Phénotype HLA et syndrome auto-immun multiple

Klisnick, A; Schmidt, Julia; Dupond, J.L.; Bouchou, K; Rousset, H.; Thieblot, P.; Vidal, É.; Aumaître, O.

doi:10.1016/s0248-8663(97)80910-1

Cited by 2 publications

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“…Type 3 MAS groups autoimmune thyroid disease, myasthenia gravis, thrombocytopenic purpura, and type 1 diabetes mellitus together with autoimmune skin disorders like Sjögren's syndrome, vitiligo, systemic lupus erythematosus, and dermatitis herpetiformis (1,4). In a retrospective analysis of 11 patients with type 3 MAS, Klisnick et al (5) found that 63.6% of the patients had segmental or bilateral vitiligo, and 90% presented with autoimmune thyroid disease. The authors concluded that the female sex and acrofacial topography of vitiligo, similar to those in our patient, could be used to predict associated autoimmune disorders in patients with vitiligo (5).…”

Section: Discussionmentioning

confidence: 99%

“…In a retrospective analysis of 11 patients with type 3 MAS, Klisnick et al (5) found that 63.6% of the patients had segmental or bilateral vitiligo, and 90% presented with autoimmune thyroid disease. The authors concluded that the female sex and acrofacial topography of vitiligo, similar to those in our patient, could be used to predict associated autoimmune disorders in patients with vitiligo (5). Vitiligo is a chronic autoimmune disease of the skin, characterized by acquired cutaneous depigmentation.…”

Section: Discussionmentioning

confidence: 99%

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Probable Multiple Autoimmune Syndrome in a Patient with Vitiligo, Autoimmune Thyroiditis, and Diabetes Mellitus: A Case Report

2020

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Introduction: Multiple autoimmune syndrome (MAS) is a rare syndrome in which the patient is diagnosed with three or more autoimmune diseases. Autoimmune skin disorders, such as vitiligo, alopecia areata, lupus erythematosus, Sjögren's syndrome, or dermatitis herpetiformis, often take part in MAS. The etiology of the syndrome is still unknown, but immunological, hormonal, genetic, and environmental factors possibly play a role. Case Presentation: A 63-year-old woman was admitted to our department with a rare combination of several autoimmune diseases, including vitiligo, autoimmune thyroiditis, and recently diagnosed diabetes mellitus. Although the immediate cause of her hospitalization was erysipelas of the left leg, type 3 MAS was suspected, based on the simultaneous presence of three autoimmune diseases. Type 3 MAS groups together conditions such as autoimmune thyroid disease, myasthenia gravis, thymoma, Sjögren's syndrome, pernicious anemia, idiopathic thrombocytopenic purpura, Addison's disease, type 1 diabetes mellitus, vitiligo, autoimmune hemolytic anemia, systemic lupus erythematosus, and dermatitis herpetiformis. The only criterion that needed to be fulfilled in our case, to establish the diagnosis of type 3 MAS, was a specific subtype of diabetes, namely, late-onset autoimmune diabetes (LADA). Conclusions: We presented a patient with possible type 3 MAS. Further investigations are needed for the diagnosis of LADA by a more precise serological examination of anti-IA and anti-GAD 65 antibodies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Probable Multiple Autoimmune Syndrome in a Patient with Vitiligo, Autoimmune Thyroiditis, and Diabetes Mellitus: A Case Report

2020

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Multiple Autoimmune Syndrome: A Study of 25 Senegalese Cases

Niasse¹,

Kane²,

Mabom³

et al. 2020

OJRA

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Introduction: Multiple autoimmune syndrome is rarely described in the African literature. We report 25 cases. Patients and Method: A Retrospective, descriptive study was carried out in the Rheumatology Department of Aristide Le Dantec University Hospital in Dakar from 2013 to September 2019. Patients with at least 3 distinct autoimmune diseases were included. Results: Twenty-five cases of multiple autoimmune syndrome were collected in 23 women and 2 men, with a mean age of 42.4 years (extremes: 24 and 67 years). The mode of discovery of the disease was a connective tissue disease in 19 cases (76%) and an organ-specific autoimmune disease in 6 cases. According to Humbert and Dupond's classification, 18 patients (72%) had both type 2 and type 3 criteria. An isolated type 2 was noted in 5 cases (20%) and an isolated type 3 in 1 case (4%). One case (4%) was unclassifiable. The evolution under treatment was marked by remission in 84% of cases. Conclusion: Multiple autoimmune syndromes account for 5.66% of the autoimmune diseases in our study. They predominate in young women with a mean age of 42.4 years. Not all entities were classifiable by the Humbert and Dupond's classification. The evolution under treatment was marked by remission in 84% of cases.

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Phénotype HLA et syndrome auto-immun multiple

Cited by 2 publications

References 0 publications

Probable Multiple Autoimmune Syndrome in a Patient with Vitiligo, Autoimmune Thyroiditis, and Diabetes Mellitus: A Case Report

Probable Multiple Autoimmune Syndrome in a Patient with Vitiligo, Autoimmune Thyroiditis, and Diabetes Mellitus: A Case Report

Multiple Autoimmune Syndrome: A Study of 25 Senegalese Cases

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