2009
DOI: 10.1038/onc.2009.436
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Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras–MKK3–p38 to regulate in vitro cellular invasion

Abstract: The Ras oncogene is known to activate three major MAPK pathways, ERK, JNK, p38 and exert distinct cellular phenotypes, that is, apoptosis and invasion through the Ras-MKK3-p38-signaling cascade. We attempted to identify the molecular targets of this pathway that selectively govern the invasive phenotype. Stable transfection of NIH3T3 fibroblasts with MKK3 act cDNA construct revealed similar p38-dependent in vitro characteristics observed in Ha-Ras EJ -transformed NIH3T3 cells, including enhanced invasiveness a… Show more

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Cited by 35 publications
(23 citation statements)
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“…5A, left panel). The MAPK kinase 3 (MKK3) is known to activate p38 MAPK␣ and stimulates mRNA expression of the p38 MAPK-responsive forkhead box M1 (FOXM1) gene in 3T3-L1 cells (43). SB202190, but not PD098058, efficiently abolished the MKK3 constitutively active form (CA)-induced FOXM1 mRNA expression, suggesting that SB202190 suppressed kinase activity of the p38 MAPK␣ in these cells.…”
Section: P38 Mapk Mediates the Effect Of Ampk On Gr-induced Transcripmentioning
confidence: 99%
“…5A, left panel). The MAPK kinase 3 (MKK3) is known to activate p38 MAPK␣ and stimulates mRNA expression of the p38 MAPK-responsive forkhead box M1 (FOXM1) gene in 3T3-L1 cells (43). SB202190, but not PD098058, efficiently abolished the MKK3 constitutively active form (CA)-induced FOXM1 mRNA expression, suggesting that SB202190 suppressed kinase activity of the p38 MAPK␣ in these cells.…”
Section: P38 Mapk Mediates the Effect Of Ampk On Gr-induced Transcripmentioning
confidence: 99%
“…It regulates different cellular functions. For example, it can inhibit proliferation (6 -8) and adhesion (9) and promote differentiation (7,10), apoptosis (11)(12)(13), migration (14), and invasion (15)(16). In addition, it can also activate proliferation (17)(18) or survival (19 -21).…”
mentioning
confidence: 99%
“…The MAP2K3 gene is translated into a mitogen-activated protein kinase 3 and is involved in the signal transduction that controls proliferation and programmed cell death 88. MAP2K3 protein is involved in the Ras-MKK3-p38-signaling cascade, the components of which may confer an invasive phenotype to the cell 89. Our study shows that the MAP2K3 gene is overexpressed in GCTB compared to normal tissue.…”
Section: Discussionmentioning
confidence: 65%