Phenotype characterization of non-cystic fibrosis bronchiectasis in India

Dhar, Raja; Chandrashekariah, Sagar; Rajagopalan, S.; Singh, Virendra; Swarnakar, Rajesh; Kant, Surya; Talwar, Deepak; Bhatnagar, Archana; Jindal, Aditya; Ghewade, Babaji; Gayathri, Devi H.J.; Nair, Girija; Modesti, Pietro Amedeo; Gami, Samir; Meshram, Sushant; Dutt, Naveen; Kaushik, Sushmita; Salvi, Sundeep; Limaye, Sneha; Aliberti, Stefano; Chalmers, James

doi:10.1183/1393003.congress-2017.pa4058

Cited by 7 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there have been limited data to support this view; thus, our study provided informative data about the prevalence of bronchiectasis in Korea. The reasons for the different prevalences among Asian and Western populations have been suggested to be a higher prevalence of pulmonary infection and pulmonary tuberculosis in Asians (28)(29)(30), which is supported by a high prevalence of the previous history of tuberculosis in this study. However, to elucidate the reasons for the higher prevalence of bronchiectasis in the Asian population, further studies evaluating the etiologies of bronchiectasis in various Asian countries are needed.…”

Section: Discussionsupporting

confidence: 76%

The disease burden of bronchiectasis in comparison with chronic obstructive pulmonary disease: a national database study in Korea

et al. 2019

View full text Add to dashboard Cite

Background: The prevalence and disease burden of bronchiectasis in comparison to those of chronic obstructive pulmonary disease (COPD) have not been well elucidated using a nationally representative database.Methods: We compared respiratory symptoms, physical activity, quality of life, and socioeconomic status in subjects with bronchiectasis versus those with COPD or control subjects participating in the Korea National Health and Nutrition Examination Survey 2007-2009. Participants were classified as physician-diagnosed bronchiectasis, COPD, and control (those without COPD or bronchiectasis). Results:The prevalence of bronchiectasis in subjects aged 40 years or older was 0.8%. Compared to COPD subjects, bronchiectasis subjects were more likely to be younger (mean 59.0 years, P<0.001), female (47.6%, P<0.001), and never-smoker (50.1%, P<0.001) and have had history of pulmonary tuberculosis (40.5%, P<0.001) and osteoporosis (19.1%, P=0.025). However, as in COPD subjects, bronchiectasis subjects had low family income (P<0.001) and the proportion of subjects working as manager/professional/office workers (6.4%, P<0.001) was smaller than that of control subjects. After adjusting for covariables, compared to control, bronchiectasis subjects but not COPD subjects were more likely to have respiratory symptoms [adjusted odds ratio (OR) =7.96, 95% confidence interval (CI): 2.10-30.12], limitation in physical activity (adjusted OR =9.43, 95% CI: 1.06-83.79), and low family income (adjusted OR =3.61, 95% CI: 1.75-7.47). Conclusions:The prevalence of bronchiectasis in subjects at least 40 years of age was 0.8% in Korea.Despite large number of young patients and low prevalence of smoking history, respiratory symptoms, limitation in physical activity, and low family income were significant burden in bronchiectasis subjects. Yang et al. The disease burden of bronchiectasis in comparison with COPD

show abstract

Section: Discussionsupporting

confidence: 76%

The disease burden of bronchiectasis in comparison with chronic obstructive pulmonary disease: a national database study in Korea

et al. 2019

View full text Add to dashboard Cite

show abstract

“…A recent pan-Indian study (n = 680) identified postinfection (41%) to be the primary cause for bronchiectasis with post-tuberculous disease identified as the predominant aetiology (29.8%), whilst ABPA is the most common cause after this and identified in 12% of Indian cases [56]. An aetiological study across different ethnicities in the Guangzhou region of mainland China (n = 148) identified idiopathic bronchiectasis (45%) as the most common cause with the high rates of disease related to post-infection (27%) also noted [57].…”

Section: Bronchiectasis In the Asia-pacific Regionmentioning

confidence: 99%

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

et al. 2018

View full text Add to dashboard Cite

Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Most focus to date has been on the study of airway bacteria, both as colonisers and causes of exacerbations. Modern molecular technologies including next generation sequencing (NGS) have become invaluable tools to identify microorganisms directly from sputum and which are difficult to culture using traditional agar based methods. These have provided important insight into our understanding of emerging pathogens in the airways of people with bronchiectasis and the geographical differences that occur. The contribution of the lung microbiome, its ethnic variation, and subsequent roles in disease progression and response to therapy across geographic regions warrant further investigation. This review summarises the known geographical differences in the aetiology, epidemiology and microbiology of bronchiectasis. Further, we highlight the opportunities offered by emerging molecular technologies such as -omics to further dissect out important ethnic differences in the prognosis and management of bronchiectasis.

show abstract

“…The first results were presented at the American Thoracic Society Conference in 2017, with 680 patients reported. In contrast to European cohorts, the majority of patients were male (60%) and post-tuberculosis was the most frequent underlying cause (35.7%) [ 50 ].…”

Section: Achievements Of Embarcmentioning

confidence: 99%

The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC): experiences from a successful ERS Clinical Research Collaboration

Chalmers

Crichton

Goeminne

et al. 2017

Breathe

Self Cite

View full text Add to dashboard Cite

In contrast to airway diseases like chronic obstructive pulmonary disease or asthma, and rare diseases such as cystic fibrosis, there has been little research and few clinical trials in bronchiectasis. Guidelines are primarily based on expert opinion and treatment is challenging because of the heterogeneous nature of the disease.In an effort to address decades of underinvestment in bronchiectasis research, education and clinical care, the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) was established in 2012 as a collaborative pan-European network to bring together bronchiectasis researchers. The European Respiratory Society officially funded EMBARC in 2013 as a Clinical Research Collaboration, providing support and infrastructure to allow the project to grow.EMBARC has now established an international bronchiectasis registry that is active in more than 30 countries both within and outside Europe. Beyond the registry, the network participates in designing and facilitating clinical trials, has set international research priorities, promotes education and has participated in producing the first international bronchiectasis guidelines. This manuscript article the development, structure and achievements of EMBARC from 2012 to 2017.Educational aimsTo understand the role of Clinical Research Collaborations as the major way in which the European Respiratory Society can stimulate clinical research in different disease areasTo understand some of the key features of successful disease registriesTo review key epidemiological, clinical and translational studies of bronchiectasis contributed by the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) project in the past 5 yearsTo understand the key research priorities identified by EMBARC for the next 5 years

show abstract

Phenotype characterization of non-cystic fibrosis bronchiectasis in India

Cited by 7 publications

References 0 publications

The disease burden of bronchiectasis in comparison with chronic obstructive pulmonary disease: a national database study in Korea

The disease burden of bronchiectasis in comparison with chronic obstructive pulmonary disease: a national database study in Korea

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC): experiences from a successful ERS Clinical Research Collaboration

Contact Info

Product

Resources

About