Phenolic compounds profile of water and ethanol extracts of Euphorbia hirta L. leaves showing antioxidant and antifungal properties

Mekam, Pascal Noel; Martini, Serena; Julienne, Nguefack; Tagliazucchi, Davide; Stefani, Emilio

doi:10.1016/j.sajb.2019.11.001

Cited by 55 publications

(28 citation statements)

References 61 publications

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“…Separation was performed with a C18 column (HxSil C18 Reversed phaseHamilton, 250 × 4.6 mm, 5 μm particle size, Hamilton Company, Reno, NV, USA) by using a binary gradient of water/formic acid and acetonitrile. The mobile phase composition, the flow rate, the elution gradient, the negative and positive ESI-MS parameters as well as the quantification method are fully described in Martini et al [ 24 , 29 ] and Mekam et al [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Influence of Cooking Methods on Onion Phenolic Compounds Bioaccessibility

Cattivelli

Conte

Martini

et al. 2021

Foods

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The impact of domestic cooking (baking, boiling, frying and grilling) and in vitro digestion on the stability and release of phenolic compounds from yellow-skinned (YSO) and red-skinned onions (RSO) have been evaluated. The mass spectrometry identification pointed out flavonols as the most representative phenolic class, led by quercetin-derivatives. RSO contained almost the double amount of phenolic compounds respect to YSO (50.12 and 27.42 mg/100 g, respectively). Baking, grilling and primarily frying resulted in an increased amount of total phenolic compounds, especially quercetin-derivatives, in both the onion varieties. Some treatments promoted the degradation of quercetin-3-O-hexoside-4′-O-hexoside, the main compound present in both the onion varieties, leading to the occurrence of quercetin-4′-O-hexoside and protocatechuic acid-4-O-hexoside. After in vitro digestion, the bioaccessibility index for total phenolic compounds ranged between 42.6% and 65.5% in grilled and baked YSO, respectively, and between 39.8% and 80.2% in boiled and baked RSO, respectively. Baking contributed to the highest amount of bioaccessible phenolic compounds for both the onion varieties after in vitro digestion. An in-depth design of the cooking process may be of paramount importance in modulating the gastro-intestinal release of onion phenolic compounds.

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Section: Methodsmentioning

confidence: 99%

Influence of Cooking Methods on Onion Phenolic Compounds Bioaccessibility

Cattivelli

Conte

Martini

et al. 2021

Foods

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“…The chemical structures of all E. hirta phytochemicals and the control samples (positive and negative) used in molecular docking can be found in the Supplementary Materials. In total, 298 phytochemical Benzenoids/benzene and substituted derivatives 1-(3-aminophenyl)ethanol (Rautela et al,2020) C 8 H 11 NO −4.6 1 -O-butyl 2-O-tetradecyl benzene-1,2-dicarboxylate (Ogunlesi et al,2009) C 26 H 42 O 4 −4.9 benzoic acid (Ali et al,2020) C 7 H 6 O 2 −4.5 benzamide, 3-fluoro-N-butyl-N-ethyl (Rautela et al,2020) C 13 H 18 FNO −4.9 gallic acid (Bach et al,2020;Linfang et al, 2012;Mahomoodally et al,2020;Mekam et al,2019, Suganthi andRavi, 2018;Wu et al,2012) C 7 H 6 O 5 −5.5 ethyl gallate (Mekam et al,2019) C 9 H 10 O 5 −5.7 methyl gallate (Mahomoodally et al,2020) C 8 H 8 O 5 −5.6 protocatechuic acid (Mahomoodally et al,2020) C 7 H 6 O 4 −5.4 1-(3-ethoxyphenyl)propan-2-one (Rautela et al,2020) C 11 H 14 O 2 −5.0 methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate (Perumal and Mahmud, 2013) C 18 H 28 O 3 −6.5 Benzenoid/naphthalene [6-(4-cyanophenyl)naphthalen-2-yl] hexanoate (Rautela et al,2020) C 23 H 21 NO 2 −6.5 Benzenoids/phenols benzene-1,2,3-triol (Karki et al,2019) C 6 H 6 O 3 −4.9 2-tert-butyl-4-methoxyphenol (Rautela et al,2020) C 11 H 16 O 2 −5.1 4-ethenyl-2-methoxyphenol (Rautela et al,2020) C 9 H 10 O 2 −4.7 Benzenoid 1,2-benzenedicarboxylic acid diisooctyl ester (Ogunlesi et al,2009) C 24 H 38 O 4 −5.4 Hydrocarbon/saturated hydrocarbon Tetradecane (Ogunlesi et al,2009) C 14 H 30 −4.2 Hydrocarbon/unsaturated hydrocarbon (E)-pentatriacont-17-ene (Rautela et al,2020) C 35 H 70 −4.4 Lignans, neolignans, and related compounds/aryltetralin lignans Isolintetralin (Zhang et al,2020) C 23 H 28 O 6 −7.1 Lintetralin (Zhang et al,2020) C 23 H 28 O 6 −7.3 Phyltetralin (Zhang et al,2020) C 24 H 32 O 6 −7.0 Hypophyllanthin (Zhang et al,2020) C 24 H 30 O 7 −6.9 Lignans, neolignans, and related compounds/dibenzylbutane lignans Niranthin (Zhang et al,2020) C 24 H 32 O 7 −6.3 5-demethox...…”

Section: Phytochemical Mining and Classificationmentioning

confidence: 99%

Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease

Cayona

Creencia

2022

Front. Mol. Biosci.

