Phenolic contents and in vitro antioxidant, anti-tyrosinase, and anti-inflammatory effects of leaves and roots extracts of the halophyte Limonium delicatulum

Bakhouche, Imene; Aliat, Toufik; Boubellouta, Tahar; Gali, Lynda; Şen, Ayşe; Bellik, Yuva

doi:10.1016/j.sajb.2021.01.030

Cited by 29 publications

(21 citation statements)

References 47 publications

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“…The flower extracts from plants irrigated with 300 mM NaCl allowed for the lowest IC 50 value (873 µg/mL), while those from freshwater-irrigated plants were not active up to the concentration of 1000 µg/mL. However, other Limonium species have showed lower IC 50 values, namely, L. delicatulum methanol extracts from roots (9.87 µg/mL) and leaves (24.77 µg/mL) [ 68 ], as well as hexane and ethyl acetate fractions from L. effusum methanol extracts (148–295 µg/mL) [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

Metabolomic Profile and Biological Properties of Sea Lavender (Limonium algarvense Erben) Plants Cultivated with Aquaculture Wastewaters: Implications for Its Use in Herbal Formulations and Food Additives

Rodrigues

Castañeda-Loaiza

Monteiro

et al. 2021

Foods

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Water extracts from sea lavender (Limonium algarvense Erben) plants cultivated in greenhouse conditions and irrigated with freshwater and saline aquaculture effluents were evaluated for metabolomics by liquid chromatography-tandem high-resolution mass spectrometry (LC-HRMS/MS), and functional properties by in vitro and ex vivo methods. In vitro antioxidant methods included radical scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric-reducing antioxidant power (FRAP), and copper and iron chelating assets. Flowers’ extracts had the highest compounds’ diversity (flavonoids and its derivatives) and strongest in vitro antioxidant activity. These extracts were further tested for ex vivo antioxidant properties by oxidative haemolysis inhibition (OxHLIA), lipid peroxidation inhibition by thiobarbituric acid reactive substances (TBARS) formation, and anti-melanogenic, anti-tyrosinase, anti-inflammation, and cytotoxicity. Extract from plants irrigated with 300 mM NaCl was the most active towards TBARS (IC50 = 81 µg/mL) and tyrosinase (IC50 = 873 µg/mL). In OxHLIA, the activity was similar for fresh- and saltwater-irrigated plants (300 mM NaCl; IC50 = 136 and 140 µg/mL, respectively). Samples had no anti-inflammatory and anti-melanogenic abilities and were not toxic. Our results suggest that sea lavender cultivated under saline conditions could provide a flavonoid-rich water extract with antioxidant and anti-tyrosinase properties with potential use as a food preservative or as a functional ingredient in herbal supplements.

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Section: Resultsmentioning

confidence: 99%

Metabolomic Profile and Biological Properties of Sea Lavender (Limonium algarvense Erben) Plants Cultivated with Aquaculture Wastewaters: Implications for Its Use in Herbal Formulations and Food Additives

Rodrigues

Castañeda-Loaiza

Monteiro

et al. 2021

Foods

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“…Another study reported that polarity of the solvents used for extraction plays an important role in the concentration of phenols and flavonoids 24 – 26 . Indeed, several factors, such as the type of solvent, the extraction process, the part of the plant, temperature, and so on, might influence the yield and extraction of phenolic compounds 27 , 28 .…”

