Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health
Seyedeh Maryam Zekavat,
Saman Doroodgar Jorshery,
Franziska G. Rauscher
et al.
Abstract:The human retina is a multilayered tissue that offers a unique window into systemic health. Optical coherence tomography (OCT) is widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy in exquisite detail. We conducted genotypic and phenotypic analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed OCT layer cross-phenotype association analyses (OCT-XWAS), associating retinal thicknesses with 1866 incident conditions (median… Show more
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