Phenolic glycosides from <i>Sanguisorba officinalis</i> and their anti-inflammatory effects

Chen, Jinfeng; Tan, Lu; Ju, Feng; Kuang, Qi-Xuan; Yang, Tian-Long; Deng, Fang; Gu, Yu‐Cheng; Jiang, Li-Shi; Deng, Yun; Guo, Da‐Le

doi:10.1080/14786419.2020.1849202

Cited by 11 publications

(8 citation statements)

References 17 publications

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“…Saponins have the ability to regulate rumen microbial communities and rumen metabolites. Research has found that elms have anti-inflammatory effects ( Chen et al, 2020 ). Studies have shown that valine is extensively metabolized in the rumen as a potential ketogenic and sugar-generating substance ( Menahan and Schultz, 1964 ) and promotes growth ( Gerulat and Berg, 1960 ).…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Reveals That the Rumen Transcriptome, Microbiome, and Its Metabolome Co-regulate Cold Season Adaptability of Tibetan Sheep

Liu

Sha

et al. 2022

Front. Microbiol.

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Tibetan sheep can maintain a normal life and reproduce in harsh environments under extreme cold and lack of nutrition. However, the molecular and metabolic mechanisms underlying the adaptability of Tibetan sheep during the cold season are still unclear. Hence, we conducted a comprehensive analysis of rumen epithelial morphology, epithelial transcriptomics, microbiology and metabolomics in a Tibetan sheep model. The results showed that morphological structure of rumen epithelium of Tibetan sheep in cold season had adaptive changes. Transcriptomics analysis showed that the differential genes were primarily enriched in the PPAR signaling pathway (ko03320), legionellosis (ko05134), phagosome (ko04145), arginine and proline metabolism (ko00330), and metabolism of xenobiotics by cytochrome P450 (ko00980). Unique differential metabolites were identified in cold season, such as cynaroside A, sanguisorbin B and tryptophyl-valine, which were mainly enriched in arachidonic acid metabolism, arachidonic acid metabolism and linolenic acid metabolism pathways, and had certain correlation with microorganisms. Integrated transcriptome-metabolome-microbiome analysis showed that epithelial gene-GSTM3 expression was upregulated in the metabolism of xenobiotics by the cytochrome P450 pathway during the cold season, leading to the downregulation of some harmful metabolites; TLR5 gene expression was upregulated and CD14 gene expression was downregulated in the legionellosis pathway during the cold season. This study comprehensively described the interaction mechanism between the rumen host and microbes and their metabolites in grazing Tibetan sheep during the cold season. Rumen epithelial genes, microbiota and metabolites act together in some key pathways related to cold season adaptation.

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Section: Discussionmentioning

confidence: 99%

Multi-Omics Reveals That the Rumen Transcriptome, Microbiome, and Its Metabolome Co-regulate Cold Season Adaptability of Tibetan Sheep

Liu

Sha

et al. 2022

Front. Microbiol.

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“…Saponins have the ability to regulate rumen microbial communities and rumen metabolites. Research has found that elms have anti-inflammatory effects [47]. In addition, tryptophyl-valine is unique to the cold season.…”

Section: Discussionmentioning

confidence: 99%

The Rumen Microbiome and Its Metabolome Together With the Host Transcriptome Act to Regulate the Cold Season Adaptation Mechanism of Grazing Tibetan Sheep

