Phenotype and function of tissue-resident unconventional Foxp3-expressing CD4+ regulatory T cells

Lü, Jingli; Meng, Haiyang; Zhang, Ailing; Yang, Jie; Zhang, Xiaojian

doi:10.1016/j.cellimm.2015.06.005

Cited by 18 publications

(16 citation statements)

References 70 publications

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“…The former has a tissue-specific phenotype and is functional (29). For example, VAT-Treg cells are functional specialized tissue resident cells that depend on the transcription factor PPAR-g, limit inflammation of the skin, intestines and central nervous system and improve the sensitivity of adipose tissue to insulin (30). According to a recent study, significant differences in the transcriptional landscape, phenotype and chromatin accessibility of VAT-Treg cells exist between sexes (31).…”

Section: Classification Of Treg Cellsmentioning

confidence: 99%

Function and Role of Regulatory T Cells in Rheumatoid Arthritis

et al. 2021

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Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune diseases is the loss of tolerance to self or harmless antigens. The loss or functional deficiency of key immune cells, regulatory T (Treg) cells, has been confirmed in human autoimmune diseases. The pathogenesis of RA is complex, and the dysfunction of Tregs is one of the proposed mechanisms underlying the breakdown of self-tolerance leading to the progression of RA. Treg cells are a vital component of peripheral immune tolerance, and the transcription factor Foxp3 plays a major immunosuppressive role. Clinical treatment for RA mainly utilizes drugs to alleviate the progression of disease and relieve disease activity, and the ideal treatment strategy should be to re-induce self-tolerance before obvious tissue injury. Treg cells are one of the ideal options. This review will introduce the classification, mechanism of action, and characteristics of Treg cells in RA, which provides insights into clinical RA treatment.

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Section: Classification Of Treg Cellsmentioning

confidence: 99%

Function and Role of Regulatory T Cells in Rheumatoid Arthritis

et al. 2021

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“…Recent work has led to the identification of specialized subsets of Tregs, which reside in peripheral tissues, including skin, intestinal mucosa, adipose tissue, autoimmune target tissues, and injured muscle ( 66 ). Although tissue-resident Tregs represent a small fraction of total Tregs, their peculiar phenotype and function confer the ability to regulate tissue-specific physiological and pathological processes.…”

Section: Open Issues In Treg-based Immunotherapymentioning

confidence: 99%

Clinical Outlook for Type-1 and FOXP3+ T Regulatory Cell-Based Therapy

Gregori

Passerini

Roncarolo³

2015

Front. Immunol.

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T regulatory cells (Tregs) are subsets of T lymphocytes specialized in modulating antigen-specific immune responses in vivo. Hence, Tregs represent an ideal therapeutic tool to control detrimental immune reactions. Based on solid pre-clinical results, investigators started testing the safety and efficacy of Treg-based therapies in humans. Despite promising results, a number of issues remain to be solved. We will discuss the results obtained from clinical trials and the challenges and risks we are facing in the further development of Treg-based therapies.

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“…[80]. Theoretically, therapy with these tissue-specific cells can limit the activity of medicinal Tregs to the site of infection and reduce further possible adverse effects elsewhere [81]. Indeed, what is the suppressive nature of the cells?…”

Section: Perspectives For Future Clinical Usementioning

confidence: 99%

Cell-Based Therapies with T Regulatory Cells

2017

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CD4+CD25highFoxP3+ T regulatory cells (Tregs) are immunodominant suppressors in the immune system. Tregs use various mechanisms to control immune responses. Preclinical data from animal models have confirmed the huge therapeutic potential of Tregs in many immune-mediated diseases. Hence, these cells are now on the road to translation to cell therapy in the clinic as the first clinical trials are accomplished. To date, clinical research has involved mainly hematopoietic stem cell transplantations, solid organ transplantations, and autoimmunity. Despite difficulties with legislation and technical issues, treatment is constantly evolving and may soon represent a valid alternative for patients with diseases that are currently incurable. This review focuses on the basic and clinical experience with Tregs with adoptive transfer of these cells, primarily from clinical trials, as well as on perspectives on clinical use and technical problems with implementing the therapy.

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Phenotype and function of tissue-resident unconventional Foxp3-expressing CD4+ regulatory T cells

Cited by 18 publications

References 70 publications

Function and Role of Regulatory T Cells in Rheumatoid Arthritis

Function and Role of Regulatory T Cells in Rheumatoid Arthritis

Clinical Outlook for Type-1 and FOXP3+ T Regulatory Cell-Based Therapy

Cell-Based Therapies with T Regulatory Cells

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