Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways

Cao, Mingyuan; Wang, Jie; Jiang, Xueying; Sun, Zhipeng; Zhao, Liyan; Chen, Guitang

doi:10.1021/acs.jafc.3c05900

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…It has been previously reported that increased free fatty acid levels result in the saturation of intracellular lipids predominantly diacylglycerol (DAG) and ceramide, disrupting insulin-Akt signaling and reducing glucose utilization [ 47 ]. A few previous studies have demonstrated that natural compound extracts, such as those from Caulerpa lentillifera and Black Quinoa, alleviate insulin resistance through the PI3K/Akt pathway in diabetic mice and HepG2 cells, respectively [ 48 , 49 ]. Hence, supporting our hypothesis, QG may serve as a drug to alleviate insulin resistance through the activation of insulin-Akt signaling.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Anti-Diabetic Potential of Quercetagitrin through Dual Inhibition of PTPN6 and PTPN9

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Nam

et al. 2024

Nutrients

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Protein tyrosine phosphatases (PTPs) are pivotal contributors to the development of type 2 diabetes (T2DM). Hence, directing interventions towards PTPs emerges as a valuable therapeutic approach for managing type 2 diabetes. In particular, PTPN6 and PTPN9 are targets for anti-diabetic effects. Through high-throughput drug screening, quercetagitrin (QG) was recognized as a dual-target inhibitor of PTPN6 and PTPN9. We observed that QG suppressed the catalytic activity of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM) in vitro and enhanced glucose uptake by mature C2C12 myoblasts. Additionally, QG increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and insulin-dependent phosphorylation of Akt in mature C2C12 myoblasts. It further promoted the phosphorylation of Akt in the presence of palmitic acid, suggesting the attenuation of insulin resistance. In summary, our results indicate QG’s role as a potent inhibitor targeting both PTPN6 and PTPN9, showcasing its potential as a promising treatment avenue for T2DM.

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Section: Discussionmentioning

confidence: 99%