Phenolic content of Sicilian virgin olive oils and their effect on MG-63 human osteoblastic cell proliferation

García-Martínez, Olga; Mazzaglia, Giampiero; Sánchez‐Ortíz, Araceli; Ocaña‐Peinado, Francisco M.; Rivas, Ana

doi:10.3989/gya.0111141

Cited by 13 publications

(3 citation statements)

References 32 publications

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“…The present results are in agreement with the known variable phenolic content depending on both the cultivar and geographic origin [18]. Biophenols indeed are secondary plant metabolites that act as a defense against ultraviolet radiation, and injury due to oxidation and pathogens, that in response to a very stressing environment or parasitic plant infection (insects, mold, or bacterial) can lead olive trees to increase in the biosynthesis of phenols up to 20 times.…”

Section: Resultssupporting

confidence: 90%

Quick assessment of the economic value of olive mill waste water

Delisi

Saiano²,

Pagliaro

et al. 2016

Chemistry Central Journal

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BackgroundOlive biophenols are emerging as a valued class of natural products finding practical application in the food, pharmaceutical, beverage, cosmetic and nutraceutical industries due to their powerful biological activity which includes antioxidant and antimicrobial properties. Olive mill waste water (OMWW), a by-product in olive oil manufacturing, is rich in biophenols such as hydroxytyrosol and tyrosol. The amount of biophenols depends on the cultivar, the geographical area of cultivation, and the seasonal conditions. The goal of this study was to develop a straightforward method to assess the economic value of OMWW via quantification of hydroxytyrosol and tyrosol.ResultsThe amount of hydroxytyrosol and tyrosol phenolic compounds in the OMWW from four different cultivars grown in four different regions of Sicily was analyzed using liquid–liquid and solid–liquid analytical protocols developed ad hoc. Results showed significant differences amongst the different cultivars and their geographical origin. In all samples, the concentration of hydroxytyrosol was generally from 2 to 10 times higher than that of tyrosol. In general, the liquid–liquid extraction protocol gave higher amounts of extracted biophenols. The cultivar Cerasuola had the highest amount of both hydroxytyrosol and tyrosol. The cultivar Nocellara Etnea had the lowest content of both biophenols.ConclusionsA quick method to assess the economic value of olive mill waste water via quantification of hydroxytyrosol and tyrosol in olive phenolic enriched extracts is now available.

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Section: Resultssupporting

confidence: 90%

Quick assessment of the economic value of olive mill waste water

Delisi

Saiano²,

Pagliaro

et al. 2016

Chemistry Central Journal

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“…The phenolic extract of different olive oils can enhance the proliferation of the human MG-63 osteosarcoma cell line. However, this effect was independent of the OO phenolic content [ 224 ]. Differently, MG-63 cells treated with distinct hydroxytyrosol, p-coumaric acid, caffeic acid, luteolin, ferulic acid, and apigenin enhanced OB proliferation.…”

Section: Functional Foods With Impact On Healthmentioning

confidence: 99%

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

Faienza,

Giardinelli,

Annicchiarico

et al. 2024

IJMS

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Bone health is the result of a tightly regulated balance between bone modeling and bone remodeling, and alterations of these processes have been observed in several diseases both in adult and pediatric populations. The imbalance in bone remodeling can ultimately lead to osteoporosis, which is most often associated with aging, but contributing factors can already act during the developmental age, when over a third of bone mass is accumulated. The maintenance of an adequate bone mass is influenced by genetic and environmental factors, such as physical activity and diet, and particularly by an adequate intake of calcium and vitamin D. In addition, it has been claimed that the integration of specific nutraceuticals such as resveratrol, anthocyanins, isoflavones, lycopene, curcumin, lutein, and β-carotene and the intake of bioactive compounds from the diet such as honey, tea, dried plums, blueberry, and olive oil can be efficient strategies for bone loss prevention. Nutraceuticals and functional foods are largely used to provide medical or health benefits, but there is an urge to determine which products have adequate clinical evidence and a strong safety profile. The aim of this review is to explore the scientific and clinical evidence of the positive role of nutraceuticals and functional food in bone health, focusing both on molecular mechanisms and on real-world studies.

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“…The effect of the phenolic extract on osteoblast cell growth using the human MG-63 osteosarcoma cell line was also being part of this study. The result showed that there were variations in the phenolic content produced by olive oil according to the type of cultivar and grove altitude as well as an effect on human osteosarcoma cell proliferation (García-Martínez et al, 2014). (Romeu et al, 2016) also evaluated the protective effect against oxidative DNA damage and antioxidant endogenous enzymatic system (AEES) of virgin olive oil (VOO) enriched with phenolic compounds and/or thyme phenolic compounds.…”

Section: Vegetable Oils As An Alternative Solventmentioning

confidence: 99%

Extraction of cannabinoids using vegetable oils and its uva-photoprotective effect on human skin keratinocytes

Zen

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Nowadays, vegetable oil has attracted attention in its role as an alternative solvent. Its ability to dissolve various active compounds from plants has been proven by several previous studies. Moreover, other benefits of the use of vegetable oil as a solvent are affordable, non-toxic, and eco-friendly. The extraction process is one of the crucial factors that affect the quality of cannabis. Ethanol is still consistently the best solvent for cannabis extraction in terms of yield production compared to other organic solvents used in this study including oil whose yield cannot be calculated since vegetable oil cannot be evaporated. HPTLC fingerprint revealed that the cannabis oil extracts using various vegetable oils including virgin coconut oil (VCO), olive oil (OO), perilla seed oil (PSO), sacha inchi oil (SIO), rice bran oil (RBO), and sesame seed oil (SSO) showed a similar cannabinoid profile with the organic solvent extracts which were indicated by the presence of CBG, CBN, THC, and CBD. The influence of the heating process before extraction was tested. It was found that both acid and neutral forms of cannabinoids were detected even the cannabis flowers were heated before extraction. This indicated that the heating process before extraction was not sufficiently efficient to complete the decarboxylation reaction. Extraction of the cannabis obtained from ONCB Thailand by a group of evaporable solvents tends to yield higher CBD content than THC. On contrary, the supercritical CO2 solvent yielded a higher content of THC than CBD and the highest content of both THC and CBD among other solvents tested. The vegetable oils provided the lowest amount of both CBD (0.01-0.02%w/w) and THC (0.02-0.03%w/w). For antioxidation assay, CBG, CBN, THC, CBD, and other unidentified compounds showed the activity. Within a group of organic solvents and a group of vegetable oils, the winterized supercritical CO2�(W-ScCO2) extract and the RBO extract showed the strongest activity with an IC50�value of 0.03 ? 0.006 mg/mL and 3.35 ? 0.120 mg/mL, respectively. Furthermore, the ethanol extract, the W-ScCO2 extract, and the VCO extract were tested for their UVA photoprotective effect on HaCat cells. It was found the W-ScCO2�extract significantly protected the UVA-irradiated cell whilst the VCO extract as well as pure CBD and THC showed an insignificant effect.

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Phenolic content of Sicilian virgin olive oils and their effect on MG-63 human osteoblastic cell proliferation

Cited by 13 publications

References 32 publications

Quick assessment of the economic value of olive mill waste water

Quick assessment of the economic value of olive mill waste water

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

Extraction of cannabinoids using vegetable oils and its uva-photoprotective effect on human skin keratinocytes

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