Phenolic-enriched raspberry fruit extract (Rubus idaeus) resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet

Kshatriya, Dushyant; Giunta, Gina M.; Yuan, Bo; Zhao, Danyue; Simon, James E.; Wu, Qingli; Bello, Nicholas T.

doi:10.1016/j.nutres.2019.05.005

Cited by 24 publications

(30 citation statements)

References 44 publications

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“…LPL plays a key role in generating HDL cholesterol. Results also indicated that increase in lipolysis of TG-rich lipoproteins increased HDL cholesterol levels, thereby confirming that the relationship between the two is a precursor-product [39,40]. In our study, we observed that 5,7-dimethoxyflavone prevented the rise in serum TGs, TC, and LDL-C.…”

Section: Discussionsupporting

confidence: 85%

Antidiabetic and Hypolipidemic Effects of 5,7-Dimethoxyflavone in Streptozotocin-Induced Diabetic Rats

Xie

Zhang

2019

Med Sci Monit

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Departmental sources Background: The flavones are considered as competent antidiabetic molecules due to their strong antioxidant activities and higher in vivo stability. The present study evaluated the antidiabetic and hypolipidemic effects of 5,7-dimethoxyflavone in streptozotocin (STZ)-induced diabetic rat models. Material/Methods: The antidiabetic potential of 5,7-dimethoxyflavone was evaluated in streptozotocin-induced diabetic rats. The serum levels of triglyceride, total cholesterol, and high-density lipoprotein cholesterol were measured using the Randox assay kit. Histopathological examination was carried out by hematoxylin and eosin (HE) staining. Results: Oral administration of 5,7-dimethoxyflavone significantly reduced STZ-induced enhancement in blood sugar and glycosylated hemoglobin, as well as significant increases in C-peptide, insulin, hemoglobin, and total protein content (p<0.05). Additionally, treatment with 5,7-dimethoxyflavone resulted in a remarkable increase in non-enzymic antioxidants. Administration of 5,7-dimethoxyflavone had a hypolipidemic effect by significantly reducing levels of serum triglycerides, total cholesterol, and low-density lipoproteins. The histopathological examination of rat pancreases revealed the beneficial effect of 5,7-dimethoxyflavone and protection of b cell integrity in STZ-induced diabetic rats. Conclusions: These findings reflect the antidiabetic and hypolipidemic effects of 5,7-dimethoxyflavone, suggesting that 5,7-dimethoxyflavone may be a promising compound for use in development of new antidiabetic drugs.

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Section: Discussionsupporting

confidence: 85%

Antidiabetic and Hypolipidemic Effects of 5,7-Dimethoxyflavone in Streptozotocin-Induced Diabetic Rats

Xie

Zhang

2019

Med Sci Monit

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“…Adulteration of diet with RK has shown to prevent weight gain [ 16 , 17 ], however, the strong sensory profile of RK could have potentially affected food intake. Previous work from our lab supports the preventative actions of oral gavage administration of RK against weight gain and fat accumulation in a high-fat diet induced obesogenic environment [ 18 ]. Along with management of weight gain, RK can serve cardio protective roles.…”

Section: Introductionmentioning

confidence: 63%

“…RK is marketed in the United States and other countries as a nutraceutical for appetite control and weight loss [ 18 , 27 , 37 ]. This study sought to investigate the dose-dependent effects of RK on the meal patterns and hemodynamic alterations associated with an obesogenic diet.…”

Section: Discussionmentioning

confidence: 99%

“…RK has reported effects on weight gain due to an obesogenic diet in male mice when administered by admixture in the diet [ 16 , 17 ] or, in our previous studies, by oral gavage [ 18 ]. In these studies differences in weight gain were observed after three to five weeks of exposure to RK.…”

Section: Discussionmentioning

confidence: 99%

“…Daily data were used to calculate, meal frequency (meals/day), meal size (kcal), meal duration (min/meal), eating rate (kcal/min), and satiety ratio (Inter meal interval (min)/kcal). Mice that demonstrated food shredding were not included in the analyses [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

