Phenolic profiling and evaluation of in vitro antioxidant, α-glucosidase and α-amylase inhibitory activities of Lepisanthes fruticosa (Roxb) Leenh fruit extracts

Salahuddin, Mirfat Ahmad Hasan; Ismail, Amin; Kassim, Nur Kartinee; Hamid, Muhajir; Ali, Mohd Shukuri Mohamad

doi:10.1016/j.foodchem.2020.127240

Cited by 40 publications

(42 citation statements)

References 32 publications

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“…32 Previous study describes the roots of L. fruticose are used as poultice to relieve itching and to lower the body temperature during fever. 4,33 The natives in Sarawak make use of the decoction from the roots to rehabilitate rheumatism, backache and infertility. 34 2.…”

Section: Traditional Usesmentioning

confidence: 99%

“…Mangiferin L. fruticosa (s) 33 6-gingerol L. fruticosa (s) 33 Ellagic acid L. fruticosa (s) 33 Mangiferdiol L. alata (f) 48 3-Isopentadienyl-3',4,5'-trihydroxystilbene L. alata (f) 48 Verbasoside L. alata (f) 48 Primulaverin L. alata (f) 48 Astringin L. alata (f) 48…”

Section: Other Compoundsmentioning

confidence: 99%

“…L. fruticosa (s) 33 Procyanidin B3 L. fruticosa (s) 33 Arecatannin A1 L. fruticosa (s) 33 Arecatannin A2 L. fruticosa (s) 33 1,2,6-tri-O-galloyl-β-D-glucopyranoside L. fruticosa (s) 33 Methyl 4-O-galactopyranosyl-2,3-di-O-methyl-galactopyranoside L. alata (f) 48 Benzyl alcohol-hexosidepentoside I, II L. alata (f) 48 Primeveroside L. alata (f) 48 Jasminoside R L. alata (f) 48 Pinellic acid L. alata (f) 48 2,6-dimethoxy-…”

Section: Procyanidin B2mentioning

confidence: 99%

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Phytochemistry and Pharmacological Activities of Lepisanthes Genus: A Review

2021

TJNPR

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The genus Lepisanthes belonging to Sapindaceae family, comprises of 26 species and 2 subspecies of trees and shrubs. 1 They are widely distributed in tropical region from Africa to Madagascar, South to Southeast Asia and from northwestern Australia to New Guinea. The distribution of plants according to species are summarized in Table 1. The trees of Lepisanthes genus are commonly found in a coastal forest or on islands, or in the transition zone between mangrove and dry land. It can also grow in lowland forest, wastelands, by streams, or in secondary forest up to 500 m altitude. Plants from the genus Lepisanthes are discriminated based on their micro-morphological characters such as cuticular striation, stomata structure, type of waxes, trichome 2 as well as vessels, parenchyma, rays and fiber morphology. 3 Traditionally, plants from this genus are used to cure headache, fever, 4 chest pain and nosebleed. 5 Aside from medicinal uses, it is also utilized as food preservatives and as sleep-inducing food. 6 The timbers are used for house building, manufactured as tool handles, crafted as kitchen utensil and chopped as firewood. 7 Unripe fruits are green in color and when the fruits are ripe, the color change from yellow to orange to red. Some species are planted for their fruits. [8][9][10] Due to its colorful fruits, Lepisanthes alata is used as decorative plant among local in Malaysia. 11 The fruits are 3 to 4 cm long obovoid berries borne in clusters, and can be eaten fresh, as it is sweet when ripe. This species is widely planted due to the sweetness of the fruits. The phytochemical screening of this genus has shown the presence of alkaloids, flavonoids, tannins, saponin triterpenoids, phenolics and glycosides. 6,[12][13] Pharmacological studies of the extracts showed the presence of anticancer, antimicrobial, antiacetylcholinesterase,

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Section: Traditional Usesmentioning

confidence: 99%

Section: Other Compoundsmentioning

confidence: 99%

Section: Procyanidin B2mentioning

confidence: 99%

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Phytochemistry and Pharmacological Activities of Lepisanthes Genus: A Review

2021

TJNPR

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“…The free radical scavenging assay measures the ability of antioxidants to donate hydrogen atom (electron transfer) to the stable free radical of DPPH. The reduction of the free radical to nonradical form of DPPH-H will decolorize the DPPH solution from blue to pale yellow colour [13]. Fig.…”

Section: Free Radical Assay (22-diphenyl-1picrylhydrazyl)mentioning

confidence: 99%

Antioxidants Capacity, Phenolic and Oxalate Content from Two Varieties of Solanum melongena at Different Maturity Stages

