Phenols with Anti-HIV Activity from<i>Daphne acutiloba</i>

Huang, Sheng; Zhang, Xing Jie; Li, Xing Yao; Jiang, Huifen; Qing, Yun; Wang, Peng Cheng; Liu, Yu Qing; Hu, Jiang; Zheng, Yong; Zhou, Jun; Zhao, You Xing

doi:10.1055/s-0031-1280263

Cited by 20 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, it is known to inhibit tumor cell invasion and metastasis [20]. Caffeic acid has antiulcer [21], anti-inflammatory [22] antioxidant [23] and anti-HIV [24] activities.…”

Section: Introductionmentioning

confidence: 99%

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

Korkor¹,

Mohamed²,

Kafie³

et al. 2017

IOSRJPBS

View full text Add to dashboard Cite

“…Also, it is known to inhibit tumor cell invasion and metastasis [20]. Caffeic acid has antiulcer [21], anti-inflammatory [22] antioxidant [23] and anti-HIV [24] activities.…”

Section: Introductionmentioning

confidence: 99%

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

Korkor¹,

Mohamed²,

Kafie³

et al. 2017

IOSRJPBS

View full text Add to dashboard Cite

“…Although 1,5-diphenylpentan-1,3-dione has not yet been reported from nature, one of its analogues, 1-hydroxy-1,5-diphenylpentan-3-one, has been found from agarwood, and another, 3-hydroxy-1,5-diphenylpentan-1-one, has been found from the medicinal plant Daphne acutiloba Rehd. (Thymelaeceae) [ 29 ], which possess obvious structural similarities with PECs except for a γ-pyrone ring. Referring to the chemoenzymatic results of HsPKS3 carried out in vitro by Wang et.al [ 30 ], coincubation of HsPKS3 with 2-hydroxybenzoyl-CoA and 3-oxo-5-phenylpentanoic acid led to the formation of a small amount of 2-(2-phenylethyl)chromone, while condensation of benzoyl-CoA, malonyl-CoA and p -hydroxyphenylpropinoyl-CoA only produced a diarylpentanoid, which suggests a hydroxy group at the C-2 position may be a prerequisite for the ring closure of the diarylpentanoid scaffold.…”

Section: Resultsmentioning

confidence: 99%

Monitoring the Chemical Profile in Agarwood Formation within One Year and Speculating on the Biosynthesis of 2-(2-Phenylethyl)Chromones

et al. 2018

View full text Add to dashboard Cite

Agarwood is highly valued for its uses as incense, perfume, and medicine. However, systematic analyses of dynamic changes of secondary metabolites during the process of agarwood formation have not yet been reported. In this study, agarwood was produced by transfusing the agarwood inducer into the trunk of Aquilaria sinensis, and changing patterns of chemical constituents, especially 2-(2-phenylethyl)chromones (PECs), in wood samples collected from the 1st to 12th month, were analyzed by GC-EI-MS and UPLC-ESI-MS/MS methods. Aromatic compounds, steroids, fatty acids/esters, sesquiterpenoids, and PECs were detected by GC-MS, in which PECs were the major constituents. Following this, UPLC-MS was used for further comprehensive analysis of PECs, from which we found that 2-(2-phenylethyl)chromones of flindersia type (FTPECs) were the most abundant, while PECs with epoxidated chromone moiety were detected with limited numbers and relatively low content. Speculation on the formation of major FTPECs was fully elucidated in our context. The key step of FTPECs biosynthesis is possibly catalyzed by type III polyketide synthases (PKSs) which condensate dihydro-cinnamoyl-CoA analogues and malonyl-CoA with 2-hydroxy-benzoyl-CoA to produce 2-(2-phenyethyl)chromone scaffold, or with 2,5-dihydroxybenzoyl-CoA to form FTPECS with 6-hydroxy group, which may serve as precursors for further reactions catalyzed by hydroxylase or O-methyltransferase (OMT) to produce FTPECs with diverse substitution patterns. It is the first report that systematically analyzed dynamic changes of secondary metabolites during the process of agarwood formation and fully discussed the biosynthetic pathway of PECs.

show abstract

“…acutiloba , showed that the main types of natural products from this genus were terpenoids including sesquiterpenoids and diterpenoids, biflavonoids, and lignans . These compounds possessed extensive pharmacological activities as antitumor, antifeedant, anti‐inflammation, and anti‐HIV‐1 . The previous chemical studies on D .…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from the Stems of Daphne holosericea (Diels) Hamaya

Chen

Huang

et al. 2016

Chemistry & Biodiversity

View full text Add to dashboard Cite

Two new compounds, one flavanol dimer dapholosericol A (1) and one tigliane diterpene dapholosericin A (2), together with ten known ones, were isolated from the AcOEt extract of Daphne holosericea (Diels) Hamaya. Their structures were elucidated by their spectroscopic data analysis. Compounds 1 and 2 showed moderate activities against acetylcholinesterase with inhibition ratio of 36% and 29% at a concentration of 100 μmol/l, respectively.

show abstract

Phenols with Anti-HIV Activity fromDaphne acutiloba

Cited by 20 publications

References 18 publications

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

Monitoring the Chemical Profile in Agarwood Formation within One Year and Speculating on the Biosynthesis of 2-(2-Phenylethyl)Chromones

Chemical Constituents from the Stems of Daphne holosericea (Diels) Hamaya

Contact Info

Product

Resources

About