Phenothiazine Derivatives: Di-oxygenated Compounds

Houston, D. F.; Kester, E. B.; DeEds, Floyd

doi:10.1021/ja01179a068

Cited by 14 publications

(6 citation statements)

References 8 publications

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“…(iii) More interesting results were obtained by the sulfur fusion of p., p»-dihydroxydiphenylamine process of Houston et al (34). The original process gave a dark-blue amorphous mass, which did not melt 6.…”

Section: Purification Of Phenothiazine and Production Of Its Oxidation Derivativesmentioning

confidence: 94%

The Metabolism of Phenothiazine in Chickens

Platonow¹,

Oliver²

1960

Research in Veterinary Science

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Purification of Phenothiazine find Production of its Oxidation Derivatives. 3 Chromatography and Spectrophotometry of Phenothiazine and its Derivatives. 8 Chromatography and Spectrophotometry of Phenothiazine and its Derivatives after Extraction from the Body, Isolation of the Metabolites from Bile, 14 Isolation and Identification of Phenothiazine and its Metabolites in the Caecal Contents, Isolation and Identification of Phenothiazine and its Metabolites in Excreta, RESULTS

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Section: Purification Of Phenothiazine and Production Of Its Oxidation Derivativesmentioning

confidence: 94%

The Metabolism of Phenothiazine in Chickens

Platonow¹,

Oliver²

1960

Research in Veterinary Science

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“…Preparative.-Phenothiazone, thionol, and phenothiazine sulphoxide were prepared by the methods of Olivier and Combe (1950), Houston, Kester, and DeEds (1949), and Barnett and Smiles (1909) respectively.…”

Section: Methodsmentioning

confidence: 99%

THE EFFECT OF SOME OXIDATION PRODUCTS OF PHENOTHIAZINE ON LIVER FLUKE (FASCIOLA HEPATICA) IN VITRO

Mackie

Raeburn

1952

British Journal of Pharmacology and Chemotherapy

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“…50.0mCi/mol; radiochemical purity > 98%) which did not depress a mixed melting point with the authentic compound. Phenothiazone (phenothiaz-3-one) was synthesized by oxidation of phenothiazine with ferric chloride (Pummerer andGabner 1913, Grannick, Michaelis andSchubert 1940) and thionol (7-hydroxyphenothiaz-3-one) by oxidation with sulphuric acid (Grannick andMichaelis 1947, Houston, Kester andDeEds 1949). Both were purified by column chromatography on aluminium oxide columns, phenothiazone being eluted with chloroform and thionol with 1.8 M ammonium hydroxide.…”

Section: Chemicalsmentioning

confidence: 99%

The metabolism of phenothiazine in the neonatal calf: Identification of drug-polypeptide conjugates from urine

Waring¹,

Mitchell²

1985

Xenobiotica

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The presence of a polypeptide conjugate fraction in the urine of young calves after oral dosing with phenothiazine has been confirmed. Four different polypeptide conjugates, containing up to six amino acids attached to phenothiazine or leucophenothiazone via the carboxyl terminal of the chain, have been isolated, characterized and sequenced. In addition, several minor polypeptide conjugates have been observed. The literature pertaining to polypeptide conjugates of drugs has been reviewed and the importance of this metabolic route in neonatal animals discussed.

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Phenothiazine Derivatives: Di-oxygenated Compounds

Cited by 14 publications

References 8 publications

The Metabolism of Phenothiazine in Chickens

The Metabolism of Phenothiazine in Chickens

THE EFFECT OF SOME OXIDATION PRODUCTS OF PHENOTHIAZINE ON LIVER FLUKE (FASCIOLA HEPATICA) IN VITRO

The metabolism of phenothiazine in the neonatal calf: Identification of drug-polypeptide conjugates from urine

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