Amom¹,

Aisyah²,

Razali³

et al. 2021

AJACR

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Aims: To investigate the antioxidant activities, total phenolic and oxalate contents in two varieties of eggplant (Solanum melongena) (terung telunjuk (TT) and terung rapuh (TR)) at different maturity stages. Study design: Each sample was extracted three times (n=3) for the antioxidant activities, total phenolic and oxalates content. All the data were analysed by using ANOVA and Tukey Pairwise tests. Place and duration of study: Malaysian Agricultural Research and Development Institute (MARDI), between December 2019 and October 2020. Methodology: Two varieties of eggplant (TT and TR) were cultivated and the samples were tagged and the fruits were harvested according to their maturity stages (stage 1 – stage 4). Samples were freeze dried and extracted to evaluate the antioxidant activities as well as the total phenolic and oxalate contents. Results: Total phenolic contents (TPC) in TR were lower from stage 1 to stage 3 but high at over mature stage (stage 4) meanwhile TPC in TT increased upon maturity. The DPPH assay from the fruit extracts of TT in all maturity stages showed a stronger antioxidant activity as compared to TR, in which fruit of TT from stage 3 was double in antioxidant activity as compared to TR. The FRAP assay of both eggplants showed extracts of TT having a higher ferric reduction power in all stages as compared to TR. Meanwhile, both eggplant varieties showed different total, soluble and insoluble oxalate contents in all maturity indices. TT had the highest total oxalate content at stage 1 as compared to TR while the soluble oxalate content increased in TR in all maturity stages. The highest percentage of soluble oxalate content was observed in TR at stage 4 with 95.5%. Conclusion: Phytochemical findings from these eggplant varieties showed their potentials to improve livelihood and public health. More comprehensive studies on the bioactive compounds, structural elucidation and pharmacological evaluation are to be conducted to understand the possible effects of these phytochemical results.

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“…This is accomplished by inhibiting the enzymes involved in the digestion of carbohydrates such as α-amylase [ 6 , 7 ]. Therefore, inhibiting α-amylase could be an effective way to reduce starch digestibility, decrease the rate of glucose absorption, and consequently reduce postprandial hyperglycemia [ 8 , 9 , 10 ]. In addition to this, it has been well documented that oxidative stress plays a major role in the pathology of diabetes complications of both types of diabetes mellitus [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant Properties, Glucose-Diffusion Effects, α-Amylase Inhibitory Activity, and Antidiabetogenic Effects of C. Europaea Extracts in Experimental Animals

et al. 2021

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Caralluma europaea (Guss.) N.E.Br. (C. europaea), is a medicinal plant used traditionally to treat diabetes mellitus (DM) in Morocco. This study aimed to investigate the in vitro antioxidant properties, glucose diffusion effects, α-amylase inhibitory activity, and pancreatic protective effects of C. europaea in experimental alloxan-induced diabetes in mice. Total phenolic contents were determined by Folin–Ciocalteu colorimetric method, total flavonoid contents were measured by aluminum chloride colorimetric assay, and tannins contents were determined by employing the vanillin method. C. europaea ethyl acetate fraction exhibited high antioxidant potential in terms of radical scavenging (DPPH) (IC50 = 0.22 ± 0.01 mg/mL), β-carotene bleaching activity (IC50 = 1.153 ± 0.07 mg/mL), and Ferric-reducing antioxidant power. Glucose diffusion was significantly inhibited by the ethyl acetate fraction at 60,120and 180 min, while the aqueous extract did not have this inhibitory effect when compared with the control group. Potent α-amylase inhibitory activity was observed in the ethyl acetate fraction and the aqueous extract in vitro and in vivo using STZ-diabetic rats. On the other hand, the administration of the ethyl acetate fraction (60 mg/kg) significantly attenuated alloxan-induced death and hyperglycemia in treated mice. Furthermore, histopathological investigations revealed that the ethyl acetate fraction protected islets of Langerhans against alloxan-induced tissue alterations. These results suggest that C. europaea exhibited an important antihyperglycemic effect via the inhibition of glucose diffusion and pancreatic α-amylase activity. In addition, the antidiabetogenic effect of C. europaea might be attributed to their polyphenol and flavonoid compounds, which could be reacted alone, or in synergy, to scavenge the free radicals produced by the alloxan.

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Phenolic profiling and evaluation of in vitro antioxidant, α-glucosidase and α-amylase inhibitory activities of Lepisanthes fruticosa (Roxb) Leenh fruit extracts

Cited by 40 publications

References 32 publications

Phytochemistry and Pharmacological Activities of Lepisanthes Genus: A Review

Phytochemistry and Pharmacological Activities of Lepisanthes Genus: A Review

Antioxidants Capacity, Phenolic and Oxalate Content from Two Varieties of Solanum melongena at Different Maturity Stages

In Vitro Antioxidant Properties, Glucose-Diffusion Effects, α-Amylase Inhibitory Activity, and Antidiabetogenic Effects of C. Europaea Extracts in Experimental Animals

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