Phenolics from Physalis peruviana fruits ameliorate streptozotocin-induced diabetes and diabetic nephropathy in rats via induction of autophagy and apoptosis regression

Ezzat, Shahira M.; Abdallah, Heba M. I.; Yassen, Noha N.; Radwan, Rasha Ali; Mostafa, Eman S.; Salama, Maha M.; Salem, Mohamed A.

doi:10.1016/j.biopha.2021.111948

Cited by 26 publications

(21 citation statements)

References 78 publications

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“…The ascorbic acid, carotenoid, and TPCs and the % DPPH inhibition of the yogurt drink supplemented with golden berry juice increased as the supplementation ratio increased, compared with the control yogurt drink (Table 3). This may be due to the high ascorbic acid, carotenoid, and TPC of the golden berry fruit and juice [23,55]. These results agreed with those reported by Dimitrellou et al [11], who found that the TPC and radical scavenging activity of yogurt increased after the fortification of yogurt milk with juices from grapes and berries.…”

Section: Titratable Acidity Ph Values Tpc and % Dpph Inhibition Of A ...supporting

confidence: 89%

“…One of those candidate plants is Physalis peruviana L. or P. pubescens L., which is known locally in Egypt as harankash and in English-speaking countries as the golden berry. This fruit has many medicinal and edible uses [22], as it contains many active components, such as vitamins A, B, C, E and K, minerals, polyunsaturated fatty acids, carbohydrates, hydroxyester disaccharides, withanolides (steroidal lactones), carotenoids, phenolic acids (such as gallic, chlorogenic, ferulic, caffeic, and p-coumaric acids), flavonoids (such as myricetin, kaempferol, catechin, quercetin, and rutin), and epicatechin biologically active components that reduce the risk of certain diseases and provide health benefits (such as antiproliferative effects on hepatoma cells, anti-hepatotoxic effects, and anti-inflammatory activity) [23]. In addition, it has excellent potential as a food-based strategy to manage hypertension and diabetes [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Production of a Yogurt Drink Enriched with Golden Berry (Physalispubescens L.) Juice and Its Therapeutic Effect on Hepatitis in Rats

et al. 2022

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Fermented dairy products have been associated with multiple health benefits. The present study aimed to produce a functional yogurt drink fortified with golden berry juice and assess its therapeutic effect on hepatitis rats. Thirty male albino rats were randomly divided into two major groups. The first group included the control (-) animals (six rats) and was fed a standard diet, whereas the second group included 24 rats that were fed a standard diet and injected with carbon tetrachloride (CCl4) for 2 weeks to trigger chronic damage of the liver (hepatitis); they were then divided into four groups (six rats/group): Group 2: hepatitis, fed on a standard diet as a positive control group; Group 3: received a basal diet with 5 mL of the yogurt drink; Group 4: received a basal diet with 5 mL of the yogurt drink fortified with 10% golden berry juice. Group 5: received a basal diet with 5 mL of the yogurt drink fortified with 20% golden berry juice. Various biological parameters were determined. Yogurt drink treatments were evaluated for their chemical, phytochemical, and sensory properties, as well as for their effects on hepatoprotective activity by determining various biochemical parameters. We found that the yogurt drinks containing golden berry juice exhibited no significant differences in fat, protein, and ash content compared with the control samples. Moreover, the yogurt drinks containing golden berry juice exhibited the highest content of total phenolic compounds, antioxidant activity, and organoleptic scores among all treatments. In addition, rats fed on a diet fortified with yogurt drinks containing golden berry juice for 8 weeks exhibited higher potential hepatoprotective effects compared with the liver injury control group. This improvement was partly observed in the group that received the yogurt drink containing golden berry juice. Therefore, we concluded that golden berry juice can be recommended as a natural additive in the manufacture of functional yogurt drinks, as it showed a potential hepatoprotective effect in rats with hepatitis.

