Phenolics-rich extracts of Nauclea latifolia fruit ameliorates lead acetate-induced haematology and lung tissues toxicity in male Wistar rats

Busari, Musa Bola; Hamzah, Rabiat Unekwu; Muhammad, Hadiza Lami; Yusuf, Ruqayyah S.; Adeniyi, Jamiu Olabanji; Ibrahim, Yunusa Olatunji; Adakole, Jennifer Onyowo

doi:10.1016/j.sciaf.2020.e00686

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…As such, higher antioxidant activity of methanol/acetone phenolic-rich extract could be due to its higher phenolics content. This result agrees with the report of Busari et al [11] who reported higher phenolics content (phenols, flavonoids and tannins) of methanol/acetone extract of NLF than its methanol extract. The higher activities (in vivo) of MAPR actually corresponds to its antioxidant activities (in vitro) which could be through stabilization of free radicals or metal chelation (by donating hydrogen atom or electron to the free radical) which depend on quantity of phenolic compounds present in the extract.…”

Section: Discussionsupporting

confidence: 93%

“…Phenolics are known to serve as reducing agents, metal chelators, singlet oxygen quenchers, radical scavengers and hydrogen donors [10]. However, in order to extract maximum quantity of these secondary metabolites from several plants, selected solvents of different polarities must be used coupled with suitable method of phytoconstituent extraction [11].…”

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confidence: 99%

“…Our previous study showed that phenolic-rich extracts of N. latifolia fruit ameliorates lead acetate-induced haematology and lung tissues toxicity in male Wistar rats [11]. Therefore, it is not out of place to evaluate the restorative effects of phenolics rich-extracts from N. latifolia fruit on lead acetate-induced liver and kidney damage in Wistar rats via changes in liver damaged markers, kidney damaged markers as well as the histology of both organs.…”

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confidence: 99%

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Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

et al. 2021

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Liver and kidney diseases are becoming order of the day in both developed and developing countries as a result of environmental pollutants such as lead. Restorative activities of methanol and methanol/acetone phenolic-rich extracts (MPR and MAPR, respectively) of the N. latifolia fruit (NLF) on lead acetate-induced liver and kidney damaged were assessed in Wistar rats. The antioxidant activities of both phenolic-rich extracts of NLF were also carried out using standard methods. Seven groups of Wistar rats comprising of 5 rats each were used for the study and 1000 mg/kg body weight (bw.) of lead acetate solution was administered orally to the 6 groups of animals to induce liver and kidney damage. The high and low dosages of 300 and of 150 mg/kg body weight (bw.) of both MPR and MAPR were administered orally to four groups for 14 days along positive (100 mg/kg bw. of silymarin), negative (treated with the placebo) and naïve control (non-induced). The percentage DPPH radical scavenging activities, ferric reducing antioxidant power and percentage inhibition of lipid peroxidation show high antioxidants activities dose-dependently. Furthermore, administration of lead acetate significantly (p > 0.05) reduces the weight gain and elevates the liver and kidney relative weight as well as their respective damage biomarkers with distortions in their histologies. However, treatment with MPR and MAPR resulted in significant (p < 0.05) improve in the percentage body weight gain, relative liver and kidney weight as well as restoration of the activities of the liver and kidney functions biomarkers of the treated animals. Likewise, lesser hepatic and renal cells injury were also observed in the treated groups with MAPR being more active at high dosage which significantly (p < 0.05) compared well with normal group. Hence, the phenolics content of the N. latifolia fruit can be exploited further for drug development for the management kidney and liver damage arise from lead-induced toxicity.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

