Phenothiazines: Neurochemical Aspects of Their Mode of Action

Gabay, Sabit

doi:10.1007/978-1-4615-7175-9_12

Cited by 3 publications

(2 citation statements)

References 102 publications

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“…Chlorpromazine (CPZ), a derivative of phenothiazine, shows diverse actions on metabolic processes (1) and is a remarkable photosensitizing compound in the dermatological area (2)(3)(4)(5). To understand the reaction mechanism of this drug on the molecular level, it is important to study the interaction between CPZ and biomolecules such as coenzymes and proteins.…”

Section: Introductionmentioning

confidence: 99%

A Study of the Interaction Between Chlorpromazine and Riboflavin Binding Protein

Shiga¹,

Matsumoto²,

Ueda³

et al. 1983

The Journal of Dermatology

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The interaction between chlorpromazine (CPZ) and riboflavin binding protein (RBP) was. studied by the spectrophotometric and spectrofluorometric methods.CPZ combined with RBP in a I: 1 molar ratio and the dissociation constant was determined to be 3.8 x 1O-5M at pH 7, 25°C. F1avins such as riboflavin (Rf) and lumiflavin were released from the complexes with RBP by the addition of CPZ. The mechanism of flavin-release was mainly competitive binding between CPZ and a isoalloxazine ring of flavins to RBP.The mechanism of some biological phenomena induced by CPZ was discussed based on the flavin-CPZ interaction.Abbreviations: CPZ, chlorpromazine; Rf, riboflavin; RBP, riboflavin binding protein; FAD, flavin adenine dinucleotide.

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Section: Introductionmentioning

confidence: 99%

A Study of the Interaction Between Chlorpromazine and Riboflavin Binding Protein

Shiga¹,

Matsumoto²,

Ueda³

et al. 1983

The Journal of Dermatology

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“…Although it is possible that the antipsychotic effects of phenothiazines, as well as their extrapyramydal side effects, are related to their specific effects on the dopaminergic system (27), these drugs also have a wide range of effects on many biological systems. Chlorpromazine has a general inhibitory effect on permeability of biological membranes and it affects a variety of enzymatic processes, such as the uncoupling of oxidative phosphorylation and inhibition of ATP-ase (17). It is not surprising that they cause undesirable side effects on the CNS and on other systems and organs.…”

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confidence: 99%