Liu

Sha

et al. 2021

Preprint

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BackgroundTibetan sheep are important ruminants on the Qinghai-Tibet Plateau. They can maintain a normal life and reproduce in harsh environments under extreme cold and low oxygen. However, the molecular and metabolic mechanisms underlying the adaptability of Tibetan sheep during the cold season are still unclear. Hence, we conducted a comprehensive analysis of rumen epithelial morphology, epithelial transcriptomics, microbiology and metabolomics in a Tibetan sheep model to understand the interaction between the rumen host and microbiota and their metabolites and to explore the potential regulatory mechanism of Tibetan sheep adaptability to the cold season of the plateau. ResultsMorphological analysis showed that the ruminal muscle layer thickness and nipple width of Tibetan sheep increased significantly during the cold season ( P <0.05), and the thickness of the stratum corneum, stratum granulosa and stratum spinous of the rumen epithelium increased significantly ( P <0.05). Transcriptomics analysis showed that the differential genes were primarily enriched in the PPAR signaling pathway (ko03320), legionellosis (ko05134), phagosome (ko04145), arginine and proline metabolism (ko00330), and metabolism of xenobiotics by cytochrome P450 (ko00980). Unique differential metabolites were identified in cold season, such as cynaroside A, sanguisorbin B and tryptophyl-valine, which were mainly enriched in arachidonic acid metabolism, arachidonic acid metabolism and linolenic acid metabolism pathways, and had certain correlation with microorganisms. Integrated transcriptome-metabolome-microbiome analysis showed that epithelial gene- GSTM3 expression was upregulated in the metabolism of xenobiotics by the cytochrome P450 pathway during the cold season, leading to the downregulation of some harmful metabolites; TLR5 gene expression was upregulated and CD14 gene expression was downregulated in the legionellosis pathway during the cold season. A large number of metabolites, such as glucosidic acid and vitamin A, were produced in the steroid hormone biosynthesis and retinol metabolism pathways. ConclusionThis study comprehensively described the interaction mechanism between the rumen host and microbes and their metabolites in grazing Tibetan sheep during the cold season. Under the stimulation of the cold plateau environment, the morphological structure of the rumen epithelium of Tibetan sheep undergoes adaptive changes. Rumen epithelial genes, microbiota and metabolites act together in some key pathways related to cold season adaptation.

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“…The absolute configuration of the monosaccharides was confirmed by comparing the retention time with those of L‐rhamnopyranose (t R =11.53 min), and D‐glucose (t R =14.64 min). The detailed process was described previously [10] …”

Section: Methodsmentioning

confidence: 99%

“…The detailed process was described previously. [10] (2,4,6-Trichloro-3-hydroxy-5-methoxyphenyl) methyl β-D-glucopyranoside (1) 1. 13 C-NMR data: see Table 1.…”

Section: Acid Hydrolysis and Derivatization Of 1 -3mentioning

confidence: 99%

Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale

Yan

Guo

Zhou

et al. 2021

Chemistry & Biodiversity

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Three previously undescribed chlorophenyl glycosides, (2,4,6‐trichloro‐3‐hydroxy‐5‐methoxyphenyl)methyl β‐D‐glucopyranoside (1), (2,4‐dichloro‐3,5‐dimethoxyphenyl)methyl 6‐O‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (2) and 4‐chloro‐3‐methoxy‐5‐methylphenyl 6‐O‐(6‐deoxy‐β‐L‐mannopyranosyl)‐β‐D‐glucopyranoside (3) were obtained from Lilium regale. The absolute configurations of these new finds were elucidated by comprehensive analyses of spectroscopic data combined with acid hydrolysis derivatization. (2,4‐dichloro‐3,5‐dimethoxyphenyl)methyl 6‐O‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (2) can inhibit the proliferation of lung carcinoma A549 cells with an IC50 value of 29 μΜ.

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Phenolic glycosides from Sanguisorba officinalis and their anti-inflammatory effects

Abstract: resolution mass (HRESIMS) as well as circular dichroism (CD). Compounds 1-4 exhibited anti-inflammatory properties in vitro by attenuating the production of inflammatory mediators, such as nitric oxide (NO) as well as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6).

Cited by 11 publications

References 17 publications

Multi-Omics Reveals That the Rumen Transcriptome, Microbiome, and Its Metabolome Co-regulate Cold Season Adaptability of Tibetan Sheep

Multi-Omics Reveals That the Rumen Transcriptome, Microbiome, and Its Metabolome Co-regulate Cold Season Adaptability of Tibetan Sheep

The Rumen Microbiome and Its Metabolome Together With the Host Transcriptome Act to Regulate the Cold Season Adaptation Mechanism of Grazing Tibetan Sheep

Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale

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