Phenotype Profiling and Allergy in Otitis-Prone Children

Torretta, Sara; Carioli, Daniela; Ibba, Tullio; Folino, Francesco; Rosazza, Chiara; Fattizzo, Miriam; Marchisio, Paola

doi:10.3389/fped.2018.00383

Cited by 14 publications

(21 citation statements)

References 41 publications

(43 reference statements)

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“…Most relevant clinical articles 38,39,39,40,40,41,41,42,42,44‐47 included in the qualitative analyses, investigating specifically association between OME and allergy, are summarized in Table 3. The majority of articles included are of good quality and support a link between OME and allergy.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, Torretta et al 44 demonstrated that allergy or atopy was significantly higher in otitis‐prone children with OME than in those with simple RAOM: Atopy was found in 73% of the children with both RAOM and OME versus 39.5% of those with simple RAOM, while allergy was found in 60% and 36%, respectively. The authors 44 suggested that children with both RAOM and OME are clinically different from children with simple RAOM, as they have a more complex clinical presentation that may be sustained by underlying allergy or atopy. Interestingly, in the same manuscript, children with both RAOM and OME were more frequently affected by adenoid hypertrophy (AH) ( P = 0.016).…”

Section: Resultsmentioning

confidence: 99%

“…42 Furthermore, studies have documented that AR patients have a higher risk of ET dysfunction, particularly during childhood, than non-allergic ones. 12,43 Therefore, AR seems to be a common risk factor in children with Most relevant clinical articles 38,39,39,40,40,41,41,42,42,[44][45][46][47] included in the qualitative analyses, investigating specifically association between OME and allergy, are summarized in Table 3. The majority of articles included are of good quality and support a link between OME and allergy.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

“…Recently, Torretta et al44 demonstrated that allergy or atopy was significantly higher in otitis-prone children with OME than in those with simple RAOM: Atopy was found in 73% of the children with both RAOM and OME versus 39.5% of those with simple RAOM, while allergy was found in 60% and 36%, respectively. The authors44 Accordingly, some authors demonstrated that adenoid tissue and middle ear mucosa share the same inflammatory pattern in allergic children affected by OME 38. …”

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confidence: 99%

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Otitis media in children: Which phenotypes are most linked to allergy? A systematic review

Corso

Cantone²,

Galli

et al. 2021

Pediatric Allergy Immunology

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Background: Allergic rhinitis is a common childhood disease responsible for a major impact on quality of life and healthcare resources. Many hypotheses have been proposed to explain the link between allergy and otitis media, although a definitive mechanism has not been identified yet. One of the major critical points is that authors failed in distinguishing among different phenotypes of middle ear inflammation. This review pointed out literature evidence from the laboratory and clinical experience linking allergy to different phenotypes of otitis media in children. Methods: We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process. Our search yielded 3010 articles that were finally screened. This resulted in 20 manuscripts of which the full texts were included in a qualitative analysis. We paid particular attention in distinguishing among phenotypes of otitis media. Results: Clinical evidence and analyses of biomarkers suggested that allergy may be linked to some phenotypes of otitis media and, in particular, to otitis media with effusion (OME) and acute re-exacerbations in children with middle ear effusion. It was not possible to perform the analysis for allergy and acute and chronic otitis media because of paucity and heterogeneity of data. Conclusion: Allergy should be considered in the diagnostic workup of children with OME as well as OME should be excluded in children with persistent moderate to severe AR. In these cases, clinicians should evaluate prompt and accurate treatment of allergy in improving outcomes, although futures studies are required to increase evidence supporting that anti-allergy treatment may be effective in the recovery and outcome of otitis media with effusion.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

mentioning

confidence: 99%

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Otitis media in children: Which phenotypes are most linked to allergy? A systematic review

Corso

Cantone²,

Galli

et al. 2021

Pediatric Allergy Immunology

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“…A recent study [10] revealed higher prevalence of atopy or allergy in children with a recurrent presence of episodes of OME between acute infections (atopy: 73.0% vs. 39.5%, p < 0.001; allergy: 60.0% vs. 36.1%, p = 0.049), which may suggest that children with recurrent acute otitis media (AOM) with OME are clinically different from children with simple recurrent AOM, because they have a more complex clinical presentation that includes not only adenoidal disease and audiological impairment, but also an underlying allergy or atopy.…”

Section: The Role Of Allergy In Otitis Media With Effusionmentioning

confidence: 98%

Factors influencing the development of otitis media with effusion in children

Pazdro-Zastawny¹,

Zatoński²,

Orendorz-Frączkowska³

et al. 2019

polp

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Otitis media with effusion (OME) is one of the most frequent childhood diseases and the most common cause of hearing loss in childhood. Eighty per cent of all children have an episode of OME by the age of 10 years, typically by the age of three years. The disease is characterised by an accumulation of fluid in the middle ear behind an intact tympanic membrane in the absence of signs and symptoms of acute infection. This causes progressive conductive hearing loss, which is the main symptom of the disease. When left untreated, OME may lead to the development of adhesive otitis media, tympanic membrane abnormalities, tympanic sclerosis, cholesterol granuloma, or acquired primary cholesteatoma. The aetiology of OME is multifactorial. Allergy is considered an important aetiological mechanism of OME. An association between allergy, proinflammatory and immunoregulatory cytokines, obesity, a high-fat diet, and OME is discussed in this paper.

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International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Wise

Damask

Roland

et al. 2023

Int Forum Allergy Rhinol

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Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence‐based findings and recommendation from the full document. Methods ICAR‐Allergic Rhinitis 2023 employed established evidence‐based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results ICAR‐Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion The ICAR‐Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

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Phenotype Profiling and Allergy in Otitis-Prone Children

Cited by 14 publications

References 41 publications

Otitis media in children: Which phenotypes are most linked to allergy? A systematic review

Otitis media in children: Which phenotypes are most linked to allergy? A systematic review

Factors influencing the development of otitis media with effusion in children

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

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