Phenotype and Outcomes of Phakic Versus Pseudophakic Primary Rhegmatogenous Retinal Detachments: Cataract or Cataract Surgery Related?

Ferrara, Mariantonia; Mehta, Alexander; Qureshi, Hamza; Avery, Peter; Yorston, David; Laidlaw, D A H; Williamson, Tom H.; Casswell, A G; Morris, Andrew H.; Jalil, Assad; Babar, Atiq R.; Goldsmith, Craig; Steel, David; Sanchez-Chicharro, Diego; Hughes, Edward; Herbert, E N; Jenkins, Huw; Khan, Imran; Ellis, John; Smith, Jonathan; Balaggan, Kamaljit S.; Cornish, Kurt Spiteri; Wakeley, Laura; Costen, M T J; Tarafdar, Sonali; Charles, Stephen; Winder, Stephen; Cochrane, Timothy; Ivanova, Tsveta; Papastavrou, Vasileios T.; Tanner, Vaughan

doi:10.1016/j.ajo.2020.09.036

Cited by 15 publications

(22 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found a mean age of 58.5 years at the time of cataract surgery preceding pseudophakic RRD in males, whereas the mean age at surgery is 74 years in the Norwegian population as a whole (Kristianslund et al 2021). These findings support evidence that males are younger at the time of lens exchange surgery as well as when presenting with RRD compared with females (Bjerrum et al 2013;Ferrara et al 2021). In addition, males experienced a shorter duration from surgery to RRD, indicating a stronger association between lens exchange surgery and RRD in males compared with females (Sheu et al 2010).…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Substantial increase in the incidence of rhegmatogenous retinal detachment in Western Norway over 20 years

Achour

Thomseth

Kvaløy

et al. 2022

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose: To investigate the incidence of rhegmatogenous retinal detachment (RRD) and describe characteristics of the RRD population. Methods: Retrospective, observational case series. Data on residents of South Rogaland, Norway, diagnosed with primary RRD in the period 2000-2019 were obtained by medical chart review. Patient demographics and prior intraocular surgery were documented. Incidence rates adjusted to the Norwegian population were calculated for 5-year periods and stratified by age, sex and lens status. Results: The RRD incidence increased from 12.6 per 100 000 person-years in 2000-2004 to 20.2 in 2015-2019. The RRD incidence increased by 2.9% per year (p < 0.0001) corresponding to an accumulated increase of 77%. Demographic changes accounted for 30% of the increase. The pseudophakic RRD incidence increased yearly by 4.9% (p < 0.0001), over double the rate of the phakic RRD increase of 2.3% (p = 0.0005). In individuals ≥50 years old, the annual RRD incidence increase was 4.5% (p = 0.019) for pseudophakic females, 3.9% (p = 0.001) for pseudophakic males and 2.6% (p = 0.03) for phakic females. Males were younger compared with females when undergoing lens exchange surgery, 58.5 (SD 12.5) versus 62.4 (SD 13.2) years, (p = 0.013) and when diagnosed with pseudophakic RRD, 61.9 (SD 12.5) versus 68.2 (SD 12.9) years, (p < 0.0001). There was no significant increase in subjects under 50 years of age. Conclusion:The RRD incidence increased dramatically over 20 years, of which 30% was attributed to demographic changes. The most pronounced change occurred in pseudophakic RRD, which calls for raised awareness of the individual risk related to lens exchange surgery.

show abstract

Section: Discussionsupporting

confidence: 82%

“…2013; Ferrara et al. 2021). In addition, males experienced a shorter duration from surgery to RRD, indicating a stronger association between lens exchange surgery and RRD in males compared with females (Sheu et al.…”

Section: Discussionmentioning

confidence: 99%

Substantial increase in the incidence of rhegmatogenous retinal detachment in Western Norway over 20 years

