Phenotype and metabolic profile of South Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist Endocrine Clinic

Wijeyaratne, Chandrika; Seneviratne, Ruwanthi de A.; Dahanayake, Shamalka; Kumarapeli, Vindya; Palipane, Ethusha; Kuruppu, Nadeera; Yapa, Chandrika; Seneviratne, Rohini De Alwis; Balen, Adam

doi:10.1093/humrep/deq310

Cited by 119 publications

(132 citation statements)

References 37 publications

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“…Although normal cycling hyperandrogenic women (Hyperandrogenism and PCO morphology) had a significantly lower incidence of obesity than the other phenotypes, the prevalence of metabolic syndrome was similar in all phenotypes. In contrast to a large USA study, the data of which reported a two-fold increased risk of metabolic syndrome in hyperandrogenic women, this study did not reveal any link between plasma testosterone and the occurrence of metabolic syndrome (44).…”

Section: Pathogenesis Of Metabolic Syndrome In Adolescent Pcos Womencontrasting

confidence: 99%

What do we know about metabolic syndrome in adolescents with PCOS?

Cırık

Dilbaz

2014

J Turkish German Gynecol Assoc

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Section: Pathogenesis Of Metabolic Syndrome In Adolescent Pcos Womencontrasting

confidence: 99%

What do we know about metabolic syndrome in adolescents with PCOS?

Cırık

Dilbaz

2014

J Turkish German Gynecol Assoc

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“…In a recent study looking into phenotype and metabolic profile of South Asian women with PCOS, young indigenous South Asians with PCOS have greater odds of being centrally obese compared with BMImatched controls, with a third having metabolic syndrome that bears no relationship with the androgenic phenotype. The significant predictors for metabolic syndrome within the PCOS cohort were advancing age, obesity determined by the Asian cut off (BMI O25 kg/m 2 ), and acanthosis nigricans, while family history of diabetes, hyperandrogenism, and elevated SHBG did not have any predictive value (43), suggesting that we also have to factor ethnicity into equation. However, whether metabolic syndrome confers a CVR over and above the sum of its parts is still unclear.…”

Section: Metabolic Syndrome and Pcosmentioning

confidence: 95%

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified whether there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential, thus introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood and imaging such as flow-mediated vasodilatation. In PCOS, both peripheral and central insulin resistance (IR) have been shown. Weight loss has been shown to improve IR and visceral fat, while insulin sensitizer therapies with metformin or thiazolidinediones improve IR and endothelial dysfunction. IR is also found in non-alcoholic fatty liver disease that in turn is very common in PCOS; studies have suggested that IR may be improved by treatment with metformin and omega-3 fish oils. PCOS patients have a more dyslipidemic phenotype that is worse in 'classical PCOS' associated with a higher CVR. Studies with atorvastatin and simvastatin have reported a decrease in the lipid parameters and an improvement in CVR indices including IR, but it is unclear whether this is due to their lipid-lowering action or a pleiotropic effect of the statin. In this expert opinion review, the relevant literature published during the last 2 years was considered. It focuses on some recent important data that has emerged while also exposing the gaps that remain in our knowledge that need to be addressed.

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“…Multiple studies throughout the world indicated that several factors including ethnicity might contribute to these different inferences due to genetic polymorphisms [22][23][24] stressing on the fact that the association between metabolic and neuroendocrinological abnormalities with PCOS may vary between different population groups in different areas. However, only a few studies are available from the South Asian countries and the Indian subcontinent that provided information regarding the differential relationship between the neuroendocrinological and metabolic profile among PCOS patients in these regions [25,26]. Keeping these factors in mind, we aimed to analyze the neuroendocrinological abnormalities in the PCOS patients in our population group in eastern part of the country and find out their links with metabolic parameters like insulin resistance and lipid profile, and markers for body fat distribution like BMI and WHR.…”

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confidence: 99%

Predictors of Insulin Resistance and Metabolic Complications in Polycystic Ovarian Syndrome in an Eastern Indian Population

et al. 2012

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The purpose of this study was to assess the predictive values of central obesity and hyperandrogenemia in development of insulin resistance and dyslipidemia in the polycystic ovarian syndrome (PCOS) patients in our region. Differences of fasting blood glucose level, insulin resistance index HOMA-IR, lipid parameters, waist hip ratio (WHR), body mass index, LH/FSH ratio and testosterone levels between 45 PCOS cases and 35 age matched controls were obtained. Strength of association between different parameters in the case group was assayed by Pearson's correlation analysis. Dependence of insulin resistance and WHR on different predictors was assessed by multiple linear regression assay. Total cholesterol, LDL cholesterol, LH, FSH, LH/FSH ratio, WHR and insulin resistance were significantly higher in the case group (p \ 0.05). Serum testosterone showed strong correlation with insulin resistance and LH/FSH ratio (r = 0.432 and 0.747, p = 0.01 and 0.001 respectively) in the PCOS patients while WHR and serum testosterone level stood out to be most significant predictors for the insulin resistance (b = 0.361 and 0.498; p = 0.048 and 0.049 respectively). Hyperandrogenemia and central obesity were the major factors predicting development of insulin resistance and its related metabolic and cardiovascular complications in our PCOS patients. We suggest early monitoring for androgen level and WHR in these patients for predicting an ensuing insulin resistance and modulating the treatment procedure accordingly to minimise future cardiovascular risks.

show abstract

Phenotype and metabolic profile of South Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist Endocrine Clinic

Cited by 119 publications

References 37 publications

What do we know about metabolic syndrome in adolescents with PCOS?

What do we know about metabolic syndrome in adolescents with PCOS?

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Predictors of Insulin Resistance and Metabolic Complications in Polycystic Ovarian Syndrome in an Eastern Indian Population

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