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confidence: 99%

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Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

et al. 2021

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“…From the results of this study, the effects of ethanolic extract of Nauclea latifolia on haematological parameters of the experimental rats after 42 days of administration showed a significant elevation (p<0.05) in Packed Cell Volume (PCV), white blood cell count, haemoglobin concentration, red blood cell count and the white blood cell differentials compared to the control group which could be a protective mechanism against infection. This observation was in agreement with Ismaeel et al 11 , Mukinda and Syce 12 , Awodu et al 13 and in concordance with Busari et al 14 in which methanol and methanol/acetone phenolic-rich extracts of Nauclea latifolia was able to restore haematological abnormalities as well as sustain the integrity of lung tissues of experimental rats. However, this finding was not in agreement with the report of Olusola et al 15 where the observed decrease in RBC count, Hb and PCV was assumed to be associated with retarded haemopoeisis, destruction and shrinkage of RBC after the administration of mistletoe from three host plants i.e.…”

Section: Discussionsupporting

confidence: 90%

Effects of Nauclea latifolia Ethanolic Root Extract on Haematological Indices in Rats

Chukwuka,

Nwadiogbu,

Yakubu

et al. 2023

Int. J. Biol. Chem

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Background and Objective: Nauclea latifolia (Smith) (Family: Rubiaceae) also known as 'Pincushion Tree' or 'African Peach' is a struggling shrub, native to tropical Africa and Asia where the use of folk medicine is prevalent and the search for an herbal cure is but common practice. Consequently, the effect of Nauclea latifolia ethanolic root extracts on hematological indices in rats was investigated in this research. Materials and Methods: The root of Nauclea latifolia was extracted with ethanol. A total of twenty Wister albino rats were used in this study. The rats were randomly divided into 4 groups of 5 rats each. Varying doses of the extract such as 10, 50 and 250 mg kgG 1 were orally administered to groups 2, 3 and 4, respectively for 42 days. Results: The ethanolic extract of N. latifolia showed a significant elevation (p<0.05) in haematological parameters of the experimental rats after 42 days of administration in the Packed Cell Volume (PCV), white blood cell count, hemoglobin concentration and red blood cell count as compared with the control group which could be a protective mechanism against infection. Conclusion:If the results obtained from this study are applicable to man, ethanolic extracts of Nauclea latifolia root can be used as immune boosters and blood tonics in herbal medicine. However, it seems that it may contain particles that may exert or have allergenic and inflammatory properties.

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“…TMs, due to their tendency to bioaccumulate, are found to be very hard to metabolize in an organism. Various studies reported that TMs can negatively influence a great spectrum of human organs such as the lungs [ 164 ], bladder [ 165 ], heart [ 166 , 167 ], kidney, and liver [ 168 ], and can be responsible for exhibiting anti-androgenic activity [ 169 ] and induce haematological and histopathological changes [ 170 ]. Therefore, TMs have been classified in the top 20 list of dangerous substances by ATSDR [ 171 ].…”

Section: Environment As a Source Of Bread Chemical Contaminantsmentioning

confidence: 99%

Chemical Contamination in Bread from Food Processing and Its Environmental Origin

Maher

Nowak²

2022

Molecules

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Acrylamide (AA), furan and furan derivatives, polycyclic aromatic amines (PAHs), monochloropropanediols (MCPDs), glycidol, and their esters are carcinogens that are being formed in starchy and high-protein foodstuffs, including bread, through baking, roasting, steaming, and frying due to the Maillard reaction. The Maillard reaction mechanism has also been described as the source of food processing contaminants. The above-mentioned carcinogens, especially AA and furan compounds, are crucial substances responsible for the aroma of bread. The other groups of bread contaminants are mycotoxins (MTs), toxic metals (TMs), and pesticides. All these contaminants can be differentiated depending on many factors such as source, the concentration of toxicant in the different wheat types, formation mechanism, metabolism in the human body, and hazardous exposure effects to humans. The following paper characterizes the most often occurring contaminants in the bread from each group. The human exposure to bread contaminants and their safe ranges, along with the International Agency for Research on Cancer (IARC) classification (if available), also have been analyzed.

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Phenolics-rich extracts of Nauclea latifolia fruit ameliorates lead acetate-induced haematology and lung tissues toxicity in male Wistar rats

Cited by 4 publications

References 17 publications

Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

Effects of Nauclea latifolia Ethanolic Root Extract on Haematological Indices in Rats

Chemical Contamination in Bread from Food Processing and Its Environmental Origin

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