Phenolic contents and in vitro investigation of the antioxidant, enzyme inhibitory, photoprotective, and antimicrobial effects of the organic extracts of Pelargonium graveolens growing in Morocco

Aanachi, Soukaina El; Gali, Lynda; Nacer, Salah Neghmouche; Bensouici, Chawki; Dari, Khadija; Aassila, Hinde

doi:10.1016/j.bcab.2020.101819

Cited by 35 publications

(22 citation statements)

References 55 publications

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“…Phlorotannins are known for their antioxidant and photoprotective capabilities since, due to the chromophores present in their structures, they are capable of neutralizing the harmful effects of oxidative stress after sun exposure [40,65]. In a study by El Aanachi and co-workers [66], the antioxidant and photoprotective potential of extracts enriched in phenolic compounds was evaluated, revealing their strong effect, due to their absorption capacity at wavelengths from 280 to 320 nm. On the other hand, Coba and co-workers [67] demonstrated that MAAs can be used as natural and safe compounds, presenting antioxidant and photoprotective effects, with potential against the harmful effects of UV radiation.…”

Section: Discussionmentioning

confidence: 99%

Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata

et al. 2021

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The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1–F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50 of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC50 of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications.

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Section: Discussionmentioning

confidence: 99%

Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata

et al. 2021

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“…The antioxidant effect of extracts in scavenging DPPH (2, 2-diphenyl-1-picrylhydrazyl) free radical was evaluated according to El Aanachi et al (2020). About 40µL of sample ranging at different concentrations was added to160 µL DPPH methanol solution (0.1 mM).…”

Section: Dpph Free Radical Scavenging Assaymentioning

confidence: 99%

Chemical profile, antioxidant and photoprotective activities of essential oil and crude extracts of Algerian Thymus serpyllum

Madouni

Meddah

Aicha

et al. 2021

Nova Biotechnol. Chim.

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Thymus serpyllum is an aromatic and medicinal plant widely used in Algerian folk medicine. It was collected from Mascara region North West of Algeria and studied in the aim to provide more knowledge about chemical composition, antioxidant and photo-protective activities of essential oil, ethanolic and infusion extracts. The chemical analysis of investigated T. serpyllum EO was performed for the first time in this research work. It was carried out by GC/MS for identifying 25 components where the dominated compounds were Carvacrol (66%) and γ–Terpinene (11.5%). The phenolic profile of ethanolic and aqueous infusion extracts was performed using HPLC chromatography and the data showed the Benzoic acid and Rosmarinc acid were found as major compounds. Extracts showed an excellent source of total phenols and flavonoids. Antioxidant activity was evaluated using DPPH, Galvinoxyl radical (GOR), CUPRAC, reducing power and O-phenanthroline approaches. All extracts showed a significant antioxidant capacity with different mechanisms. However, ethanol and infusion extracts showed stronger capacity than EO. Moreover, the photoprotective activity of T. serpyllum extracts was explored for the first time in our study. Extracts exhibited high values of sun protective factors (SFP) with 38.34±2.29 and 38.82±2.23 for ethanol and infusion extract respectively. Results of our study may encourage the pharmacologic, food and cosmetic sectors to use the wild thyme as natural and healthy source of active compounds.

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“…FRAP assay of Clinopodium nepeta extracts were evaluated using the method of reducing power described previously [ 72 ]. A total of 40 µL of phosphate buffer (pH = 6.6; 0.2 M) was added to 10 µL of sample solution (extract or standard) in methanol, with various concentrations, followed by the addition of 50 µL of potassium ferricyanide (1%).…”

Section: Methodsmentioning

confidence: 99%

Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of Clinopodium nepeta L. Kuntze

Hatem

Boudiba

Benahmed

et al. 2021

Plants

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Phenolic extracts of Clinopodium nepeta were prepared and their preliminary phenolic profiles determined using HPLC-DAD with 26 phenolic standards. Apigenin (21.75 ± 0.41 µg/g), myricetin (72.58 ± 0.57 µg/g), and rosmarinic acid (88.51 ± 0.55 µg/g) were the most abundant compounds in DCM (dichloromethane), AcOEt (ethyl acetate), and BuOH (butanol) extracts, respectively. The DCM and AcOEt extracts inhibited quorum-sensing mediated violacein production by C. violaceum CV12472. Anti-quorum-sensing zones on C. violaceum CV026 at MIC (minimal inhibitory concentration) were 10.3 ± 0.8 mm for DCM extract and 12.0 ± 0.5 mm for AcOEt extract. Extracts showed concentration-dependent inhibition of swarming motility on flagellated P. aeruginosa PA01 and at the highest test concentration of 100 μg/mL, AcOEt (35.42 ± 1.00%) extract displayed the best activity. FRAP assay indicated that the BuOH extract (A0.50 = 17.42 ± 0.25 µg/mL) was more active than standard α-tocopherol (A0.50 = 34.93 ± 2.38 µg/mL). BuOH extract was more active than other extracts except in the ABTS●+, where the DCM extract was most active. This antioxidant activity could be attributed to the phenolic compounds detected. C. nepeta extracts showed moderate inhibition on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, and α-amylase. The results indicate that C. nepeta is a potent source of natural antioxidants that could be used in managing microbial resistance and Alzheimer′s disease.

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Phenolic contents and in vitro investigation of the antioxidant, enzyme inhibitory, photoprotective, and antimicrobial effects of the organic extracts of Pelargonium graveolens growing in Morocco

Cited by 35 publications

References 55 publications

Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata

Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata

Chemical profile, antioxidant and photoprotective activities of essential oil and crude extracts of Algerian Thymus serpyllum

Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of Clinopodium nepeta L. Kuntze

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