Phenolic diterpene and α‐tocopherol contents in leaf extracts of 60 <i>Salvia</i> species

Abreu, Maria Elizabeth; Müller, Maren; Alegre, Leonor; Munné‐Bosch, Sergi

doi:10.1002/jsfa.3384

Cited by 53 publications

(46 citation statements)

References 23 publications

(26 reference statements)

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“…The main sage antioxidants are rosmarinic acid, carnosic acid, and α-tocopherol. While the α-tocopherol content is more or less similar in different herb species and varieties, the carnosic acid content can differ by a factor of up to twenty (Abreu et al 2008). This can be the explanation of the differences between our values and the published data.…”

Section: Determination Of Antioxidant Capacity Of Extractscontrasting

confidence: 46%

Antioxidant activity of selected phenols and herbs used in diets for medical conditions

Chrpová¹,

Kouřimská²,

Gordon³

et al. 2010

Czech J. Food Sci.

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Chrpová D., Kouřimská L., Gordon M.H., Heřmanová V., Roubíčková I., Pánek J. (2010): Antioxidant activity of selected phenols and herbs used in diets for medical conditions. Czech J. Food Sci., 28: 317-325.The antioxidant capacity of some herbs used in dietology practice was determined by the DPPH free radical method, which was calibrated with ascorbic acid. Partially hydrophilic phenolic compounds are the most active compounds in plants, and therefore water was used as the extraction agent. Besides antioxidant capacity, the content of total phenolic compounds was also measured and a strong correlation between these two variables was found. The extracts of lemon balm (melissa officinalis L.), peppermint (mentha x piperita L.), oregano (origanum vulgare L.), Greek oregano (origanum heracleoticum L.), sage (Salvia officinalis L.) and winter savory (Satureja montana L.) showed very significant activity. It was comparable with the activity of green tea in the case of oregano and peppermint. Lower activity was observed in the case of rosemary (rosmarinus officinalis L.), marjoram (majorana hortensis), hyssop (hyssopus officinalis L.), sweet basil (ocimum basilicum), and lovage (Levisticum officinale Koch.). The inhibitory activity of the herb extracts was monitored also during the autooxidation of lard. Very high antioxidant capacity was observed mainly in sage samples, but also in marjoram and Greek oregano. The extracts of peppermint, oregano, rosemary, winter savory, lemon balm and hyssop showed middle activity comparable to that of α-tocopherol. The antioxidant capacity of sweet basil and lovage was insignificant.

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Section: Determination Of Antioxidant Capacity Of Extractscontrasting

confidence: 46%

Antioxidant activity of selected phenols and herbs used in diets for medical conditions

Chrpová¹,

Kouřimská²,

Gordon³

et al. 2010

Czech J. Food Sci.

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“…The isolated compounds were identified by their NMR and MS spectral analysis as four diterpenes: rosmadial ( I ) (Nakatani & Inatani 1983), carnosol ( II ) (Abreu et al 2008), 16-hydroxycarnosol ( III ) (Luis, Lahlou, Andrés, Sood, et al 1996), sageone ( IV ) (Tada et al 1994); two flavonoids: cirsimaritin ( V ) (Wang et al 2004), salvigenin ( VI ) (Ayatollahii et al 2009); and three triterpenes: oleanolic acid ( VII ) (Pettit et al 1966; Martins et al 2013), uvaol (3β,28-dihydroxy-urs-12-ene) ( VIII ) (Lee et al 2013), ursolic acid ( IX ) (Pettit et al 1966; Silva et al 2008). …”

Section: Resultsmentioning

confidence: 99%

“…The plant is used for diaphoretic and diuretic effects (Dentali & Hoffmann 1990). Previous to our research, several compounds including flavonoids, mono-, sesqui-, di- and tri terpenes, have been already identified and/or isolated from S. apiana (Pettit et al 1966; González et al 1992; Luis, Lahlou, & Andrés 1996; Luis, Lahlou, Andrés, Sood, et al 1996; Dentali & Hoffmann 1990; Borek et al 2006; Abreu et al 2008; Takeoka et al 2010). However, this plant has not been studied for cannabinoid or opioid receptors activity.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and biological evaluation of Salvia apiana

Radhakrishnan

Hayes

Ross

2016

Natural Product Research

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Salvia apiana (white sage, Lamiaceae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections and poison oak rashes. The aqueous ethanolic extract of S. apiana showed moderate CB1 activity (58.3% displacement). Chromatographic purification of the ethanolic extract on silica gel column led to isolation of nine compounds: rosmadial (I), carnosol (II), 16-hydroxycarnosol (III), sageone (IV), cirsimaritin (V), salvigenin (VI), oleanolic acid (VII), 3β,28-dihydroxy-urs-12-ene (VIII), and ursolic acid (IX). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding.

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“…Naïve populations of N. bryanti prefer to feed on plants that largely contain low-molecular-weight PSCs (Abreu et al, 2008;Atsatt and Ingram, 1983;Stintzing and Carle, 2005) that are unlikely to inhibit digestive enzymes. However, coastal live oak (Quercus agrifolia), which is rich in phenolics and tannins, also grows within the native habitat of naïve N. bryanti (Atsatt and Ingram, 1983).…”

Section: Functional Implicationsmentioning

confidence: 99%

“…These populations vary in the types of PSCs they encounter in the wild. The naïve population feeds mainly on plants that produce lowmolecular-weight defense compounds that are unlikely to bind dietary or enzymatic proteins (Abreu et al, 2008;Atsatt and Ingram, 1983;Stintzing and Carle, 2005). Alternatively, creosote bush leaves produce a complex resin consisting of various phenolics, flavonoids and saponins (Mabry et al, 1977), chemical classes that have been shown to bind and inhibit digestive enzymes (Cheeke, 1971;Fontana Pereira et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Induced and constitutive responses of digestive enzymes to plant toxins in an herbivorous mammal

Kohl

Dearing

2011

Journal of Experimental Biology

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SUMMARYMany plants produce plant secondary compounds (PSCs) that bind and inhibit the digestive enzymes of herbivores, thus limiting digestibility for the herbivore. Herbivorous insects employ several physiological responses to overcome the anti-nutritive effects of PSCs. However, studies in vertebrates have not shown such responses, perhaps stemming from the fact that previously studied vertebrates were not herbivorous. The responses of the digestive system to dietary PSCs in populations of Bryantʼs woodrat (Neotoma bryanti) that vary in their ecological and evolutionary experience with the PSCs in creosote bush (Larrea tridentata) were compared. Individuals from naïve and experienced populations were fed diets with and without added creosote resin. Animals fed diets with creosote resin had higher activities of pancreatic amylase, as well as luminal amylase and chymotrypsin, regardless of prior experience with creosote. The experienced population showed constitutively higher activities of intestinal maltase and sucrase. Additionally, the naïve population produced an aminopeptidase-N enzyme that was less inhibited by creosote resin when feeding on the creosote resin diet, whereas the experienced population constitutively expressed this form of aminopeptidase-N. Thus, the digestive system of an herbivorous vertebrate responds significantly to dietary PSCs, which may be important for allowing herbivorous vertebrates to feed on PSC-rich diets. Supplementary material available online at

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Phenolic diterpene and α‐tocopherol contents in leaf extracts of 60 Salvia species

Cited by 53 publications

References 23 publications

Antioxidant activity of selected phenols and herbs used in diets for medical conditions

Antioxidant activity of selected phenols and herbs used in diets for medical conditions

Phytochemical and biological evaluation of Salvia apiana

Induced and constitutive responses of digestive enzymes to plant toxins in an herbivorous mammal

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