Phenolphthalein tolerance in childhood

Blatt, Maurice L.; Steigmann, Frederick; Dyniewicz, J. M.

doi:10.1016/s0022-3476(43)80228-6

The Journal of Pediatrics

1943

DOI: 10.1016/s0022-3476(43)80228-6

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Phenolphthalein tolerance in childhood

Maurice L. Blatt

Frederick Steigmann

J. M. Dyniewicz

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1944

1991

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Cited by 9 publications

(1 citation statement)

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“…His cerebrospinal fluid contained 50 lymphocytes per c.mr. Improvement was slow, but eventually it was complete.In addition to cases in which its ingestion has been followed by toxic effects, many cases have been reported in which relatively enormous amounts of phenolphthalein have been taken with no untoward effects (Blatt, Steigmann, and Dyniewicz, 1943). While it is clear, therefore, that phenolphthalein does not exert a direct toxic action, the welldocumented reports of skin reactions indicate that it is capable of producing a hypersensitivity reaction.…”

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confidence: 99%

Fatal Case of Encephalitis After Phenolphthalein Ingestion

Kendall¹

1954

BMJ

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TALC PNEUMOCONIOSIS BRISHr 1461 tions revealed no abnormality in the levels of his total and differential white count. His serum alkaline phosphatase, serum proteins, albumin/globulin ratio, serum calcium, P.C.V., and E.S.R. were within normal limits. His maximum breathing capacity was 62.5 litres a minute and his vital capacity 1,700 c.cm. A chest x-ray film showed small areas of nodulation scattered fairly uniformly throughout all zones of both lung fields (see Fig.). These nodularRadiograph showing small areas of nodulation in both lung fields.shadows were closely packed, and under the hand lens appeared to be of fairly homogeneous density. There was also evidence of a lattice-or matrix-work background on which the nodular deposits were superimposed. In the right upper lobe, apex, and first space there was evidence of a diffuse opacity suspiciously like pulmonary tuberculosis. Radiologically the findings were thought to be those of talc pneumoconiosis probably complicated by apical pulmonary tuberculosis.Occupational History.-This patient had been employed for 43 years (starting at 14 years of age) in the textile industry. His occupation was that of picker maker. These employees are concerned in making thongs, originally of buffaio hide, but in recent years from any type of leather skin. The picker is employed to drive the shuttle which threads the weft in the weaving loom from side to side.The hide is first steeped in a vat of water for three hours and is then hung up for five minutes to allow the surplus fluid to drain off. It is next placed on old-sacking on the floor and dusted liberally with talc (French chalk, hydrated magnesium silicate). The talc is now spread uniformly on the hide by means of a whitewash brush. The hide is then reversed and the process repeated. Later the hide is lifted by two picker makers on to a table, and throughout these operations the atmosphere is cloudy with fine talc dust. Each week about 40 hides, each 12 by 6 ft. (3.6 by 1.8 metres) in size, are treated in this fash on by each picker maker. It was after working 39 years in this process that the patient began to observe the symptoms indicated above. DiscussionPetrographically, talc consists of straight fibres, curved fibres, and shreds. These fibres measure up to 10 M in length, though many are only 4 to 5 it. Radiological evidence of talc plaques varying from single linear strands in the region of the diaphragm to massive deposits, bizarre in shape, extending over a large part of the lung fields, has been recorded by Siegal et al. (1943). There is no certain association between talc pneumoconiosis and pulmonary tuberculosis, though Thorel (1896) and Zanelli (1931) have recorded cases in which these two conditions were probably present.It is of interest to observe that the allied condition of talc granuloma has been reported, both in the U.S. and in the British literature (Mackey and Gibson, 1948; Walker, 1948; and Smith, 1948), as occurring in abdominal and gynaecological surgery, following the use of talc or French cha...

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Fatal Case of Encephalitis After Phenolphthalein Ingestion

Kendall¹

1954

BMJ

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Laxatives: Chemical Structure and. Potency of Phthaleins and Hydroxyanthraquinones

Hubacher¹,

Doernberg²,

Horner³

1953

Journal of the American Pharmaceutical Association (Scientific

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�ber eine �berempfindlichkeit gegen Phenolphthalein, die einen Lupus erythematodes disseminatus vort�uschte

Lewin

1963

Archiv f�r Toxikologie

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Phenolphthalein tolerance in childhood

Cited by 9 publications

References 6 publications

Fatal Case of Encephalitis After Phenolphthalein Ingestion

Fatal Case of Encephalitis After Phenolphthalein Ingestion

Laxatives: Chemical Structure and. Potency of Phthaleins and Hydroxyanthraquinones

�ber eine �berempfindlichkeit gegen Phenolphthalein, die einen Lupus erythematodes disseminatus vort�uschte

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