Phenosafranin-Based Colorimetric-Sensing Platform for Nitrite Detection Enabled by Griess Assay

Hou, Jingzhou; Wu, Huixiang; Shen, Xin; Zhang, Chao; Hou, Changjun; He, Qiang; Huo, Danqun

doi:10.3390/s20051501

“…28 Phenosafranin has been proven to be an effective probe molecule for sodium nitrite detection. 8,29 In this experiment, the quantification of nitrite in both standard solutions and meat products was achieved by monitoring changes in the intensity of characteristic Raman peaks of phenosafranin during its reaction with sodium nitrite. The overall detection process, as shown in Fig.…”

Section: Sers Detection Of Sodium Nitritementioning

confidence: 99%

“…In the SERS spectrum, only changes in the original characteristic peaks of phenosafranin were observed, affirming that phenosafranin just underwent conformational changes. The amino group (-NH 2 ) on phenosafranin underwent diazotization (-NvN + ) 29 during this process. Additionally, in the presence of high concentrations of nitrite, a significant decrease in the intensity of the characteristic peak at 1640 cm −1 (H-N-H plane bending) was observed.…”

Section: Synthesis and Characterization Of Aunps And Aunps-alginate H...mentioning

confidence: 99%

A simple and efficient alginate hydrogel combined with surface-enhanced Raman spectroscopy for quantitative analysis of sodium nitrite in meat products

Liang,

Huang,

Miao

et al. 2024

Analyst

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0

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The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection

Antón-Cánovas

¹

,

Alonso

²

2022

Angewandte Chemie

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C-H bond formylation is the most immediate way to incorporate the versatile formyl group into (hetero)aromatics. However, the type of reagents and severe conditions involved in the classical formylation methods often curtail their application, especially in the presence of other functional groups. Herein, we present the Eschenmoser's salt, a commercially available (dimethylamino)methylating chemical, as a useful reagent for the C-H formylation of indolizines and other compounds. The method is straightforward and mild, furnishing indolizinecarbaldehydes in modest-to-good yields with exclusive and remote regioselectivity. Furthermore, these compounds can be easily transformed into pushpull dyes and are highly selective in the colorimetric detection of nitrite, a substance extensively employed as preservative in the food industry, the concentration of which is crucial to control to prevent harmful effects in living organisms. The assay is simple, allowing the naked-eye detection of nitrite in solution or on a cotton swab for a wide range of concentrations.

show abstract

The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection

Antón-Cánovas

¹

,

Alonso

²

2022

View full text Add to dashboard Cite

C-H bond formylation is the most immediate way to incorporate the versatile formyl group into (hetero)aromatics. However, the type of reagents and severe conditions involved in the classical formylation methods often curtail their application, especially in the presence of other functional groups. Herein, we present the Eschenmoser's salt, a commercially available (dimethylamino)methylating chemical, as a useful reagent for the C-H formylation of indolizines and other compounds. The method is straightforward and mild, furnishing indolizinecarbaldehydes in modest-to-good yields with exclusive and remote regioselectivity. Furthermore, these compounds can be easily transformed into pushpull dyes and are highly selective in the colorimetric detection of nitrite, a substance extensively employed as preservative in the food industry, the concentration of which is crucial to control to prevent harmful effects in living organisms. The assay is simple, allowing the naked-eye detection of nitrite in solution or on a cotton swab for a wide range of concentrations.

show abstract

Phenosafranin-Based Colorimetric-Sensing Platform for Nitrite Detection Enabled by Griess Assay

Cited by 7 publications

References 42 publications

A simple and efficient alginate hydrogel combined with surface-enhanced Raman spectroscopy for quantitative analysis of sodium nitrite in meat products

A simple and efficient alginate hydrogel combined with surface-enhanced Raman spectroscopy for quantitative analysis of sodium nitrite in meat products

The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection

The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection

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