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Euphorbia hirta L. is a medicinal plant widely used in the Philippines and across tropical Asia against various diseases, including respiratory disorders. In this study, the phytochemical components of E. hirta were investigated in silico for their potential to inhibit the severe acute respiratory syndrome-coronavirus-2 main protease (SARS-CoV-2 Mpro), a coronavirus disease 2019 (COVID-19) drug target that plays a critical role in the infection process of SARS-CoV-2. Phytochemical mining in tandem with virtual screening (PM-VS) was the strategy implemented in this study, which allows efficient preliminary in silico assessment of the COVID-19 therapeutic potential of the reported phytochemicals from the plant. The main rationale for considering E. hirta in the investigation was its reported efficacy against respiratory disorders. It is very promising to investigate the phytochemicals of E. hirta for their potential efficacy against diseases, such as COVID-19, that also target the respiratory system. A total of 298 E. hirta phytochemicals were comprehensively collected from the scientific literature. One hundred seventy of these phytochemicals were computed through molecular docking and were shown to have comparable or better binding properties (promising inhibitors) toward SARS-CoV-2 Mpro than known in vitro inhibitors. In connection to our previous work considering different medicinal plants, antiviral compounds were also rediscovered from the phytochemical composition of E. hirta. This finding provides additional basis for the potential of the plant (or its phytochemicals) as a COVID-19 therapeutic directly targeting drug targets such as SARS-CoV-2 Mpro and/or addressing respiratory-system-related symptoms. The study also highlights the utility of PM-VS, which can be efficiently implemented in the preliminary steps of drug discovery and development.

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“…Two phenolic acids were identified only in leaf extracts. Thus, peak 19 gave a molecular formula C 27 H 24 O 18 and revealed an MS/MS fragment at 169 allowing its identification as trigalloyl‐glucose which was previously identified in Malpighiales order [13] . Peak 48 was identified as pyrogallol A since it showed a molecular formula C 12 H 12 O 6 and it was previously found in Phyllanthaceae family [14] .…”

Section: Resultsmentioning

confidence: 82%

A Prospective of Multiple Biopharmaceutical Activities of Procyanidins‐Rich Uapaca togoensis Pax Extracts: HPLC‐ESI‐TOF‐MS Coupled with Bioinformatics Analysis

Sinan

Aktümsek

Cádiz-Gurrea

et al. 2021

Chemistry & Biodiversity

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The article reports the chemical composition, antioxidant, six key enzymes inhibitory and antimicrobial activities of two solvent extracts (water and methanol) of leaves and stem bark of Uapaca togoensis. For chemical composition, methanol extract of stem bark exhibited significant higher total phenolic (129.86 mg GAE/g) and flavanol (10.44 mg CE/g) contents. Methanol extract of leaves and water extract of stem bark showed high flavonoids (20.94 mg RE/g) and phenolic acid (90.40 mg CAE/g) content, respectively. In addition, HPLC‐ESI‐TOF‐MS analysis revealed that U. togoensis was rich in procyanidins. The methanol and water extracts of stem bark had overall superior antioxidant activity; however, only methanol extract of stem bark showed higher inhibition of cholinesterase (AChE: 2.57 mg GALAE/g; BChE: 4.69 mg GALAE/g), tyrosinase (69.53 mg KAE/g) and elastase (2.73 mmol CE/g). Potent metal chelating ability was showed by water extract of leaves (18.94 mg EDTAE/g), higher inhibition of amylase was detected for water extracts of leaves (0.94 mmol ACAE/g) and stem bark (0.92 mmol ACAE/g). The tested extracts have shown wide‐spectrum antibacterial properties and these effects have shown to be more effective against Aspergillus ochraceus, Penicillium funiculosum, Trichoderma viride, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The results revealed that the antioxidant, enzyme inhibitory and antimicrobial activities depended on the extraction solvents and the parts of plant. Bioinformatics analysis on the 17 major compounds showed modulation of pathway associated with cancer. In brief, U. togoensis might be valuable as potential source of natural agents for therapeutic application.

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Phenolic compounds profile of water and ethanol extracts of Euphorbia hirta L. leaves showing antioxidant and antifungal properties

Cited by 55 publications

References 61 publications

Influence of Cooking Methods on Onion Phenolic Compounds Bioaccessibility

Influence of Cooking Methods on Onion Phenolic Compounds Bioaccessibility

Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease

A Prospective of Multiple Biopharmaceutical Activities of Procyanidins‐Rich Uapaca togoensis Pax Extracts: HPLC‐ESI‐TOF‐MS Coupled with Bioinformatics Analysis

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