterization of CD34+ Cells from Normal Human Bone Marrow, Cord Blood, Peripheral Blood, and Mobilized Peripheral Blood from Patients Undergoing Autologous Stem Cell Transplantation

Pluripotent and myeloid-committed CD34+ subsets in hematopoietic stem cell allografts

“…However, a few studies on comparison of CD34 þ subsets from different cell sources have been published. 11,19,25 In line with those studies, pluripotent CD34 þ subsets were detected at significantly higher frequencies in the CD34 þ compartment of CB compared to that of BM and LPs. À subsets compared to adult stem cell sources.…”

The GOD of Hematopoietic Stem Cells: A Clonal Diversity Model of the Stem Cell Compartment

“…However, changes in the HSC compartment can be induced-for example through diseases, chemotherapy, transplantation, cytokine treatment, and aging. 43,34,[44][45][46][47][48][49][50][51][52][53] After such events the HSC compartment can become pauciclonal.…”

Umbilical Cord Blood Transplantation: A New Alternative Option

“…The poor correlation between CD34 content of infused UCB grafts and time to hematopoietic engraftment may be confounded by quantification of CD34 in UCB grafts pre-freezing versus post thaw and by reduced surface epitope density of CD34 on UCB progenitor cells. 22 In vitro analyses of UCB CD34 progenitors point to a less mature phenotype compared to adult marrow and peripheral blood grafts. 23 The frequency of early HSC is similar in adult marrow, mobilized peripheral blood, and UCB, but the proliferative potential of UCB is significantly higher.…”