Phenolic Glycosides from the Leaves of Iodes cirrhosa Turcz. with Cytotoxic and Antimicrobial Effects

Abstract

In the present study, 14 phenolic glycosides, including one new neolignan glycoside, iodescirrhoside A (1), three new flavonol glycosides, iodescirrhosides B -D (2 -4), and 10 known metabolites were obtained from the methanol extract of Iodes cirrhosa leaves. Structural elucidation was performed by interpretating the 1D-and 2D-NMR, HR-ESI-MS, and CD spectra in comparison with literature data. All compounds were noncytotoxic to LU-1, HepG2, MCF-7, SK-Mel-2, and LNCaP cancer cell lines. Compound 11 significantly inhibited the growth of E. faecalis. In contrast, weak inhibition was observed for 1-9 and 14 against E. faecalis, for 1, 6-8, and 11 against S. aureus, for 6 and 13 against B. cereus, and 2, 4, and 6-9 against C. albicans.

Chaenomelin, a New Phenolic Glycoside, and Anti-Helicobacter pylori Phenolic Compounds from the Leaves of Salix chaenomeloides

“…Subsequently, we isolated compounds 1 – 13 from the active EtOAc fraction and assessed them for their antibacterial activity. While it has been reported that phenolic glycosides exhibit antimicrobial activity against bacteria like S. aureus , E. faecalis , and B. cereus [ 42 , 43 ], there is limited research on the antimicrobial activity of phenolic glycosides against H. pylori . Therefore, we conducted antimicrobial tests on the isolated compounds to explore their potential antimicrobial effects against H. pylori .…”