Phenolic-enriched blueberry-leaf extract attenuates glucose homeostasis, pancreatic β-cell function, and insulin sensitivity in high-fat diet–induced diabetic mice

Li, Hua; Park, Hye-Mi; Ji, Hyeon-Seon; Han, Jisu; Sang-Kyum, Kim; Park, Ho-Yong; Jeong, Tae‐Sook

doi:10.1016/j.nutres.2019.09.005

Cited by 37 publications

(36 citation statements)

References 46 publications

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“…BB chemical composition greatly varies upon the cultivar, variety, growing location, environmental conditions, plant nutrition, ripeness stage, harvest time as well as the storage conditions, making the content of each individual component highly flexible, with impact on the corresponding antioxidant profiles [ 63 , 64 , 65 ]. Nonetheless, BB-derived phytochemicals display a panoply of health-related properties beyond their antioxidant profile able to interfere with chief physiological functions [ 66 , 67 , 68 ]. Therefore, public interest in BB as a functional food has increased over the last years [ 69 ].…”

Section: Blueberries Beneficial Outcomes In (Pre)diabetes Progression—a Multi-modal Functional Fruitmentioning

confidence: 99%

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

et al. 2021

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Prediabetes, a subclinical impairment between euglycemia and hyperglycemia, is a risk factor for the development of type 2 diabetes mellitus (T2DM) and associated micro- and macrovascular complications. Lifestyle therapy, the first-line treatment of prediabetes, includes physical exercise and dietary regimens enriched in phytochemicals with health-related properties. Blueberries (Vaccinium spp.), given their pleasant taste and great abundance in beneficial phytochemicals, have gained public interest all over the world. Along with a high antioxidant activity, this functional fruit is also well-recognized due to its hypoglycemic and insulin-sensitizing effects and has been recommended for overt T2DM management. Yet blueberries target several other pathophysiological traits, namely gut microbiota dysbiosis and hepatic dysmetabolism, that ensue when prediabetes begins and for which pharmacological interventions tend to be delayed. In this work, we revisited preclinical data from in vitro assays, animal models and human studies, aiming to disclose the potential mechanisms by which blueberries may be a fruitful source of phytochemicals able to prevent (pre)diabetes progression. Collectively, future efforts should focus on longer-term studies with standardized interventions and readouts, particularly in humans, that will hopefully bring more robust evidence and concrete guidance for blueberries’ effective use in prediabetes.

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Section: Blueberries Beneficial Outcomes In (Pre)diabetes Progression—a Multi-modal Functional Fruitmentioning

confidence: 99%

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

et al. 2021

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“…It was noteworthy that LBPs supplement decreased body weight gain in HFD‐fed mice, which indicated a potential resistance effect of LBPs against obesity. The addition of polyphenol‐rich blueberry leaf extract also significantly alleviated the weight gain of obese mice 42 …”

Section: Resultsmentioning

confidence: 97%

Lily bulbs’ polyphenols extract ameliorates oxidative stress and lipid accumulation in vitro and in vivo

et al. 2021

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BACKGROUND Polyphenols have the potential to reduce the risk of many metabolic disorders. Lily bulbs are rich in polyphenols; however, their effects on lipid metabolism remain unclear. This study aimed to explore the effects of lily bulbs’ polyphenols (LBPs) on oxidative stress and lipid metabolism. RESULTS A total of 14 polyphenolic compounds in LBPs were identified by high‐performance liquid chromatography equipped with diode‐array detection mass spectrometry. Total phenolic compound in LBPs was 53.76 ± 1.12 g kg−1 dry weight. In cellular experiments, LBPs attenuated the disruption of mitochondrial membrane potential, impeded reactive oxygen species production, alleviated oxidative stress, and reduced lipid accumulation in oleic acid induced HepG2 cells. In in vivo studies, LBPs significantly inhibited body weight gain, reduced lipid levels in serum and liver, and improved oxidative damage in a dose‐dependent manner in mice fed a high‐fat diet. Moreover, LBPs ameliorated hepatic steatosis and suppressed the expression of hepatic‐lipogenesis‐related genes (SREBP‐1c, FAS, ACC1, and SCD‐1) and promoted lipolysis genes (SRB1 and HL) and lipid oxidation genes (PPARα and CPT‐1) in mice fed a high‐fat diet. CONCLUSION It was concluded that LBPs are a potential complementary therapeutic alternative in the development of functional foods to curb obesity and obesity‐related diseases, such as metabolic syndrome. © 2021 Society of Chemical Industry

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“…In the current study, although there was no significant increase in Ins1 gene expression after RB extract treatment under normal glucose conditions, the expression of the Ins1 gene was significantly upregulated under high glucose conditions ( Figure 6 ). Similarly, an in vivo study by the author of [ 33 ] also demonstrated blueberry-leaf extract rich in chlorogenic acid and flavonol glycosides attenuates glucose homeostasis and improves pancreatic β-cell function by increasing the expression of several genes including Ins1. Polyphenols present in common spices, such as cinnamon, cloves, turmeric, and bay leaves, due to their doubly-linked procyanidin type-A polymers, have also shown an insulin-like activity in vitro [ 34 ].…”

Section: Discussionmentioning

confidence: 95%

Rice Bran Phenolic Extracts Modulate Insulin Secretion and Gene Expression Associated with β-Cell Function

et al. 2020

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Oxidative stress is known to modulate insulin secretion and initiate gene alterations resulting in impairment of β-cell function and type 2 diabetes mellitus (T2DM). Rice bran (RB) phenolic extracts contain bioactive properties that may target metabolic pathways associated with the pathogenesis of T2DM. This study aimed to examine the effect of stabilized RB phenolic extracts on the expression of genes associated with β-cell function such as glucose transporter 2 (Glut2), pancreatic and duodenal homeobox 1 (Pdx1), sirtuin 1 (Sirt1), mitochondrial transcription factor A (Tfam), and insulin 1 (Ins1) in addition to evaluating its impact on glucose-stimulated insulin secretion. It was observed that treatment with different concentrations of RB phenolic extracts (25-250 µg/mL) significantly increased the expression of Glut2, Pdx1, Sirt1, Tfam, and Ins1 genes and glucose-stimulated insulin secretion under both normal and high glucose conditions. RB phenolic extracts favourably modulated the expression of genes involved in β-cell dysfunction and insulin secretion via several mechanisms such as synergistic action of polyphenols targeting signalling molecules, decreasing free radical damage by its antioxidant activity, and stimulation of effectors or survival factors of insulin secretion.

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Phenolic-enriched blueberry-leaf extract attenuates glucose homeostasis, pancreatic β-cell function, and insulin sensitivity in high-fat diet–induced diabetic mice

Cited by 37 publications

References 46 publications

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

Lily bulbs’ polyphenols extract ameliorates oxidative stress and lipid accumulation in vitro and in vivo

Rice Bran Phenolic Extracts Modulate Insulin Secretion and Gene Expression Associated with β-Cell Function

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