Section: Discussionmentioning

confidence: 99%

In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

Kaur

Sharma

Kumar³

et al. 2022

Sci Rep

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Abrus precatorius is a tropical medicinal plant with multiple medicinal benefits whose seeds have not yet been studied against cervical cancer. Herein, we have assessed the antioxidant and antiproliferative properties of seed extracts (ethyl acetate and 70% ethanol) prepared from Soxhlet and Maceration extraction methods against Hep2C and HeLa Cells. We observed that the APE (Sox) extract had a significantly higher total flavonoid content, APA (Mac) extract had a high total phenolic content, and APA (Sox) extract had a high total tannin content. Further, HPLC analysis of extracts revealed the presence of tannic acid and rutin. Moreover, APA (Sox) exhibited the highest free radical scavenging activity. APE (Mac) had the best antiproliferative activity against Hep2C cells, while APA (Sox) had the best antiproliferative activity against HeLa cells. In Hep2C cells, APE (Mac) extract revealed the highest SOD, catalase activity, GSH content, and the lowest MDA content, whereas APA (Mac) extract demonstrated the highest GST activity. In HeLa cells, APA (Sox) extract showed the highest SOD, GST activity, GSH content, and the least MDA content, whereas APA (Mac) extract showed the highest catalase activity. Lastly, docking results suggested maximum binding affinity of tannic acid with HER2 and GCR receptors. This study provides evidence that A. precatorius seed extracts possess promising bioactive compounds with probable anticancer and antioxidant properties against cervical cancer for restricting tumor growth.

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“…Many secondary compounds were identified in T. nilotica , such as phenols (nilocitin, ellagic acid, and gallic acid), flavonoids (kaempferol, tamarixetin, quercetin, isoquercitrin, flavone, and naringenin,), terpenoids, steroids, tannins, and cardiac glycosides [ 82 , 83 ]. On the other hand, previous phytochemical studies of the genus Limonium led to the isolation of flavonoids, alkaloids, tannins, carbonyl compounds, hydrocarbons, naphthoquinone, and amino acids [ 84 , 85 ]. Trabelsi et al [ 86 ] reported that L. monopetalum was more enriched with phenolic compounds (gallic, syringic, vanillic, p-coumaric, ferulic, and transcinnamic acids) and four flavonoids (quercetin, apigenin, amentoflavone, and flavones).…”

Section: Resultsmentioning

confidence: 99%

Proximate Composition, Bioactive Compounds, and Antioxidant Potential of Wild Halophytes Grown in Coastal Salt Marsh Habitats

et al. 2021

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Halophytes have been characterized as a potential resource for fiber, food, fodder, and bioactive compounds. Proximate composition, bioactive compounds, and antioxidant activity of five wild dominant halophytes (Arthrocnemummacrostachyum, Halocnemumstrobilaceum, Limoniastrummonopetalum, Limoniastrumpruinosum, and Tamarix nilotica) naturally growing along the Nile Delta coast were assessed. The soil supporting these halophytes was sandy to sand-silty, alkaline, with low organic carbon, and relatively high CaCO3. H. strobilaceum attained the highest moisture content, ash, crude fiber, lipids, and total soluble sugars. L. monopetalum showed the highest content of crude protein (18.00%), while T. nilotica had the highest content of total carbohydrates. The studied halophytes can be ranked according to their nutritive value as follows: H.strobilaceum > L.monopetalum > A.macrostachyum > L.pruinosum > T. nilotica. A. macrostachyum attained the highest amount of Na+, K+, Ca2+, and Mg2+. A. macrostachyum showed a high content of phenolic compounds, while H.strobilaceum was rich in tannins and saponin contents. The MeOH extract of A. macrostachyum and H. strobilaceum exhibited substantial antioxidant activity. The present results showed that the studied halophytes could be considered as candidates for forage production or used as green eco-friendly natural resources for bioactive compounds.

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Phenolic contents and in vitro antioxidant, anti-tyrosinase, and anti-inflammatory effects of leaves and roots extracts of the halophyte Limonium delicatulum

Cited by 29 publications

References 47 publications

Metabolomic Profile and Biological Properties of Sea Lavender (Limonium algarvense Erben) Plants Cultivated with Aquaculture Wastewaters: Implications for Its Use in Herbal Formulations and Food Additives

Metabolomic Profile and Biological Properties of Sea Lavender (Limonium algarvense Erben) Plants Cultivated with Aquaculture Wastewaters: Implications for Its Use in Herbal Formulations and Food Additives

In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

Proximate Composition, Bioactive Compounds, and Antioxidant Potential of Wild Halophytes Grown in Coastal Salt Marsh Habitats

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