Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B

Zhang, Juan; Shen, Qiang; Lu, Jincai; Li, Jingya; Liu, Wenyong; Yang, Jian-Jun; Li, Jia; Xiao, Kai

doi:10.1016/j.foodchem.2009.09.031

Cited by 79 publications

(44 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absolute configuration of 303 was determined by X-ray analysis. This compound showed inhibition of PTP1B with an IC 50 value of 2.11±0.66 μmol/L [35] . Research on an extract of the Okinawan sponge Plakortis (unknown species) led to the isolation of manzamenones B 304 and E 305, which are fatty acid derivatives possessing a bicycle [4,3,0]nonane skeketon [217] .…”

Section: Wwwchinapharcom Jiang Cs Et Almentioning

confidence: 95%

“…Quercetin-3-O-β-D-glucuronide 15 and myricetin-3-O-β-Dglucuronide 16 were isolated from the leaves of C paliurus [35] . Compound 16 (IC 50 =9.47±3.31 μg/mL) was slightly less active than 15 (IC 50 =7.39±1.15 μg/mL), indicating that the decrease in activity is attributed to the addition of one hydroxyl group to C-5' in ring B.…”

Section: Flavonoidsmentioning

confidence: 99%

“…Isolated from the aerial parts of Artemisia minor, phenolic acid 136 was found to be a PTP1B inhibitor with an IC 50 value of 3.06 μmol/L [77] . Together with 136, another three phenolic acids 137 [35] , 138 and 139 [78] were isolated from the leaves of the plant Cyclocarya paliurus and the fruiting body of the fungus Phellinus linteus, respectively. [79] .…”

Section: Phenolic Acidsmentioning

confidence: 99%

“…Compound 193 was prepared by condensing dimethyl malonate with vanillin in the presence of B 2 O 3 and (BuO) 3 B to prevent Knoevenagel condensation [119,120] . 4-Di-O-β-D-glucopyranoside 194, isolated from the leaves of the plant Cyclocarya paliurus, showed inhibitory activity against PTP1B with an IC 50 value of 10.50±2.67 µmol/L [35] . Physcion 195, isolated from the ethanol extract of the plant Ardisia japonica, showed weak inhibitory activity [121] .…”

Section: Miscellaneousmentioning

confidence: 99%

See 3 more Smart Citations

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

2012

View full text Add to dashboard Cite

This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.

show abstract

Section: Wwwchinapharcom Jiang Cs Et Almentioning

confidence: 95%

Section: Flavonoidsmentioning

confidence: 99%

Section: Phenolic Acidsmentioning

confidence: 99%

Section: Miscellaneousmentioning

confidence: 99%

See 2 more Smart Citations

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

2012

View full text Add to dashboard Cite

show abstract

“…It was demonstrated that berberineome, papaverine and flavonoid are all effective anti-diabetic herb through inhibite PTP1B [48,49] and significantly reduce the fasting blood glucose levels [50]. Flavonoid isolated from Glycyrrhiza inflata, Cyclocarya paliurus and Pongamia pinnata can also inhibiter PTP1B activity [51,52]. Terpenoids as organic compounds distribute in plants, animals and marine life.…”

Section: Ptp1b Inhibitors and Therapy Of Type 2 Diabetesmentioning

confidence: 99%

Type 2 Diabetes Mellitus and Protein-Tyrosine Phosphatase 1B1

Zou¹

2016

JDMDC

View full text Add to dashboard Cite

Diabetes is one of the common metabolic diseases, mainly divided into two types, type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin resistance is the main performance of type 2 diabetes mellitus which are relative to some gene mutation, genetics, obesity and so on. Protein-tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator in insulin signaling pathways that are implicated in metabolic diseases such as obesity and type 2 diabetes. Many evidences from clinical and basical reseach shows that the high expression of PTP1B induces insulin resistance and PTP1B is an effective target for the treatment of type 2 diabetes mellitus. In this review, we briefly introduce composition of PTP1B, and then examine the role of PTP1B in insulin signaling of type 2 diabets mellitus. Finally, we highlight the recent research progress of PTP1B inhibitors used in therapy of type 2 diabetes mellitus. medications such as oxidation, nitrosyaltion, sulfyhydration, sumoylation, phosphorylation and proteolytic cleavage. The diverse modifications illustrated the dynamic regulation of this enzyme and its ability to modulate numerous signaling pathways likely in a cell/tissue-and stimulus-dependent manner, with high specificity and precision. PTP1B, as a potential target for type2 diabetes and obesity, have expanded out of PTP1B gene cDNA span [11]. At the same time, the molecular dynamics studies of interaction between PTP1B and its inhibitors are also going on [12], all which lay a foundation for screening specific PTP1B inhibitors. Keywords: The role of PTP1B in insulin signaling of type 2 diabetes mellitusThe pathogenesis of type 2 diabetes are associated with gene mutation, heredity, obesity and other factors, which main performance is insulin resistance. Dysfunction of pancreatic β cells is one of basic processes and characteristic of the pathogenesis. The increased prevalence of this disease highlights the urgent need to elucidate the underlying molecular mechanisms to aid in therapeutic intervention. Insulin secreted from pancreatic β cells acts as a major regulator of glucose homeostasis through a complex and integrated signaling network. Insulin receptor is a kind of transmembrane glycoprotein complex molecules, consisting of two alpha and beta subunits by three disulfide bond connection, among which the alpha subunits locate in the lateral of the cell and beta subunits are across the cell membrane. Insulin binding alpha subunits of the receptor induced phosphorylation of tyrosine residues and protein tyrosine kinase (PTK) of beta subunits, and resulted in a series of phosphorylation and dephosphorylation cascade reactions including mitogen-activated protein kinases (MAPK) and PI3K/Akt signal pathways to regulate metabolism. Whereas, when the concentration of insulin is beyond the physiological concentration (hyperinsulinemia), insulin promoted cell proliferation and developments, which may due to the combination of insulin with insulin-like growth factor 1 receptor (IGF-1R) or insulin-...

show abstract

Modulation of leptin resistance by food compounds

Aragonès

Ardid-Ruiz

Ibars

et al. 2016

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Leptin is mainly secreted by white adipose tissue and regulates energy homeostasis by inhibiting food intake and stimulating energy expenditure through its action in neuronal circuits in the brain, particularly in the hypothalamus. However, hyperleptinemia coexists with the loss of responsiveness to leptin in common obese conditions. This phenomenon has been defined as leptin resistance and the restoration of leptin sensitivity is considered to be a useful strategy to treat obesity. This review summarizes the existing literature on potentially valuable nutrients and food components to reverse leptin resistance. Notably, several food compounds, such as teasaponins, resveratrol, celastrol, caffeine, and taurine among others, are able to restore the leptin signaling in neurons by overexpressing anorexigenic peptides (proopiomelanocortin) and/or repressing orexigenic peptides (neuropeptide Y/agouti-related peptide), thus decreasing food intake. Additionally, some nutrients, such as vitamins A and D, can improve leptin transport through the blood-brain barrier. Therefore, food components can improve leptin resistance by acting at different levels of the leptin pathway; moreover, some compounds are able to target more than one feature of leptin resistance. However, systematic studies are necessary to define the actual effectiveness of each compound.

show abstract

Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B

Cited by 79 publications

References 28 publications

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Type 2 Diabetes Mellitus and Protein-Tyrosine Phosphatase 1B1

Modulation of leptin resistance by food compounds

Contact Info

Product

Resources

About