Phenomenology of bubble-collapse-driven penetration of biomaterial-surrogate liquid-liquid interfaces

Abstract

The paper presents phenomenology of interaction and penetration of liquid-liquid material interfaces initiated by shock-driven collapse of single and multiple microbubbles situated near the material interface. Previous experimental studies have established such a generic setting as relevant for the investigation of sonoporation, i.e., the perforation of live cells by microbubble collapses. We consider a planar or spherical, single-or dual-layer, material interface between a gelatin material and water. A single or several ideal-gas microbubbles are positioned near the interface. Bubble collapse is initiated by a shock wave with a pressure profile specific to laser generation and is flat when hitting the gas-water interface. The interfacial acoustic impedance match singles out the collapseinduced re-entrant jet as main event. High-resolution sharp-interface numerical methods are employed to ensure that wave dynamics, hydrodynamics, and interface transporting are accurately resolved. Bubble configurations are varied between single and double and between attached and with standoff distance. Parameters varied are shock-wave peak pressure and viscosity ratio between single and double layers of gelatin and the surrounding water. For inertia-dominated cases, two regimes are observed, the first characterized by linear growth of the penetration depth and the second by a t 2/3 scaling. The latter range is affected by viscosity which reduces penetration speed. The results show that process parameters, in particular shock overpressure, control not only penetration depth but also the size of the interface perforation, indicating means to steer processes in biomedical applications.

An assessment of multicomponent flow models and interface capturing schemes for spherical bubble dynamics

“…Amongst other features, cavitation involves the growth and collapse of a gas bubble in a liquid. Many applications require a detailed understanding of this process in or near soft materials, including biological tissues for medical purposes [4][5][6][7][8] and polymeric coatings and biofouling in industry [9]. Preliminary studies have shown that bubble dynamics are sensitive to the properties of these materials [10,11], motivating a comprehensive multi-scale theory capable of predicting complex bubble cavitation.…”

From advanced aircraft design to drug delivery

“…multiphase phenomena like the transient perforation of biomaterial. A highlight result was the study of the interaction and penetration of liquidliquid material interfaces initiated by the shock-driven collapse of single and multiple microbubbles situated near the material interface (Figure 2, Pan et al, 2018). This generic surrogate model was shown to adequately represent the relevant physics of sonoporation, the perforation of living cells by microbubble collapses.…”

Hybrid quadrature moment method for accurate and stable representation of non-Gaussian processes and their dynamics

“…Focused shockwaves can cavitate bubbles that ablate kidney stones during lithotripsy treatment [14,45]. Their interaction with biological tissue or manufactured soft materials also attracts the medical [7,15,39,40,50] and material science communities [4,18,52]. Bubble cavitation is also responsible for damage and noise in hydraulic pipe systems [51,56], hydro turbines [16,28,32], and propellers [23,48].…”