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Raspberry Ketone [4-(4-Hydroxyphenyl)-2-Butanone] Differentially Effects Meal Patterns and Cardiovascular Parameters in Mice

2020

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Raspberry ketone (RK; [4-(4-hydroxyphenyl)-2-butanone]) is a popular nutraceutical used for weight management and appetite control. We sought to determine the physiological benefits of RK on the meal patterns and cardiovascular changes associated with an obesogenic diet. In addition, we explored whether the physiological benefits of RK promoted anxiety-related behaviors. Male and female C57BL/6J mice were administered a daily oral gavage of RK 200 mg/kg, RK 400 mg/kg, or vehicle for 14 days. Commencing with dosing, mice were placed on a high-fat diet (45% fat) or low-fat diet (10% fat). Our results indicated that RK 200 mg/kg had a differential influence on meal patterns in males and females. In contrast, RK 400 mg/kg reduced body weight gain, open-field total distance travelled, hemodynamic measures (i.e., reduced systolic blood pressure (BP), diastolic BP and mean BP), and increased nocturnal satiety ratios in males and females. In addition, RK 400 mg/kg increased neural activation in the nucleus of the solitary tract, compared with vehicle. RK actions were not influenced by diet, nor resulted in an anxiety-like phenotype. Our findings suggest that RK has dose-differential feeding and cardiovascular actions, which needs consideration as it is used as a nutraceutical for weight control for obesity.

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Influence of Diet‐Induced Obesity on the Bioavailability and Metabolism of Raspberry Ketone (4‐(4‐Hydroxyphenyl)‐2‐Butanone) in Mice

Zhao

Yuan

Kshatriya

et al. 2020

Molecular Nutrition Food Res

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Objectives: Raspberry ketone (RK) is the primary aroma compound in red raspberries and a dietary supplement for weight loss. This work aims to 1) compare RK bioavailability in male versus female, normal-weight versus obese mice; 2) characterize RK metabolic pathways. Methods: Study 1: C57BL/6J male and female mice fed a low-fat diet (LFD; 10% fat) receive a single oral gavage dose of RK (200 mg kg −1 ). Blood, brain, and white adipose tissue (WAT) are collected over 12 h. Study 2: Male mice are fed a LFD or high-fat diet (45% fat) for 8 weeks before RK dosing. Samples collected are analyzed by UPLC-MS/MS for RK and its metabolites. Results: RK is rapidly absorbed (T max ≈ 15 min), and bioconverted into diverse metabolites in mice. Total bioavailability (AUC 0-12 h ) is slightly lower in females than males (566 vs 675 nmol mL −1 min −1 ). Total bioavailability in obese mice is almost doubled that of control mice (1197 vs 679 nmol mL −1 min −1 ), while peaking times and elimination half-lives are delayed. Higher levels of RK and major metabolites are found in WAT of the obese than normal-weight animals. Conclusions: RK is highly bioavailable, rapidly metabolized, and exhibits significantly different pharmacokinetic behaviors between obese and control mice. Lipid-rich tissues, especially WAT, can be a direct target of RK.

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Phenolic-enriched raspberry fruit extract (Rubus idaeus) resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet

Cited by 24 publications

References 44 publications

Antidiabetic and Hypolipidemic Effects of 5,7-Dimethoxyflavone in Streptozotocin-Induced Diabetic Rats

Antidiabetic and Hypolipidemic Effects of 5,7-Dimethoxyflavone in Streptozotocin-Induced Diabetic Rats

Raspberry Ketone [4-(4-Hydroxyphenyl)-2-Butanone] Differentially Effects Meal Patterns and Cardiovascular Parameters in Mice

Influence of Diet‐Induced Obesity on the Bioavailability and Metabolism of Raspberry Ketone (4‐(4‐Hydroxyphenyl)‐2‐Butanone) in Mice

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