Phenolic constituents of phellodendron amurense bark

Ida, Yoshiteru; Satoh, Yohko; Ohtsuka, Masumi; Nagasao, Miki; Shoji, Jun

doi:10.1016/s0031-9422(00)90536-3

Cited by 93 publications

(73 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1). Through comparison of published NMR and EI-MS data, the structures of the known compounds were identified as cycloartenol (1), 35,36) p-hydroxybenzoic acid (2), 37) vanilloloside (3), 38) and 5Ј-O-methyladenosine (4). 39) This is the first report of isolation of these four, known compounds 1-4 from this plant.…”

Section: Resultsmentioning

confidence: 99%

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

Jung

Hyun

et al. 2010

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Nelumbo nucifera GAERTN., the family of Nelumbonaceae, is a perennial, rhizomatous, aquatic plant distributed throughout Asia, including India, China, and Egypt. The plant is comprised of: membranous, peltate, orbicular, and concave leaves; nut-contained and ovoid fruits; black, hard, and ovoid seeds; nodal roots. In Korea, China and India, various parts of N. nucifera have been used in foodstuffs and traditional medicine for the treatment of diarrhea, gastritis, insomnia, nervous prostration and as a haemostatic.1-3) In particular, numerous biological activities, including antioxidant, 4,5) anti-human immunodeficiency virus (HIV), 6) antihyperlipidemic, 1) hepatoprotective, and antiobesity effects [7][8][9] have been reported from the leaves of N. nucifera. In addition, Mukherjee et al. reported 24) Recently, N. nucifera semen extract was reported to improve memory in rats with scopolamine-induced dementia through the induction of choline acetyltransferase expression and inhibition of acetylcholinesterase (AChE).25) Even though individual parts of this plant have been the target of distinct biological and pharmacological research, there are limited studies of the stamens, with the exception of research focusing upon the antioxidant and rat lens aldose reductase (RLAR) inhibition [26][27][28] and anti-allergic activities 29) attributed to the flavonoids. Alzheimer's disease (AD) is a neurodegenerative disease and the most frequent and predominant cause of dementia in the elderly, provoking progressive cognitive decline, psychobehavior disturbances, memory loss, the presence of senile plaques, neurofibrillary tangles, and a decrease in cholinergic transmission. 30,31) Although the pathogenesis of AD is complicated and involved in numerous pathways, two major hypotheses are currently under consideration regarding the molecular mechanism, the cholinergic hypothesis and the amyloid cascade hypothesis. Thus, the focus herein is upon inhibitors of select cholinesterases (ChEs) to alleviate cholinergic deficits and improve neurotransmission and b-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1; aspartyl protease, b-secretase, and memapsin2) inhibitors to preclude formation and accumulation of amyloid b peptide (Ab). Pursuant to this, both could then be established as viable therapeutic targets for AD. [31][32][33][34] Given that numerous promising pharmaceuticals and nutraceuticals are constantly isolated from effective natural products, and that a previous study from this lab indicated potent antioxidant and RLAR inhibitory activities of N. nucifera stamens, this plant was chosen for ongoing investigations into anti-AD activities. The present work deals with the isolation and characterization of a new b-cyclogeraniol diglycoside (5), and four known compounds: cycloartenol (1); p-hydroxybenzoic acid (2); vanilloloside (3); 5Ј-Omethyladenosine (4). Furthermore, the inhibitory activities of 1-5 toward ChEs, including AChE and butyrylcholinesterase (BChE), and BACE1 were evaluated. Busanjin-gu, Busan 61...

show abstract

Section: Resultsmentioning

confidence: 99%

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

Jung

Hyun

et al. 2010

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…The fraction eluted with 60% MeOH was repeatedly subjected to column chromatography using silica gel, and octadecylsilyl silica gel, then by HPLC±ODS to a ord ten compounds (1±10). Eight were known compounds; (+)-lyoniresinol 3a-O-b-glucopyranoside (1), (-)-lyoniresinol 3a-O-b-glucopyranoside (2) (Achenbach et al, 1992), alangilignoside C (5) (Yuasa et al, 1997) (Ida et al, 1994), (+)-syringaresinol-O-b-glucopyranoside (7) (Kobayashi et al, 1985), verbascoside (8) (Miyase et al, 1982), b-hydroxyacteoside (9) (Kitakawa et al, 1984) and plucheoside B (10) (Uchiyama et al, 1989) by physical data and spectroscopic evidence.…”

Section: Resultsmentioning

confidence: 99%

Lignan glucosides from Acanthus ilicifolius

et al. 2001

View full text Add to dashboard Cite

“…HPLC to afford 27 compounds. Twenty two were identified as known compounds; plucheoside B (1), alangionoside C (2) (Otsuka et al, 1995), premnaionoside (4) (Sudo et al, 2000), (2R)-2-O-b-d-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one (HBOA-Glc, 8) (Tietze et al, 1991), (2R)-2-O-b-d-glucopyranosyl-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA-Glc, 9) (Hartenstein and Sicker, 1994) (Ono et al, 1999) (Okamura et al, 1981), adenosine (13) (Otsuka et al, 1989), verbascoside (14), isoverbascoside (15), leucosceptoside A (16) (Miyase et al, 1982), martynoside (17) (Sasaki et al, 1978), b-hydroxyacteoside (18) (Kitakawa et al, 1984), vecenin-2 (19), schaftoside (20) (Markham and Chari, 1982) (Hase et al, 1995) (Achenbach et al, 1992) (Ida et al, 1994), magnolenin C (26) (Rao and Wu, 1978), and ( (Kinjo et al, 1991) by comparison of physical data with literature values and from spectroscopic evidence.…”

Section: Resultsmentioning

confidence: 99%