Phenolic glycosides and other constituents from the bark of Magnolia officinalis

Abstract

A new phenolic glycoside, syringic acid 4-O-β-D-glucopyranosyl-(1 → 5)-α-L-rhamnopyranoside (1), together with 12 known compounds consisting of eight phenolic glycosides (2-9), two phenolic acids (10 and 11), and two norsesquiterpenoids (12 and 13), was isolated from the methanol extract of the bark of Magnolia officinalis. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 1-11 were evaluated for their inhibitory activities against fructose-1,6-bisphosphatase, aldose reductase, lipase, dipeptidyl peptidase-IV, α-glucosidase, and three cancer cell lines. However, all the compounds showed weak or no activities in these tests.

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

“…Data suggest that syringic acid downregulates the expression of mRNA of AR [ 136 ]. However, the AR inhibition by syringic acid isolated from Magnolia officinalis was weaker with less than 10% of inhibition [ 137 ].…”

Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract

“…MOBE has been used in traditional Chinese medicine for decades in the treatment of a variety of conditions, owing to its alleged anti‐inflammatory and analgesic effect . Over recent years, MOBE has been introduced into personal care products, as it has ‘anti‐ageing’ and filling effects.…”

Magnolia officinalis bark extract, a recently identified contact allergen in ‘anti‐ageing’ cosmetics

“…M. officinalis bark extract is obtained from the M. officinalis tree, which is native to Chinese mountains and valleys; it belongs to the Magnoliaceae family and contains bio-active ingredients, such as magnolol, honokiol, 4-O-methylhonokiol, and obovatol, that allegedly have anti-inflammatory, antioxidant, anticancer, antidepressant and hepatoprotective effects (2)(3)(4)(5). It has been used in traditional Chinese medicine for the treatment of 'gastrointestinal problems' and 'asthmatic cough'.…”