Phenotype frequencies of blood group systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran) in blood donors of south Gujarat, India

Abstract

Background:This is the first study on phenotype frequencies of various blood group systems in blood donors of south Gujarat, India using conventional tube technique.Material and Methods:A total of 115 “O” blood group donors from three different blood banks of south Gujarat were typed for D, C, c, E, e, K, Jka, Lea, Leb, P1, M, and N antigens using monoclonal antisera and k, Kpa, Kpb, Fya,Fyb, Jkb, S,s, Lua, and Lub antigens were typed using polyclonal antisera employing Indirect Antiglobulin Test. Antigens and phenotype frequencies were expressed as percentages.Results:From the 115 blood donor samples used for extended antigen typing in the Rh system, e antigen was found in 100% donors, followed by D [84.35%], C [81.74%], c [56.32%], and E [21.74%] with DCe/DCe (R1 R1, 40.87%) as the most common phenotype. k was found to be positive in 100% of donors and no K+k- phenotype was found in Kell system. For Kidd and Duffy blood group system, Jk(a+b+) and Fy(a-b-) were the most common phenotypes with frequency of 52.17% and 48.69%, respectively. In the MNS system, 39.13% donors were typed as M+N+, 37.39% as M+N-, and 23.48% as M-N+. S+s+ was found in 24.35% of donors, S+s- in 8.69%, and S-s+ as the commonest amongst donors with 66.96%. No Lu(a+b+) or Lu(a+b-) phenotypes were detected in 115 donors typed for Lutheran antigens. A rare Lu(a-b-) phenotype was found in 2.61% donors.Conclusion:Data base for antigen frequency of various blood group systems in local donors help provide antigen negative compatible blood units to patients with multiple antibodies in order to formulate in-house red cells for antibody detection and identification and for preparing donor registry for rare blood groups.

<p>Phenotype Frequencies of Major Blood Group Systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran) Among Blood Donors in the Eastern Region of Saudi Arabia</p>

“…10 The antigen frequencies of major blood group systems have been widely reported in the Caucasian, African, Indian, and Chinese populations. [11][12][13][14] However, information on antigen frequencies in Saudi Arabia has been limited to the ABO and Rh blood group systems. [3][4][5]7 To the best of our knowledge, this is the first study to report the extended antigen phenotyping of the major blood group systems in Saudi Arabia, specifically in the Eastern region.…”

Phenotypic Profile of Rh and Kell Blood Group Systems among Blood Donors in Cote d’Ivoire, West Africa

“…The frequencies of c and e antigens in our study are high (99, 85%) ( Table 1 ) while the frequencies of C and E antigens are lower, respectively, 21.97% and 13.82%. Among whites, European, and Asian people, e antigen is the most popular, and then comes C antigen [ 17 ]. As regards to C and E antigens, frequencies are higher than in our study (C 70% and E 26%) [ 5 , 9 , 12 , 17 ].…”

“…Among whites, European, and Asian people, e antigen is the most popular, and then comes C antigen [ 17 ]. As regards to C and E antigens, frequencies are higher than in our study (C 70% and E 26%) [ 5 , 9 , 12 , 17 ]. Among RhD negative donors, E antigen is absent.…”

ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India

“…The CCDEE phenotype was rare but more frequently observed (n = 4, table 2) than was predicted by our calculations of the CDE haplotype (n = 0, table 3); the 4 donors were unrelated based on the donors' residence, name, religion, location, and date of blood donation (data not shown). The prevalence of Kell antigens varied markedly among Indian populations: Thakral et al [4] reported for Northern India a K prevalence of 5.68%, which almost resembles the European situation, for instance 7.82% in Germany [11]; in West Bengal the K prevalence was 0.79% (table 1), more typical for most non-Caucasian populations [5].…”

“…The common antigens of the Rhesus and Kell blood group systems are also frequently tested in blood donors and patients because of their clinical relevance. Several studies from the 1960s addressed ABO and Rh antigens in various West Bengal populations [1], and several current studies [2][3][4][5][6], conducted in other parts of India, documented the antigen prevalence for the 3 blood group systems. The available data using current technology is limited for the Bengali population in eastern India [7,8] although approximately 91 million people live in the state of West Bengal, bordering Bangladesh to the west and north.…”