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Section: Titratable Acidity Ph Values Tpc and % Dpph Inhibition Of A ...supporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Production of a Yogurt Drink Enriched with Golden Berry (Physalispubescens L.) Juice and Its Therapeutic Effect on Hepatitis in Rats

et al. 2022

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“…Moreover, the EtOAc extract showed remarkable α-amylase, β-glucosidase, and lipase inhibitory effects. In an in vivo antihyperglycemic test with streptozotocin (STZ)-induced diabetic rats, the EtOAc extract decreased the blood glucose level, prevented the reduction of body weight, and improved serum indicators of kidney injury [70].…”

Section: Leavesmentioning

confidence: 99%

Poorly Investigated Ecuadorian Medicinal Plants

Armijos

Ramírez

Vidari

2022

Plants

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Ecuador has, in proportion of its size, one of the richest floras of Latin America and the world; the country also has an immense cultural heritage due to the presence of different ethnic groups that have implemented the use of many wild and cultivated plants, mainly as medicinal remedies. In a recent publication, we have summarized the results of research activities recently carried out on about 120 plants native to Ecuador, which includes the structures of non-volatile isolated compounds, as well as the chemical composition of essential oils (EOs) and the in vitro tested biological activity data. For the sake of completeness, we have collected in this paper the main information obtained from recent ethnobotanical investigations on other important Ecuadorian medicinal plants for which phytochemical, pharmacological, and toxicological studies are, however, still largely lacking. Thus, one of the objectives of this paper is to preserve the traditional knowledge of Ecuadorian Indigenous communities which, being transmitted orally, is in danger of becoming lost. Moreover, it is our intention to stimulate more extensive studies on the rich medicinal flora of the country, which can provide economic and social benefits, especially to the people who traditionally cultivate or collect the plants.

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“…Using liraglutide in an animal model of spontaneously diabetic tori fatty rats, it was concluded that liraglutide protected the kidney and activated autophagy in early DKD via the AMPK/eNOS pathway independent of reductions in blood glucose and blood pressure ( Yamada et al, 2021 ). Caffeic acid, ethyl acetate or Huang-Gui Solid Dispersion (HGSD) was used in a model of Wistar rats with established DM, and it was ultimately concluded that all three drugs could activate autophagy through AMPK-mediated pathways, switching on of key downstream genes ( Matboli et al, 2017 ; Zhang et al, 2020 ; Ezzat et al, 2021 ). Purinergic receptors P2Y2R knockout impaired autophagy via the AKT/SIRT-1/FOXO3a signaling pathway in an experiment using unilateral nephrectomy combined with high fat diet and STZ ( Dusabimana et al, 2020 ).…”

Section: Dkd and Autophagymentioning

confidence: 99%

The critical role of dysregulated autophagy in the progression of diabetic kidney disease

et al. 2022

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Diabetic kidney disease (DKD) is one of the major public health problems in society today. It is a renal complication caused by diabetes mellitus with predominantly microangiopathy and is a major cause of end-stage renal disease (ESRD). Autophagy is a metabolic pathway for the intracellular degradation of cytoplasmic products and damaged organelles and plays a vital role in maintaining homeostasis and function of the renal cells. The dysregulation of autophagy in the hyperglycaemic state of diabetes mellitus can lead to the progression of DKD, and the activation or restoration of autophagy through drugs is beneficial to the recovery of renal function. This review summarizes the physiological process of autophagy, illustrates the close link between DKD and autophagy, and discusses the effects of drugs on autophagy and the signaling pathways involved from the perspective of podocytes, renal tubular epithelial cells, and mesangial cells, in the hope that this will be useful for clinical treatment.

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Phenolics from Physalis peruviana fruits ameliorate streptozotocin-induced diabetes and diabetic nephropathy in rats via induction of autophagy and apoptosis regression

Cited by 26 publications

References 78 publications

Production of a Yogurt Drink Enriched with Golden Berry (Physalispubescens L.) Juice and Its Therapeutic Effect on Hepatitis in Rats

Production of a Yogurt Drink Enriched with Golden Berry (Physalispubescens L.) Juice and Its Therapeutic Effect on Hepatitis in Rats

Poorly Investigated Ecuadorian Medicinal Plants

The critical role of dysregulated autophagy in the progression of diabetic kidney disease

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