Phenolic Glucosides from Flacourtia Indica

Abstract

A new phenolic glucoside, (rel)-2-(4',6'-dibenzoyl-β-glucopyranosyloxy)-7-(1α-hydroxy-2α-ethoxy-6α-acetyloxy-3oxocyclohex-4-enoyl)-benzyl alcohol (Flacourticin) (1) and the known, 2-(4',6'-dibenzoyl-β-glucopyranosyl)-5-hydroxy benzyl alcohol (4'-benzoylpoliothrysoside) (2) together with the new, (2E)-heptyl-3-(3,4-dihydroxyphenyl) acrylate (3), (+)-catechin (4) and sitosterol-β-D-glucoside were isolated from Flacourtia indica. Their structures were assigned on the basis of 1D, 2D-NMR and as well by analysis of the LC-ESIMS data. The isolated compounds (1-4) were evaluated for α,αdiphenyl-β-picrylhydrazyl (DPPH) radical scavenging activity, and 3 was found to be twofold less potent, with an IC 50 =12.01 μg/mL, compared to the positive control, Rutin, (IC 50 = 5.83 μg/mL).

Antimalarial compounds from the aerial parts of Flacourtia indica (Flacourtiaceae)

“…phenolic glycosides (Bhaumik et al, 1987;Amarasinghe et al, 2007;Chai et al, 2009;Madan et al, 2009a), a lignan (Satyanarayana et al, 1991;Chai et al, 2009), sterols (Satyanarayana et al, 1991;Dehmlow et al, 2000), a polysaccharide (Mosihuzzaman et al, 2003), flavonoids and condensed tannins (Ndhlala et al, 2007;Madan et al, 2009b).…”