Phenolic constituents of 17 Hypericum species from Turkey

Šmelcerović, Andrija; Zuehlke, Sebastian; Spiteller, Michael; Raabe, Nils; Özen, Tevfik

doi:10.1016/j.bse.2007.09.002

Cited by 49 publications

(34 citation statements)

References 14 publications

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“…Hyperforin was detected only at flowering in both species as reported by Smelcerovic et al (2008). On the other hand, the same authors also reported low amounts of hypericin and pseudohypericin (0.02 and 0.04 mg/g DW, respectively) in H. orientale whereas we did not detect the corresponding compounds in this species.…”

Section: Discussionsupporting

confidence: 61%

“…On the other hand, the same authors also reported low amounts of hypericin and pseudohypericin (0.02 and 0.04 mg/g DW, respectively) in H. orientale whereas we did not detect the corresponding compounds in this species. Hypericum plants were collected in northeastern part of Anatolia and ontogenetic stages were not established by Smelcerovic et al (2008). In our case, wild plant samples were harvested in the Black Sea region of Anatolia separated from sampling sites of Smelcerovic et al (2008) by 350 km distance.…”

Section: Discussionmentioning

confidence: 99%

“…Hypericum plants were collected in northeastern part of Anatolia and ontogenetic stages were not established by Smelcerovic et al (2008). In our case, wild plant samples were harvested in the Black Sea region of Anatolia separated from sampling sites of Smelcerovic et al (2008) by 350 km distance. Therefore, the different sampling procedures and great differences in habitats among the previous and present studies may be reason for the absence of hypericins in H. orientale.…”

Section: Discussionmentioning

confidence: 99%

“…depilatum var. depilatum and H. orientale were reported to contain hypericin, pseudohypericin, hyperforin and several flavonoids (Smelcerovic et al, 2008). It was also reported that total hypericin content significantly changed during the course of plant development in H. aviculariifolium subp.…”

Section: Research Articlementioning

confidence: 97%

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Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Çırak

Radušienė

Camas

et al. 2013

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Research Articlementioning

confidence: 97%

See 2 more Smart Citations

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Çırak

Radušienė

Camas

et al. 2013

Pharmaceutical Biology

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“…Continuing our research on the chemical composition (6)(7)(8)(9)(10)(11) and pharmacological activities (11)(12)(13)(14) of Hypericum species, in the present study extracts of Table 1 contains data on the identity of nine assayed Hypericum species, their taxonomic placement within sections of the genus Hypericum, voucher numbers of the deposited herbarium specimens (Herbarium Moesicum Doljevac, Serbia), collection period and locality (15). Collection was done in the blooming stage.…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites of Hypericum L. Species as Xanthine Oxidase Inhibitors

Šmelcerović¹,

Smelcerovic²,

Tomovic³

et al. 2017

Acta Facultatis Medicae Naissensis

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SU M M A RYNine Hypericum species (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum and H. umbellatum) collected in Serbia were assayed for inhibitory potential against xanthine oxidase in vitro, on the commercial enzyme, and compared with allopurinol. Seven studied Hypericum species (H. barbatum, H. rochelii, H. rumeliacum, H. umbellatum, H. perforatum, H. tetrapterum and H. olympicum) inhibit commercial xanthine oxidase with an IC50 below 100 µg/mL. H. barbatum exerted the most potent inhibitory effect (IC50 = 31.84 ± 6.64 µg/mL), followed closely by H. perforatum (IC50 = 37.12 ± 4.06 µg/mL). Key words: xanthine oxidase inhibition, Hypericum, secondary metabolites O r i g i n a l a r t i c l e 276Acta facultatis medicae Naissensis 2017; 34(3): 275-281 I NT ROD U CT I ONXanthine oxidase (XO) is a validated target for therapeutic treatment of gout, hyperuricemia and associated conditions, with a few XO inhibitors present on the market (1). Levels of XO in plasma are enhanced also in ischemia-reperfusion injury, hemorrhagic shock, cholecystis, hypercholesterolemia, adult respiratory distress syndrome, carcinogenesis, which provides additional indications where XO inhibitors may exert their therapeutic potential (2).Secondary metabolites from plants have a long tradition of being used as therapeutics in medicine (3). Hypericum species are traditionally used as medicinal plants all over the world (4). H. perforatum (St. John's wort) is one of the best chemically determined species. The investigation of Hypericum species have increased over the years due to evidenced bioactivities of compounds found in H. perforatum. Chemically, naphthodianthrones, primarily hypericin and pseudohypericin, phloroglucinol derivatives, especially hyperforin, and flavonoids quercetin, quercitrin, hyperoside and rutin represent the main constituents in the Hypericum species (5).Continuing our research on the chemical composition (6-11) and pharmacological activities (11)(12)(13)(14) of Hypericum species, in the present study extracts of nine Hypericum species (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum and H. umbellatum), collected in Serbia, were evaluated for inhibitory potential against XO in vitro, on the commercial enzyme. Table 1 contains data on the identity of nine assayed Hypericum species, their taxonomic placement within sections of the genus Hypericum, voucher numbers of the deposited herbarium specimens (Herbarium Moesicum Doljevac, Serbia), collection period and locality (15). Collection was done in the blooming stage. MATERIALS AND METHODS Plant material Preparation of plant extractsThe extractions were performed using 3 g dry plant material and 30 mL of ethanol, using an indirect sonication method. Sonications lasted 30 min, using a Bandelin Sonorex Digital 10 P apparatus (Bandelin). At the end of extraction, filtration was done in order to separate the extracts from the residual plan...

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Cellular‐Specific Detection of Polyphenolic Compounds by NMR‐and MS‐Based Techniques

Hölscher

2019

Recent Advances in Polyphenol Research

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Phenolic constituents of 17 Hypericum species from Turkey

Cited by 49 publications

References 14 publications

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Secondary Metabolites of Hypericum L. Species as Xanthine Oxidase Inhibitors

Cellular‐Specific Detection of Polyphenolic Compounds by NMR‐and MS‐Based Techniques

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