Phenolic Profiling and Therapeutic Potential of Certain Isolated Compounds from Parkia roxburghii against AChE Activity as well as GABA_A α5, GSK-3β, and p38α MAP-Kinase Genes

Abstract

Parkia roxburghii belongs to the family Mimosaceae; it has been used since ancient times as a cure for different health complications; such as inflammatory and gynecological diseases and hemiplegia. In this investigation, a reversed-phase-high-performance liquid chromatography (RP-HPLC) profile was carried out for P. roxburghii; also, the isolated bioactive compounds including quercetin, catechin, and biochaninA were individually and/or in combination investigated for their inhibitory effects on scopolamine-induced memory impairments in mice, implying that they have the ability to reduce the neurodegenerative effects of scopolamine and thus could be employed as a more effective therapeutic agent in the treatment of Alzheimer's disease (AD) in humans. The possible interactions of Parkia flavonoids with acetylcholinesterase (AChE), γ-aminobutyric acid A receptor, alpha5 (GABA A α5), glycogen synthase kinase-3 (GSK-3), p38 mitogen-activated protein kinase (p38MAP-kinase), signal-regulated kinase (ERK), and protein-serine/threonine kinase (Akt) were then determined using molecular docking.

GANE can Improve Lung Fibrosis by Reducing Inflammation via Promoting p38MAPK/TGF-β1/NF-κB Signaling Pathway Downregulation

“…As a continuation of our interesting research in evaluation of therapeutic potential drugs of medical importance, − we report herein, a facile route to prepare a new nano-formula for gallic acid and evaluate its preventive efficacy against LPS-induced lung fibrosis in rats.…”

Morin: a promising nutraceutical therapy for modulation of the NF-kB/NOX-2/IL-6/HO-1 signaling pathways in paracetamol-induced liver toxicity

“…In the scientific literature, many hepatoprotective biologically active compounds exist, including natural and synthetic compounds 8- 12 . Several antioxidant-rich alternatives decrease the liver injury caused by paracetamol in animal models 13 . A variety of plant extracts containing saponins, polyphenols, and flavonoids have been utilized to treat a wide range of disorders 10- 13 .…”

“…Several antioxidant-rich alternatives decrease the liver injury caused by paracetamol in animal models 13 . A variety of plant extracts containing saponins, polyphenols, and flavonoids have been utilized to treat a wide range of disorders 10- 13 . Nutraceuticals and herbal medications are important owing to their low toxicity, availability, and less side effects compared with synthetic drugs 4-7,10- 13 .…”

“…A variety of plant extracts containing saponins, polyphenols, and flavonoids have been utilized to treat a wide range of disorders 10- 13 . Nutraceuticals and herbal medications are important owing to their low toxicity, availability, and less side effects compared with synthetic drugs 4-7,10- 13 . Morin is a flavanol that has been isolated from a variety of plants 14, 15 .…”

“…The pharmacological properties of morin are mediated by modulation of various cellular cytokine signaling pathways [27][28][29][30][31] . Many reports have proven the biological importance of natural products, including morin, in medicine and pharmaceutical applications 10- 13 . In this study, we evaluated the pharmaceutical impact of morin on paracetamol-induced liver toxicity in rats.…”