Achour

Thomseth

Kvaløy

et al. 2022

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…However, the total number of RRDs has increased by over 250, which suggests that larger numbers of cataract operations does not fully explain the increase in RRD incidence. A recent retrospective database review by the British and Eire Association of Vitreoretinal Surgeons (BEAVRS) reported that pseudophakic RRD has a significantly higher male predominance compared to phakic RRDs, which also supports the role of pseudophakia in increasing RRDs [ 23 ]. Van Leeuwen also observed an increase in both phakic and pseudophakic RRDs suggesting that increased cataract surgery alone could not account for the rise in RRD [ 5 ].…”

Section: Discussionmentioning

confidence: 97%

The Scottish RD survey 10 years on: the increasing incidence of retinal detachments

El-Abiary

Shams

Goudie

et al. 2022

Eye

Self Cite

View full text Add to dashboard Cite

Background The Scottish RD Survey reported an incidence of 12.05/100,000/yr in 2009. Data published from Denmark recently confirmed a 50% increase in RD presentations over the last 16 years. We set out to repeat the Scottish RD survey to determine if a similar trend has been observed in Scotland. Methods All 16 Scottish VR surgeons, who make up the collaboration of Scottish VR Surgeons (SCVRs) were asked to prospectively record all primary RDs presenting from 12th August 2019 to 11th August 2020. For consistency, the case definitions were the same as for the 2009 Scottish RD Survey. Basic demographic and clinical features were recorded. Age specific incidence was calculated from mid-year population estimates for 2019 obtained from the National Records of Scotland. Results There were 875 RRDs recorded, which gives an updated incidence of 16.02/100,000/year in Scotland. 62.8% occurred in males and the greatest increases were seen in males aged 50–59 (p = 0.0094), 60–69 (p = 0.0395) and females aged 40–49 (p = 0.0312) and 50–59 (p = 0.0024). The proportion of pseudophakic RRDs in this study is 29.4% (253/860). Compared to the 21.6% in the 2010 study, this represents a 28% increase (χ2 = 11.03, p = 0.0009). The proportion of macula-off RRDs remained generally stable at 58%. Conclusion Our study confirms that RRD is becoming more common in the UK, reflecting almost identical findings from Denmark. This trend is in part due to increasing myopia, increasing pseudophakia, and possibly other factors. This should be considered when planning VR services and allocating resources in the future.

show abstract

“…Gender is also a key risk factor. Several recent studies have shown Males have a greater preponderance to Idiopathic Retinal Detachment, ranging from 59–68% of all cases, compared to Females [ 17 , 18 ]. Finally, ocular trauma is a well-documented risk factor, particularly in patients who have previously undergone phacoemulsification surgery [ 19 ].…”

Section: Retinal Detachment Genetic Predispositions and Risk Factorsmentioning

confidence: 99%

The Genetic Architecture of Non-Syndromic Rhegmatogenous Retinal Detachment

Moledina

Charteris

Chandra

2022

Genes

View full text Add to dashboard Cite

Rhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment (RD), affecting 1 in 10,000 patients per year. The condition has significant ocular morbidity, with a sizeable proportion of patients obtaining poor visual outcomes. Despite this, the genetics underpinning Idiopathic Retinal Detachment (IRD) remain poorly understood; this is likely due to small sample sizes in relevant studies. The majority of research pertains to the well-characterised Mende lian syndromes, such as Sticklers and Wagners, associated with RRD. Nevertheless, in recent years, there has been an increasing body of literature identifying the common genetic mutations and mechanisms associated with IRD. Several recent Genomic Wide Association Studies (GWAS) studies have identified a number of genetic loci related to the development of IRD. Our review aims to provide an up-to-date summary of the significant genetic mechanisms and associations of Idiopathic RRD.

show abstract

Phenotype and Outcomes of Phakic Versus Pseudophakic Primary Rhegmatogenous Retinal Detachments: Cataract or Cataract Surgery Related?

Cited by 15 publications

References 36 publications

Substantial increase in the incidence of rhegmatogenous retinal detachment in Western Norway over 20 years

Substantial increase in the incidence of rhegmatogenous retinal detachment in Western Norway over 20 years

The Scottish RD survey 10 years on: the increasing incidence of retinal detachments

The Genetic Architecture of Non-Syndromic Rhegmatogenous Retinal Detachment

Contact Info

Product

Resources

About